Determination of ligustrazine in rat serum by polymer monolithic micro-extraction combined with ultra high performance liquid chromatography-tandem mass spectrometry

• Autorzy: Sun Danling , Peng Xitian , Peng Maomin , Zhang Xian , Xia Hong , Xu Zhimin , Hu Xizhou

Identyfikatory

DOI

10.1556/1326.2020.00811

• Języki publikacji: EN

Abstrakty

EN

This study focused on developing an effective and environmentally friendly method to measure ligustrazine in rat serum by using polymer monolith micro-extraction (PMME) technique. A poly (methacrylic acid-ethylene glycol dimethacrylate) material was used to extract ligustrazine through hydrophobic and ion-exchange interaction. Qualitative and quantitative analysis was performed by a liquid chromatography and tandem mass spectrometry. After optimization of several PMME conditions, the developed method exhibited excellent extraction performance to the ligustrazine. Good linearity was acquired ranging from 10 to 2,000 ng mL⁻¹, and the limit of detection of the proposed method was 0.14 ng mL⁻¹. The recoveries measured by spiking three different concentrations in rat serum ranged from 82.6 to 95.3%, and excellent precision was found with relative standard deviations (RSDs) less than 8.3% for intra-day and 9.7% for inter-day, respectively. At last, the applicability of the method was further confirmed through continuous monitoring of ligustrazine in rat serum after dosing of ligustrazine tablets to rats.

Słowa kluczowe

EN

polymer monolith microextraction; PMME; determination; ligustrazine; rat serum

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2021
• Tom: Vol. 33, no. 3
• Strony: 253--260
• Opis fizyczny: Bibliogr. 27 poz., rys., tab.

Twórcy

autor

Sun Danling

• College of Laboratory Medicine, Hubei University of Chinese Medicine, Wuhan, 430065, China

autor

Peng Xitian

• Institute of Quality Standards and Testing Technology for Agro-Products, Hubei Academy of Agricultural Sciences/Hubei Key Laboratory of Nutritional Quality and Safety of Agro-products, Wuhan, 430064, China

autor

Peng Maomin

• Institute of Quality Standards and Testing Technology for Agro-Products, Hubei Academy of Agricultural Sciences/Hubei Key Laboratory of Nutritional Quality and Safety of Agro-products, Wuhan, 430064, China

autor

Zhang Xian

• Institute of Quality Standards and Testing Technology for Agro-Products, Hubei Academy of Agricultural Sciences/Hubei Key Laboratory of Nutritional Quality and Safety of Agro-products, Wuhan, 430064, China

autor

Xia Hong

• Institute of Quality Standards and Testing Technology for Agro-Products, Hubei Academy of Agricultural Sciences/Hubei Key Laboratory of Nutritional Quality and Safety of Agro-products, Wuhan, 430064, China

autor

Xu Zhimin

• School of Nutrition and Food Sciences, Louisiana State University, Baton Rouge, LA, 70803, USA

autor

Hu Xizhou

• Institute of Quality Standards and Testing Technology for Agro-Products, Hubei Academy of Agricultural Sciences/Hubei Key Laboratory of Nutritional Quality and Safety of Agro-products, Wuhan, 430064, China
• School of Nutrition and Food Sciences, Louisiana State University, Baton Rouge, LA, 70803, USA

• https://orcid.org/0000-0003-3125-1577

Bibliografia

• 1. Xiao, M.; Qian, C. Y.; Luo, X.; Yang, M. B.; Zhang, Y. F.; Wu, C. Y.; Mok, C.; Lee, P.; Zuo, Z. J. Ethnopharmacol. 2019, 235, 100–10.
• 2. Chen, Z. J.; Zhang, C.; Gao, F.; Fu, Q.; Fu, C. M.; He, Y.; Zhang, J. M. Food Chem.Toxicol. 2018, 119, 309–25.
• 3. Lei, X. Q.; Li, G.; Cheng, L.; Wang, X. L.; Meng, F. Y. J. Pharm. Biomed. Anal. 2018, 154, 123–37.
• 4. Zhang, L. Y.; Zhang, W.; Chen, W. L.; Chen, G.,. J. Pharm. Biomed. Anal. 2016, 131, 107–12.
• 5. He, Y. F.; Li, Q.; Bi, K. S. J. Sep.Sci. 2015, 38 (7), 1090–9.
• 6. Wang, H.; Bao, Q.; Yi, H.; Xia, Q. J. Ethnopharmacol. 2019, 239, 111895.
• 7. Wang, Q.; Sun, H.; Yu, L.; Ma, X.; Jiang, B.; Bi, C.; Wang, Z.; Fan, Q.; Yu, Y.; Liu, Y.; Nie, H. Naunyn Schmiedeberg’s Arch. Pharmacol. 2019, 392 (5), 565–72.
• 8. Li, S. Q.; Yi, X. T.; Li, L. F.; Wu, H. N. World J. Biochem. Mol. Biol. 2018, 3 (1), 16–21.
• 9. Liu, J. L.; Zheng, S. L.; Fan, Q. J.; Yuan, J. C.; Yang, S. M.; Kong, F. L., Asian J. Chem. 2014, 26 (16), 5026–8.
• 10. Li, L. L.; Zhang, Z. R.; Gong, T.; He, L. L.; Deng, L. J. Pharm. Biomed. Anal. 2006, 41 (4), 1083–7.
• 11. Lv, K.; Li, H.; Ding, M. J. Chromatogr. A 2000, 878 (1), 147–52. 12. Li, Y.; Li, Y. F.; Wang, L.; Zou, L. N.; Ye, B. X. Anal. Method 2016, 8 (10), 2144–9.
• 13. Yan, S.; Yue, Y. Z.; Yang, L. L.; Bian, Y. Y.; Yue, J.; Zeng, L. Int. J. Electrochem. Sci. 2017, 12 (9), 8495–503.
• 14. Li, H. L.; Wang, B. J.; Yuan, G. Y.; Guo, R. C. Int. J. Clin. Pharmacol. Ther. 2018, 56 (8), 387–92.
• 15. Liao, W. G.; Huang, X. J.; Yin, Y. X.; Liu, B.; Zhu, R. Z. Biomed. Chromatogr. 2018, 32 (6), 11.
• 16. Zeng, M. F.; Zhang, J.; Yang, Y. F.; Jin, Y.; Xiao, W.; Wang, Z. Z.; Ding, G.; Yan, R. J. J. Pharm. Biomed. Anal. 2014, 88, 354–63.
• 17. Lv, Y. F.; Hu, X.; Cheng, W. M.; Nie, Y. L.; Bi, K. S. Chromatographia 2008, 68 (1–2), 105–10.
• 18. Wang, Z. J.; Wo, S. K.; Wang, L.; Lau, C. B. S.; Lee, V. H. L.; Chow, M. S. S.; Zuo, Z. J. Pharm. Biomed. Anal. 2009, 50 (2), 232–44.
• 19. Wang, P.; Jin, X.; Qi, M.; Fang, L. J. Chromatogr. B 2004, (813), 263–8.
• 20. Fan, Y.; Feng, Y. Q.; Da, S. L.; Shi, Z. G. Anal. Chim. Acta 2004, 523 (2), 251–8.
• 21. Ali, I.; Gupta, V. K.; Aboul-Enein, H. Y.; Hussain, A. J. Sep. Sci. 2008, 31 (11), 2040–53.
• 22. Fang, W. L.; Xia, L. J.; Huang, X.; Guo, X. F.; Ding, J.; Wang, H.; Feng, Y. Q. Chromatographia 2018, 81 (10), 1381–9.
• 23. Wang, R.; Li, W. Q.; Chen, Z. L. Anal. Chim. Acta 2018, 1018, 111–8.
• 24. Zhang, J.; Chen, B. B.; Wang, H.; He, M.; Hu, B. Anal. Chem. 2017, 89 (12), 6878–85.
• 25. Hu, X. Z.; Wang, J. X.; Feng, Y. Q. J. Agric. Food Chem. 2010, 58 (1), 112–9.
• 26. Nair, A. B.; Jacob, S. J. Basic Clin. Pharm. 2016, 7 (2), 27–31.
• 27. Taylor, P. J. Clin. Biochem. 2005, 38 (4), 328–34.