Influence of PEG-coated Bismuth Oxide Nanoparticles on ROS Generation by Electron Beam Radiotherapy

Sisin, Noor Nabilah Talik; Anuar, Muhammad Afiq; Dollah, Norhayati; Razak, Khairunisak Abdul; Algethami, Merfat; Geso, Moshi; Rahman, Wan Nordiana

doi:10.2478/pjmpe-2022-0008

Artykuł - szczegóły

Tytuł artykułu

Influence of PEG-coated Bismuth Oxide Nanoparticles on ROS Generation by Electron Beam Radiotherapy

Autorzy

Sisin Noor Nabilah Talik , Anuar Muhammad Afiq , Dollah Norhayati , Razak Khairunisak Abdul , Algethami Merfat , Geso Moshi , Rahman Wan Nordiana

Wybrane pełne teksty z tego czasopisma

http://content.sciendo.com/view/journals/pjmpe/pjmpe-overview.xml

Identyfikatory

DOI

10.2478/pjmpe-2022-0008

Warianty tytułu

Języki publikacji

Abstrakty

Introduction: Nanoparticles (NPs) have been proven to enhance radiotherapy doses as radiosensitizers. The introduction of coating materials such as polyethylene glycol (PEG) to NPs could impact the NPs’ biocompatibility and their effectiveness as radiosensitizers. Optimization of surface coating is a crucial element to ensure the successful application of NPs as a radiosensitizer in radiotherapy. This study aims to investigate the influence of bismuth oxide NPs (BiONPs) coated with PEG on reactive oxygen species (ROS) generation on HeLa cervical cancer cell line. Material and methods: Different PEG concentrations (0.05, 0.10, 0.15 and 0.20 mM) were used in the synthesis of the NPs. The treated cells were irradiated with 6 and 12 MeV electron beams with a delivered dose of 3 Gy. The reactive oxygen species (ROS) generation was measured immediately after and 3 hours after irradiation. Results: The intracellular ROS generation was found to be slightly influenced by electron beam energy and independent of the PEG concentrations. Linear increments of ROS percentages over the 3 hours of incubation time were observed. Conclusions: Finally, the PEG coating might not substantially affect the ROS generated and thus emphasizing the functionalized BiONPs application as the radiosensitizer for electron beam therapy.

Słowa kluczowe

PEG bismuth oxide reactive oxygen species radiotherapy electron beam

Wydawca

Polskie Towarzystwo Fizyki Medycznej
De Gruyter

Czasopismo

Polish Journal of Medical Physics and Engineering

Rocznik

2022

Tom

Vol. 28, Iss. 2

Strony

69--76

Opis fizyczny

Bibliogr. 62 poz., rys.

Twórcy

autor

Sisin Noor Nabilah Talik

Medical Radiation Programme, School of Health Sciences, Universiti Sains Malaysia, Malaysia

https://orcid.org/0000-0003-1054-6173

autor

Anuar Muhammad Afiq

Faculty of Health and Life Sciences, Management and Science University, Malaysia
Medical Radiation Programme, School of Health Sciences, Universiti Sains Malaysia, Malaysia

https://orcid.org/0000-0001-5680-8584

autor

Dollah Norhayati

Department of Nuclear Medicine, Radiotherapy & Oncology, Hospital Universiti Sains Malaysia, Malaysia

autor

Razak Khairunisak Abdul

School of Materials and Mineral Resources Engineering, Universiti Sains Malaysia, Malaysia

https://orcid.org/0000-0003-0140-2418

autor

Algethami Merfat

Physics Department, Faculty of Science, Taif University, Saudi Arabia

https://orcid.org/0000-0001-6869-9143

autor

Geso Moshi

Medical Radiation Discipline, School Medical Sciences, RMIT University, Australia

autor

Rahman Wan Nordiana

Medical Radiation Discipline, School Medical Sciences, RMIT University, Australia

https://orcid.org/0000-0001-8386-0329

Bibliografia

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Uwagi

Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023).

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Bibliografia

Identyfikator YADDA

bwmeta1.element.baztech-9f51080b-4081-4442-922c-878282a6bbba