Hyaluronic Acid-Coated Carbon Nonwoven Fabrics as Potential Material for Repair of Osteochondral Defects for medical applications

• Autorzy: Rajzer I. , Menaszek E. , Bacakova L. , Orzelski M. , Błażewicz M.

Warianty tytułu

PL

Włókniny węglowe modyfikowane kwasem hialuronowym jako potencjalne podłoża w leczeniu ubytków kostno-chrzęstnych

• Języki publikacji: EN

Abstrakty

EN

Damaged articular cartilage is known to have poor capacity for regeneration. Carbon fibres (CFs) have been widely investigated as cellular growth supports in cartilage tissue engineering. However, the long duration of the process of cartilage restoration limits the applicability of CFs implants in the treatment of cartilage tissue defects. Hyaluronic acid (HA) plays a key role in cartilage tissue development, repair and function. In the present study we focused on the in vitro and in vivo evaluation of two types of carbon nonwoven fabrics: HA modified and non-modified carbon nonwovens. The results of in vitro studies showed that cells attached well and retained their good viability in the carbon nonwoven matrix. The incorporation of hyaluronic acid resulted in the enhancement of cell proliferation. The results of in vivo studies showed a faster process of tissue regeneration in the case of HA modified carbon nonwovens. The results presented indicated that HA-modified carbon materials seem to be a suitable material for the treatment of osteochondral defects.

PL

Uszkodzona chrząstka stawowa posiada słabą zdolność do regeneracji. Od lat prowadzone są badania nad zastosowaniem włókien węglowych w inżynierii tkankowej chrząstki, jako podłoży podtrzymujących wzrost komórek. Niestety długi proces odbudowy chrząstki w obrębie implantu węglowego ogranicza możliwość zastosowania włóknin węglowych w leczeniu ubytków chrzęstnych. Kwas hialuronowy (HA) jest składnikiem chrząstki odpowiedzialnym za jej właściwy rozwój oraz proces regeneracji. Modyfikacja włóknin kwasem hialuronowym może w korzystny sposób wpłynąć na własności biologiczne implantów węglowych. W pracy przedstawiono wyniki badań in vitro oraz in vivo nad włókninami węglowymi modyfikowanymi kwasem hialuronowym oraz nad włókninami niemodyfikowanymi. Z przeprowadzonych badań in vitro wynika, że modyfikacja włóknin węglowych kwasem hialuronowym powoduje wzrost proliferacji komórek hodowanych na tych materiałach. Natomiast wyniki badań in vivo wykazały, że proces regeneracji tkanki następuje szybciej w przypadku włóknin węglowych modyfikowanych kwasem hialuronowym niż w przypadku włóknin niemodyfikowanych. Przeprowadzone badania wskazują, że włóknina węglowa modyfikowana kwasem hialuronowym może być rozważana jako potencjalny materiał w leczeniu ubytków kostno-chrzęstnych.

Słowa kluczowe

EN

cartilage; carbon fibres; nonwoven scaffolds; hyaluronic acid; biomaterials

PL

chrząstka; włókna węglowe; modyfikacja włóknin; kwas hialuronowy; biomateriały

• Wydawca: Sieć Badawcza Łukasiewicz - Łódzki Instytut Technologiczny
• Czasopismo: Fibres & Textiles in Eastern Europe
• Rocznik: 2013
• Tom: Vol. 21, no. 3 (99)
• Strony: 102--107
• Opis fizyczny: Bibliogr. 34 poz., rys., tab.

Twórcy

autor

Rajzer I.

• Institute of Textile Engineering and Polymer Materials, Faculty of Materials and Environment Science, University of Bielsko-Biala, Bielsko-Biała, Poland

autor

Menaszek E.

• Departament of Cytobiology, Collegium Medicum, UJ Jagiellonian University, Kraków, Poland
• Department of Biomaterials, Faculty of Materials Engineering and Ceramics, AGH – University of Science and Technology, Kraków, Poland

autor

Bacakova L.

• Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

autor

Orzelski M.

• Department and Clinic of Animal Surgery, Faculty of Veterinary Medicine, University of Life Sciences, Lublin, Poland

autor

Błażewicz M.

• Department of Biomaterials, Faculty of Materials Engineering and Ceramics, AGH – University of Science and Technology, Kraków, Poland

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