Wykorzystanie grafenu w medycynie : studium literaturowe

Bojko, Ł.; Ryniewicz, A. M.

Artykuł - szczegóły

Tytuł artykułu

Wykorzystanie grafenu w medycynie : studium literaturowe

Autorzy

Bojko Ł. , Ryniewicz A. M.

Treść / Zawartość

Pełne teksty:

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Identyfikatory

Warianty tytułu

Use of graphene in medicine : the study of literature

Języki publikacji

Abstrakty

Wstęp i cele: Wyizolowanie warstwy grafenu przez Andre Geim i Kostya Novoselov nastąpiło w 2004 roku. Ze względu na specyficzne właściwości elektryczne, optyczne, chemiczne i mechaniczne grafen znalazł zastosowanie w wielu dziedzinach, w tym w medycynie. Opracowanie poświęcone jest podsumowaniu najnowszych osiągnięć wykorzystania grafenu w procesie dostarczania leków, wykrywania i obrazowania struktur tkankowych, komórkowych i genowych, w tym terapii nowotworów oraz jako materiał w inżynierii tkankowej. Materiał i metody: Materiałem jest literatura dotycząca zagadnień zastosowania grafenu w medycynie. Zastosowano metodę analizy merytorycznej. Wyniki: Analiza literatury pokazuje, że przeszkodami dla biomedycznych zastosowań nanomateriałów na bazie grafenu jest brak biodegradacji i możliwość wystąpienia toksyczności długoterminowej, a obecne badania nie dostarczają pełnej wiedzy w zakresie oddziaływania in vivo nanomateriałów na bazie grafenu, o różnej strukturze, wielkości i właściwości powierzchni. Wniosek: Efektywność kierowania markerów do guzów nowotworowych jest jednym z kluczowych wyzwań biomedycznych dotyczących nie tylko materiałów na bazie grafenu, ale także większości innych nanomateriałów.

Introduction and aims: The isolation of graphene layers by Andre Geim and Kostya Novoselov was in 2004. Due to the specific properties of the electrical, optical, chemical and mechanical properties, graphene has been applied in many fields, including medicine. Study is devoted to the summary of the latest achievements in the use of graphene to drug delivery, sensing and imaging tissue, cellular, and gene structures, including cancer therapy and as a material for tissue engineering. Material and methods: The material is literature on the issues of application of graphene in medicine. The method of theoretical analysis. Results: Analysis of the literature shows that obstacles to biomedical applications of nanomaterials based on graphene is the lack of biodegradability and the possibility of long-term toxicity and current research does not provide the full knowledge of the interactions in vivo graphene-based nanomaterials, with a different structure, size and surface properties. Conclusion: Efficiency of targeting cancerous tumors markers is one of the key challenges regarding not only the biomedical materials based on graphene, but also most other nanomaterials.

Słowa kluczowe

podawanie leków podawanie genów nanoplatformy terapia nowotworów skafoldy

drug delivery gene delivery nanoplatforms cancer therapy scaffolds

Wydawca

Wyższa Szkoła Techniczno-Ekonomiczna w Szczecinie

Czasopismo

Problemy Nauk Stosowanych

Rocznik

2015

Tom

T. 3

Strony

147--156

Opis fizyczny

Bibliogr. 50 poz., rys., tab., wykr.

Twórcy

autor

Bojko Ł.

Akademia Górniczo-Hutnicza, Wydział Inżynierii Mechanicznej i Robotyki, Katedra Konstrukcji i Eksploatacji Maszyn

autor

Ryniewicz A. M.

anna@ryniewicz.pl

Akademia Górniczo-Hutnicza, Wydział Inżynierii Mechanicznej i Robotyki, Katedra Konstrukcji i Eksploatacji Maszyn

Bibliografia

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3. Chen G.Y., et al.: A graphene-based platform for induced pluripotent stem cells culture and differentiation. Biomaterials, 2012, 33, Nr 2, 418-427.
4. Chen W.H., et al.: Composites of aminodex-tran-coated Fe3O4 nanoparticles and graphene oxide for cellular magnetic resonance imaging. ACS Applied Materials & Interfaces, 2011, 3, Nr 10, 4085-4091.
5. Cuong T.V., et al.: Photoluminescence and Raman studies of graphene thin films prepared by reduction of graphene oxide. Materials Letters, 2010, 64, Nr 3, 399-401.
6. Das S., et al.: Localized in situ polymerization on graphene surfaces for stabilized graphene dispersions. ACS Applied Materials & Interfaces, 2011, 3, Nr 63, 1844-1851.
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Uwagi

Opracowanie ze środków MNiSW w ramach umowy 812/P-DUN/2016 na działalność upowszechniającą naukę (zadania 2017).

Typ dokumentu

Bibliografia

Identyfikator YADDA

bwmeta1.element.baztech-a4e92eab-a1fe-401e-bdfd-13ca6e68b1ab