A simple HPLC method containing greener modifier and slighter temperature elevated for simultaneous determination of three statin drugs in tablets

• Autorzy: Alshitari Wael , Al-Shehri Fatimah , Abd El-Hady Deia , Albishri Hassan M.

Identyfikatory

DOI

10.1556/1326.2021.00896

• Języki publikacji: EN

Abstrakty

EN

Statins drugs are thought to be among the most prescribed drugs worldwide for the treatment of hypercholesterolaemia. A simple and reliable RP-HPLC method has been successfully employed for simultaneously separating and qualifying three statin drugs including atorvastatin, rosuvastatin and simvastatin in pharmaceutical tablets. The optimal conditions were mobile phase 50:50 (v/v) (formic acid pH 2.50: ETOH), column temperature 40.00 °C, detection wavelength 238.00 nm, and flow rate 1.00 mL/min. The proposed method has been validated based on the ICH guidelines in terms of linearity, precision, accuracy, and limit of detection and limit of quantification. The linear range investigated 2.0–80.0, 4.0–100.00, and 12.00–120.00 µg/mL for rosuvastatin, atorvastatin and simvastatin respectively with coefficients of determination (R2) within the range of 0.9993–0.9995. The LOD and LOQ for rosuvastatin, atorvastatin and simvastatin were (1.57, 4.76 µg/mL), (1.87, 5.66 µg/mL), (3.46, 10.49 µg/mL) respectively. In addition, in order to evaluate the feasibility of the method developed, it was employed towards the quantification of the pharmaceutical tablets for the analytes investigated and excellent recovery was obtained.

Słowa kluczowe

EN

statins drugs; RP-HPLC; tablets

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2022
• Tom: Vol. 34, no. 2
• Strony: 210--215
• Opis fizyczny: Bibliogr. 18 poz., rys., tab.

Twórcy

autor

Alshitari Wael

• Department of Chemistry, College of Science, University of Jeddah, P.O. 80327, 21589, Jeddah, Saudi Arabia

autor

Al-Shehri Fatimah

• Chemistry Department, Faculty of Science, King Abdulaziz University, 80203 Jeddah, Saudi Arabia
• Jammom Pharmaceutical Company, P.O. 6267, 21442, Jeddah, Saudi Arabia

autor

Abd El-Hady Deia

• Department of Chemistry, College of Science, University of Jeddah, P.O. 80327, 21589, Jeddah, Saudi Arabia

autor

Albishri Hassan M.

• Chemistry Department, Faculty of Science, King Abdulaziz University, 80203 Jeddah, Saudi Arabia

Bibliografia

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Uwagi

Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023).