Ftalan dibutylu. Dokumentacja proponowanych dopuszczalnych wielkości narażenia zawodowego

Kupczewska-Dobecka, Małgorzata; Czubacka, Ewelina

doi:10.54215/PiMOSP/4.111.2022

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Ftalan dibutylu. Dokumentacja proponowanych dopuszczalnych wielkości narażenia zawodowego

Autorzy

Kupczewska-Dobecka Małgorzata , Czubacka Ewelina

Treść / Zawartość

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malgorzata_kupczewska_dobecka_1_2022.pdf

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Identyfikatory

DOI

10.54215/PiMOSP/4.111.2022

Warianty tytułu

Dibutyl phthalate. Documentation of proposed values of occupational exposure limits (OELs)

Języki publikacji

Abstrakty

Ftalan dibutylu (DBP) jest stosowany jako dodatek zmiękczający do żywic i polimerów, a także jako środek żelujący, rozpuszczalnik, środek przeciwpieniący, przy wytwarzaniu farb nitrocelulozowych, włókien szklanych, kosmetyków, osłonek leków, insektycydów oraz jako środek smarny. W dostępnym piśmiennictwie dostępne są jedynie informacje dotyczące narażenia zawodowego na mieszaninę par i aerozoli plastyfikatorów ftalanowych. U narażonych na ftalany przy produkcji mężczyzn stwierdzono polineuropatie. Ftalan dibutylu jest zaklasyfikowany jako substancja działająca szkodliwie na rozrodczość kategorii zagrożenia 1B. Wartość LOAEL dla działania na rozrodczość manifestującego się istotnym i zależnym od dawki zwiększeniem częstości występowania morfologicznie nieprawidłowych plemników u szczurów wynosi 31 mg/kg mc./dzień. Z kolei u myszy obserwowano zmniejszenie masy jąder, opóźnienie spermatogenezy oraz zaburzenia dojrzewania komórek Sertolego w wyniku narażenia na ftalan dibutylu w dawce ≥1 mg/kg mc./dzień. Za skutek krytyczny działania ftalanu dibutylu przyjęto działanie drażniące na drogi oddechowe oraz działanie na rozrodczość. Jako podstawę wyliczenia wartości NDS przyjęto wyniki 4-tygodniowego doświadczenia na szczurach. Za wartość NOAEC dla miejscowego działania drażniącego na drogi oddechowe przyjęto stężenie 1,18 mg/m³ . Na podstawie przeprowadzonych obliczeń zaproponowano przyjąć stężenie 0,6 mg/m³ jako wartość NDS dla par i aerozoli ftalanu dibutylu. Nie ustalono wartości chwilowej, NDSCh.

Dibutyl phthalate (DBP) is used as a softening additive for resins and polymers, and as a solvent, defoamer, in the production of nitrocellulose paints, glass fibers, cosmetics, drug casings, insecticides. The available literature provides information on occupational exposure to a mixture of vapors and aerosols of phthalate plasticizers only. Polyneuropathy was found in men exposed to phthalates during production. Dibutyl phthalate is classified as toxic for reproduction category 1B. The LOAEL for reproductive effects, as manifested by a significant and dose-dependent increase in the incidence of morphologically abnormal sperm in rats, is 31 mg/kg bw/day. In turn, in mice, decreased testicular weight, delayed spermatogenesis and impaired maturation of Sertoli cells were observed as a result of exposure to dibutyl phthalate at a dose of ≥ 1 mg/kg bw/day. Irritation to the respiratory tract and effect on reproduction were considered to be a critical effect of dibutyl phthalate. The results of a 4-week experiment on rats were used as the basis for the calculation of the MAC value. The concentration of 1.18 mg/m³ was adopted as the NOAEC. It was proposed to assume the concentration of 0.6 mg/m³ as the MAC value. Short term exposure value has not been established.

Słowa kluczowe

ftalan dibutylu NDS narażenie zawodowe skutki toksyczne nauki o zdrowiu inżynieria środowiska

dibutyl phthalate OEL MAC occupational exposure toxic effects health sciences environmental engineering

Wydawca

Centralny Instytut Ochrony Pracy - Państwowy Instytut Badawczy

Czasopismo

Podstawy i Metody Oceny Środowiska Pracy

Rocznik

2022

Tom

Nr 1 (111)

Strony

81--131

Opis fizyczny

Bibliogr. 194 poz., rys., tab.

Twórcy

autor

Kupczewska-Dobecka Małgorzata

Malgorzata.Dobecka@imp.lodz.pl

Instytut Medycyny Pracy im. prof. dr. med. Jerzego Nofera 91-348 Łódź, ul. św. Teresy od Dzieciątka Jezus 8 POLAND

https://orcid.org//0000-0001-9633-9428

autor

Czubacka Ewelina

Instytut Medycyny Pracy im. prof. dr. med. Jerzego Nofera 91-348 Łódź, ul. św. Teresy od Dzieciątka Jezus 8 POLAND

https://orcid.org/0000-0002-6158-536X

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