Development of an UPLC-QTOF-MS method for qualitative and quantitative analysis of Saussurea eopygmaea

• Autorzy: Liao Z. X. , Zhang B. B. , Ding L. S. , Zhou Y.
• Języki publikacji: EN

Abstrakty

EN

An ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry UPLC-QTOF-MS method has been developed for qualitative and quantitative analysis major compounds in Saussurea eopygmaea Hand-Mazz, which has long been used as a traditional Tibetan medicine. This method was validated to be sensitive, precise, and accurate with the limits of detection of compounds 2,3,4,6, and 7 with 0.67–1.90 μg mL ^-1, the overall intra-day and inter-day variations less than 8.45%, and the overall recovery over 93.8%, respectively. The correlation coefficients (R2) of the calibration curves were higher than 0.998. In addition, by comparison MS and MS/MS spectra with those of authentic compounds and literatures, a total of 14 main peaks were identified within 6 min. These results demonstrate that this approach has the potential for quality control of S. eopygmaea and other Tibetan herbal medicines.

Słowa kluczowe

EN

UPLC; QTOF-MS; Saussurea eopygmaea

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2013
• Tom: Vol. 25, no. 1
• Strony: 171--180
• Opis fizyczny: Bibliogr. 36 poz., rys., tab.

Twórcy

autor

Liao Z. X.

• Southeast University Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering Nanjing 211189 China
• Southeast University Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research Nanjing 211189 China

autor

Zhang B. B.

• Southeast University Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering Nanjing 211189 China

autor

Ding L. S.

• Chinese Academy of Sciences Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology Chengdu 610041 China

autor

Zhou Y.

• Chinese Academy of Sciences Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology Chengdu 610041 China

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