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Antimicrobial and antifungal polymers are gaining the attention of pharmaceutical makers and industrial design. Nanospheres-Polymers attached Platinum(II) / (IV) complexes have been synthesized to investigate antimicrobial activities. Firstly, nanospheres involving Schiff bases were synthesized from (aminomethyl) polystyrene and four substitute salicylaldehyde (2-hydroxy benzaldehyde, 5-fluoro-2-hydroxy benzaldehyde, 5-kloro-2-hydroxy benzaldehyde, 5-bromo-2-hydroxy benzaldehyde). Secondly, polymers attached Platinum(II) / (IV) complexes have been prepared by means of template method. The IR spectra show that the ligands act in a monovalent bidentate fashion all nanospheres involving Schiff bases. Square-planar and octahedral structures are proposed for Pt(II) and Pt(IV), respectively. All these substances have been examined for antibacterial activity against pathogenic strains, and antifungal activity. In particular, Pt(IV) complexes were more potent bactericides than all of the synthesized substances.
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74--80
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Bibliogr. 22 poz., rys., tab.
Twórcy
autor
- Ahi Evran University, Faculty of Arts and Science, Department of Biology, Kırşehir, Türkiye
autor
- Kırklareli University, Faculty of Arts and Science, Department of Chemistry, Kırklareli, Turkiye
- Gazi University, Faculty of Science, Department of Chemistry, Ankara, 06500, Turkiye
autor
- Gazi University, Faculty of Science, Department of Chemistry, Ankara, 06500, Turkiye
autor
- Gazi University, Faculty of Science, Department of Chemistry, Ankara, 06500, Turkiye
autor
- Gazi University, Faculty of Science, Department of Chemistry, Ankara, 06500, Turkiye
autor
- Gazi University, Faculty of Science, Department of Chemistry, Ankara, 06500, Turkiye
autor
- Gazi University, Faculty of Science, Department of Chemistry, Ankara, 06500, Turkiye
Bibliografia
- 1. Liechty, W.B., Kryscio, D.R., Slaughter, B.V. & Peppas, N.A. (2010). Polymers for drug delivery systems. Annu. Rev. Chem. Biomol. Eng. 1, 149-173. DOI: 10.1146/annurev-chembioeng-073009-100847.
- 2. Hughes, G.A. (2005). Nanostructure-mediated drug delivery. Nanomed 1, 22-30. DOI: 10.1016/j.nano.2004.11.009.
- 3. Kohli, A.K. & Alpar, H.O. (2004). Potential use of nanoparticles for transcutaneous vaccine delivery: effect of particle size and charge. Int. J. Pharm. 275, 13-17. DOI: 10.1016/ j.ijpharm.2003.10.038.
- 4. Abel, E.W., Heard P.J., Orrell, K.G., Hursthouse, M.B. & Mazid, M.A. (1993). Halogenotrimethylplatinum (IV) complexes of 2,6-bis(p-tolylthiomethyl) pyridine (L1): nuclear magnetic resonance studies of their solution state stereodynamics and the crystal structure of fac-[PtBrMe3L1]: J. Chem. Soc. Dalton Trans. 4, 3795-3801. DOI: 10.1039/DT9930003795.
- 5. Abel, E.W., Orrell, K.G., Osborne, A.G., Pain, H.M., Sik, V., Hursthouse, M.B. & Malik, K.M.A. (1994). 2,2’:6’,2’’-Terpyridine( terpy) acting as a fluxional bidentate ligand. Part 4.cis-[m(c6f5)(2)(terpy)] (m= pd or pt)-nuclear-magnetic-resonance studies of their solutiondynamics and crystal-structure of cis-[pd(c6f5)(2)(terpy)]. J. Chem. Soc., Dalton Trans. 23, 3441-3449. DOI: 10.1039/DT9940003441.
- 6. Yam, V.W.W., Tang, R.P.L., Wong, K.M.C. & Cheung, K.K. (2001) Synthesis, luminescence, electrochemistry and ion-binding studies of platinum(II)terpyridyl acetylide complexes. Organomet. 20, 4476-4482. DOI: 10.1021/om010336x.
- 7. Yam, V.W.W., Chan, K.H.Y., Wong, K.M.C. & Zhu, N.Y. (2005). Luminescent platinum(II) terpyridyl complexes: Effect of counter ions on solvent-induced aggregation and color changes. Eur. J. Chem. 11, 4535-4543. DOI: 10.1002/chem.200500106.
- 8. Pratesi, G., Perego, P., Polizzi, D., Righetti, S.C., Supino, R., Caserini, C., Manzotti, C., Giuliana, F.C., Pezzoni, G., Spinelli, S., Farrell, N. & Zunino, F.Br. (1999). A novel charges trinuclear platinum complex effective against cisplatin-resistant tumours, hypersensitivity of p53-mutant human tumour xenografts. J. Cancer 80, 1912-1919. DOI: 10.1038/sj.bjc.6690620.
- 9. Kelland, L.R., Sharp, S.Y., O’Neill, C.F., Raynaud, F.I., Beale, P.J. & Judson, I.R. (1999). Mini-review: discovery and development of platinum complexes designed to circumvent cisplatin resistance. J. Inorg Biochem. 77, 111-115. DOI: 10.1016/ S0162-0134(99)00141-5.
- 10. Orlandi, L., Colella, G., Bearzatto, A., Abolafio, G., Manzotti, L., Daidone, M.G. & Zaffaroni, N. (2001). Effects of a novel trinuclear platinum complex in cisplatin-sensitive and cisplatin-resistant human ovarian cancer cell lines: interference with cell cycle progression and induction of apoptosis. Eur. J. Cancer. 37, 649-659. DOI: 10.1016/S0959-8049(00)00445-7.
- 11. Wheate N.J. & Collins, J.G. (2003). Multi-nuclear platinum complexes as anti-cancer drugs. Coord. Chem. Rev. 241, 133-145. DOI: 10.1016/S0010-8545(03)00050-X.
- 12. Ahmedi, T.S., Wang, Z.L., Green, T.C., Henglein, A. & El-Sayed, M.A. (1996). Shape- controlled synthesis of colloidal platinum nanoparticles. Science 272, 1924-1925. DOI: 10.1126/ science.272.5270.1924.
- 13. Algül, O., Ozçelik, B., Abbasoğlu, U. & Gümüş, F. (2005). Synthesis, characterization and genotoxicity of platinum(II) complexes with substituted. Turk. J. Chem. 29, 607-615.
- 14. Herricks, T., Chen, J.Y., Xia, Y.N. (2004). Polyol synthesis of platinum nanoparticles: control of morphology with sodium nitrate. Nano Lett. 4, 2367-2371.
- 15. Asharani, P.V., Xinyi, N., Prakash, H.M. & Valiyaveettil, S. (2010). DNA damage and p53 - mediated growth arrest in human cells treated with platinum nanoparticles. Nanomed 5, 51-64. DOI: 10.1021/nl048570a.
- 16. Sarı, N. & Yüzüak, N. (2006). Synthesis, characterization of novel polymeric schiff bases their complexes. J. Inorg. Organomet. Polym. Mater. 16, 259-264. DOI: 10.1007/s10904-006-9056-5.
- 17. Gopal, J., Hasan, N., Manikandan, M. & Wu, H.F. (2013). Bacterial toxicity/compatibility of platinum nanospheres, nanocuboids and nanoflower. Sci. Rep. 3, 1260. DOI: 10.1038/ srep01260.
- 18. Nartop, D. & Sarı, N. (2012). Novel Poly(styrene) attached Schiff Bases for uptake Mn(II) and Ni(II)ions and as antimicrobial agent against micrococcus luteus. J. Inorg. Organomet. Polym. 22, 772-779. DOI: 10.1007/s10904-011-9634-z.
- 19. Sarı, N., Pişkin, N., Öğütcü, H. & Kurnaz, N. (2013). Spectroscopic characterization of novel D-aminoacid-Schiff bases and their Cr(III) and Ni(II) complexes as antimicrobial agents. Med. Chem. Res. 22, 580-587. DOI: 10.1007/s00044-012-0039-5.
- 20. Bozkır, E., Sari, N. & Öğütçü, H. (2012). Polystyrene containing carbinolamine/azomethine potentially useful as antimicrobial agent synthesis and biological evaluation. J. Inorg. Organomet. Polym. Mater. 22, 1146-1155. DOI: 10.1007/ s10904-012-9697-5.
- 21. Swihart, D.L. & Mason, W.R. (1970). Electronic spectra of octahedral platinum (IV) complexes. Inorg. Chem. 9, 1749-1757. DOI: 10.1021/ic50089a029.
- 22. Keland, L.R., Mistry, P., Abel, G., Loh, S.Y., O’Neil, C.F., Murer, B.A. & Harrap, K.R. (1992). Mechanism-related circumvention of acquired cis- diamminedichloroplatinum (II) resistance using two pairs of human ovarian carcinoma cell lines by ammine/amine platinum(IV) dicarboxylates. Cancer Res. 52, 3857-3864.
Uwagi
Opracowanie ze środków MNiSW w ramach umowy 812/P-DUN/2016 na działalność upowszechniającą naukę (zadania 2017).
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-a3034b49-d7b9-4f5a-8d53-b2782e44c650