Optyczne metody obrazowania molekularnego

Sołtysiński, T.; Liebert, A.; Zawicki, I.; Maniewski, R.

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Tytuł artykułu

Optyczne metody obrazowania molekularnego

Autorzy

Sołtysiński T. , Liebert A. , Zawicki I. , Maniewski R.

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Warianty tytułu

Optical methods of molecular imaging

Języki publikacji

Abstrakty

Obrazowanie molekularne jest szybko rozwijającą się dziedziną badań w zakresie biotechnologii i inżynierii biomedycznej. W artykule przedstawiono przegląd technik stosowanych w obrazowaniu molekularnym, wykorzystujących metody medycyny nuklearnej oraz optyczne techniki oparte na analizie promieniowania fluorescencyjnego. W szczególności opisano metody optyczne obrazowania molekularnego stosowane w skali mikroskopowej (mikroskopia konfokalna, obrazowanie czasu relaksacji fluorescencyjnej, transfer energii Foerstera) oraz wykorzystywane w badaniach na zwierzętach doświadczalnych. Omówiono także potencjalne wykorzystanie technik optycznych w badaniach dużych objętości tkanek.

Molecular imaging (MI) is a rapidly emerging field of biomedical, biotechnological and engineering research. This study provides a brief review of the state-of-the-art techniques and methods of MI based on nuclear physics and fluorescent agents. Special attention will be focused on optical methods of MI applied in microscopic scale (multiphoton confocal microscopy, fluorescence lifetime imaging, Forster energy transfer) and in experimental animals. Potential application of MI in large tissue volumes will be also discussed.

Słowa kluczowe

metody optyczne obrazowanie molekularne

optical methods molecular imaging

Wydawca

Jacek Doskocz

Czasopismo

Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna

Rocznik

2008

Tom

Vol. 14, nr 4

Strony

331--335

Opis fizyczny

Twórcy

autor

Sołtysiński T.

tsoltysinski@ibib.waw.pl

Instytut Biocybernetyki i Inżynierii Biomedycznej, Polska Akademia Nauk, ul. Trojdena 4, 02-109 Warszawa, tel. +48 (0) 22 6599143

autor

Liebert A.

Instytut Biocybernetyki i Inżynierii Biomedycznej, Polska Akademia Nauk, ul. Trojdena 4, 02-109 Warszawa, tel. +48 (0) 22 6599143

autor

Zawicki I.

Instytut Biocybernetyki i Inżynierii Biomedycznej, Polska Akademia Nauk, ul. Trojdena 4, 02-109 Warszawa, tel. +48 (0) 22 6599143

autor

Maniewski R.

Instytut Biocybernetyki i Inżynierii Biomedycznej, Polska Akademia Nauk, ul. Trojdena 4, 02-109 Warszawa, tel. +48 (0) 22 6599143

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