Chromatographic fingerprinting and quantitative analysis for the quality evaluation of Xinfeng capsule

• Autorzy: Gao Leilei , Wang Fang , Meng Mei

Identyfikatory

DOI

10.1556/1326.2020.00743

• Języki publikacji: EN

Abstrakty

EN

A simple, accurate and sensitive method of high performance liquid chromatography (HPLC）with diode array detector was established to identify Xinfeng capsules and systematically evaluated its quality, based on chromatographic fingerprint integrated with the similarity analysis, hierarchical cluster analysis and the quantitative analysis of multi-components by single marker (QAMS). In this study, 18 peaks were selected as the common peaks to evaluate the similarities among different batches (S1–S10) of Xinfeng capsules samples, which were manufactured in the First Affiliated Hospital of Anhui University of Chinese Medicine with a three-year span. Compared to control fingerprint, the similarities values for 10 batches of samples were more than 0.90. Moreover, by analyzing the reference of astragalus, the chromatogram of astragalus was developed, and 10 common peaks of astragalus were identified. More importantly, simultaneous quantification of three markers in Xinfeng capsule, including Calycosin-7-glucoside, calycosin and Formononetinaldehyde was performed, the three constituents showed good regression (R > 0.999) within linear ranges, and their recoveries were within the range of 97.6–101.5%. The validation results showed that the developed method was specific, accurate, precise and robust. This study demonstrated that the developed method offers an efficient, reliable and practical approach for systematic quality evaluation of Xinfeng capsule.

Słowa kluczowe

EN

HPLC; Xinfeng capsule; fingerprint; identification; quality control

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2021
• Tom: Vol. 33, no. 1
• Strony: 37--43
• Opis fizyczny: Bibliogr. 38 poz., rys., tab.

Twórcy

autor

Gao Leilei

• School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China

autor

Wang Fang

• College of Biotechnology and Pharmaceutical Engineering, West Anhui University, Lu’an, 237012, China
• The Provincial 2011 Collaborative Innovation Center of Anhui-Dendrobium Huoshanense Industrialization Exploitation Collaborative Innovation Center, Lu’an, 237012, China
• Key Laboratory of Xinan Medicine, Ministry of Education, State Administration of Traditional Chinese Medicine TCM Preparation Level 3 Laboratory, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, 230031, China

• https://orcid.org/0000-0002-6559-997X

autor

Meng Mei

• Key Laboratory of Xinan Medicine, Ministry of Education, State Administration of Traditional Chinese Medicine TCM Preparation Level 3 Laboratory, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, 230031, China

• https://orcid.org/0000-0003-4991-0876

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2021).