In silico validation of a customizable fully-autonomous artificial pancreas with coordinated insulin, glucagon and rescue carbohydrates

• Autorzy: Sanz Ricardo , Sala-Mira Iván , Furió-Novejarque Clara , García Pedro , Díez José-Luis , Bondia Jorge

Identyfikatory

DOI

10.1016/j.bbe.2024.08.003

• Języki publikacji: EN

Abstrakty

EN

Artificial pancreas systems should be designed considering different patient profiles, which is challenging from a control theory perspective. In this paper, a flexible-hybrid dual-hormone control algorithm for an artificial pancreas is proposed. The algorithm handles announced/unannounced meals by means of a non-interacting feedforward scheme that safely incorporates prandial boluses. Also, a coordination strategy is employed to distribute the counter-regulatory actions, which can be delivered as a continuous glucagon infusion via an automated pump, as an oral rescue carbohydrate recommendation, or as a rescue glucagon dose recommendation to be administrated through a glucagon pen. The different configurations of the proposed controller were evaluated in silico using a 14-day virtual scenario with random meal intakes and exercise sessions, achieving above 80% time-in-range and low time spent in hypoglycemia.

Słowa kluczowe

EN

type 1 diabetes; dual hormone artificial pancreas; exercise compensation; unannounced meals; postprandial control

PL

cukrzyca typu 1; sztuczna trzustka; kontrola poposiłkowa

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2024
• Tom: Vol. 44, no. 3
• Strony: 560--568
• Opis fizyczny: Bibliogr. 42 poz., rys., tab., wykr.

Twórcy

autor

Sanz Ricardo

• Instituto Universitario de Automática e Informática Industrial, Universitat Politčcnica de Valčncia, C/ Camí de Vera, s/n, Valčncia, 46022, Spain

autor

Sala-Mira Iván

• Instituto Universitario de Automática e Informática Industrial, Universitat Politčcnica de Valčncia, C/ Camí de Vera, s/n, Valčncia, 46022, Spain

autor

Furió-Novejarque Clara

• Instituto Universitario de Automática e Informática Industrial, Universitat Politčcnica de Valčncia, C/ Camí de Vera, s/n, Valčncia, 46022, Spain

autor

García Pedro

• Instituto Universitario de Automática e Informática Industrial, Universitat Politčcnica de Valčncia, C/ Camí de Vera, s/n, Valčncia, 46022, Spain
• Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Av. Monforte de Lemos, 3-5, Pabellón 11, Madrid, 28029, Spain

autor

Díez José-Luis

• Instituto Universitario de Automática e Informática Industrial, Universitat Politčcnica de Valčncia, C/ Camí de Vera, s/n, Valčncia, 46022, Spain
• Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Av. Monforte de Lemos, 3-5, Pabellón 11, Madrid, 28029, Spain

autor

Bondia Jorge

• Instituto Universitario de Automática e Informática Industrial, Universitat Politčcnica de Valčncia, C/ Camí de Vera, s/n, Valčncia, 46022, Spain
• Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Av. Monforte de Lemos, 3-5, Pabellón 11, Madrid, 28029, Spain

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa nr POPUL/SP/0154/2024/02 w ramach programu "Społeczna odpowiedzialność nauki II" - moduł: Popularyzacja nauki (2025).