Isolation of quinolone alkaloids from Tetradium ruticarpum via preparative high-speed counter-current chromatography and evaluation of their binding affinities for bovine serum albumin

• Autorzy: Zou H. , Guo G. , Wang M. , Huang G.

Identyfikatory

DOI

10.1556/1326.2017.00174

• Języki publikacji: EN

Abstrakty

EN

By application of preparative high-speed counter-current chromatography (HSCCC) to the crude quinolone alkaloids (1.1 g) from the fruit of Tetradium ruticarpum, 1-methyl-2((6Z,9Z)-pentadecadienyl)-4(1H)-quinolone (1, 8.4 mg), dihydroevocarpine (2, 27.0 mg), and 1-methyl-2-pentadecyl-4(1H)-quinolone (3, 18.8 mg) were isolated in one step with sufficient purity using the solvent system composed of hexane–ethyl acetate–methanol–water (Hex–EtOAc–MeOH–H2O, 5:2:5:3). Further purification of the subfraction was performed by amending the solvent composition and achieved another three quinolone alkaloids, i.e., 1-methyl-2-undecylquinolin-4(1H)-one (4, 13.7 mg), (Z)-1-methyl-2-(tridec-5-en-1-yl) quinolin-4(1H)-one (5, 14.0 mg) from subfraction FR3-A3-85 using Hex–EtOAc–MeOH–H2O (5:3.5:8.75:8.25), and 1-methyl-2-nonylquinolin-4(1H)-one (6, 15.1 mg) from subfraction FR3-A3-36 using Hex–EtOAc–MeOH–H2O (5:3.8:5:4.8). The relationship between the structure of the six alkaloids and their affinities for bovine serum albumin (BSA) was investigated using fluorescence titration analysis. The length and the presence of double bond of the side chain affected their binding process with BSA. The binding behavior might influence their other biological activities.

Słowa kluczowe

EN

Quinolone alkaloid; HSCCC; binding affinity; fluorescence titration analysis

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2018
• Tom: Vol. 30, no. 2
• Strony: 73--80
• Opis fizyczny: Bibliogr. 29 poz., rys., tab.

Twórcy

autor

Zou H.

• College of Life and Environmental Sciences, Shanghai Normal University, Shanghai, 201418, P. R. China

autor

Guo G.

• College of Life and Environmental Sciences, Shanghai Normal University, Shanghai, 201418, P. R. China

autor

Wang M.

• College of Life and Environmental Sciences, Shanghai Normal University, Shanghai, 201418, P. R. China

autor

Huang G.

• College of Life and Environmental Sciences, Shanghai Normal University, Shanghai, 201418, P. R. China
• Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, P. R. China

Bibliografia

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Uwagi

PL

Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2018).