Physical properties of biodegradable polymers exposed to artificial plasma flow

• Autorzy: Zegartowska Alicja , Stojko Mateusz , Joszko Kamil , Goldsztajn Karolina , Orłowska Ada , Szewczenko Janusz

Identyfikatory

DOI

10.34821/eng.biomat.170.2023.9-13

• Języki publikacji: EN

Abstrakty

EN

Despite significant advances in diagnosis and treatment, cardiovascular disease remains a major cause of premature death. Approximately 80% of cardiovascular incidents can be prevented by optimizing risk factor control and lifestyle modification, including dietary change. Treatment of cardiovascular disease, like treatment of other diseases, can be divided into conservative and curative. Conservative treatment is based on pharmacotherapy, while surgical treatment is mainly based on the use of PCI (percutaneous coronary intervention) procedures, i.e., increasing blood flow through narrowed arteries. This effect can be achieved with stents. The main limitation of metal stents is their permanent presence within the body, which can lead to complications such as thrombosis. A more advanced solution is the use of polymer or drug-coated stents, both of which are made of biodegradable materials. These stents are designed to release medications to support treatment and maintain their shape within the blood vessel before being naturally absorbed and eliminated by the body. In this study, the surface of stents made of polylactide was modified by applying a layer of PLGA using an ultrasound method. The study was carried out for uncoated and coated stents in both the initial state and after exposure to artificial plasma flow. The scope of the work included microscopic observations, weight measurements of the specimen, and examination of radial forces. The analysis of the results showed no clear effect of exposure on stent weight, but a clear effect of long- -term exposure on radial forces was observed.

Słowa kluczowe

EN

bioresorbable stents; biodegradable coatings; poly(L-lactide-co-glycolide) (PLGA); splay coating; radial forces

PL

stenty; biomateriały; biodegradacja

• Wydawca: Polish Society for Biomaterials in Cracow
• Czasopismo: Engineering of Biomaterials
• Rocznik: 2023
• Tom: vol. 26, no. 170
• Strony: 9--13
• Opis fizyczny: Bibliogr. 12 poz., tab., wykr., zdj.

Twórcy

autor

Zegartowska Alicja

• Faculty of Biomedical Engineering, Silesian University of Technology, Franklina Roosevelta 40, 41-800 Zabrze, Poland

• https://orcid.org/0009-0000-7552-8617

autor

Stojko Mateusz

• Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Sklodowskiej 34, 41-819 Zabrze, Poland

• https://orcid.org/0000-0001-8868-9495

autor

Joszko Kamil

• Faculty of Biomedical Engineering, Silesian University of Technology, Franklina Roosevelta 40, 41-800 Zabrze, Poland

• https://orcid.org/0000-0002-8229-3032

autor

Goldsztajn Karolina

• Faculty of Biomedical Engineering, Silesian University of Technology, Franklina Roosevelta 40, 41-800 Zabrze, Poland

• https://orcid.org/0000-0003-2545-9339

autor

Orłowska Ada

• Faculty of Biomedical Engineering, Silesian University of Technology, Franklina Roosevelta 40, 41-800 Zabrze, Poland

• https://orcid.org/0000-0002-0168-7508

autor

Szewczenko Janusz

• Faculty of Biomedical Engineering, Silesian University of Technology, Franklina Roosevelta 40, 41-800 Zabrze, Poland

• https://orcid.org/0000-0001-9718-8617

Bibliografia

• [1] https://www.who.int/health-topics/cardiovascular-diseases #tab=tab_1
• [2] F. Otsuka, M. Nakano, F.D. Kolodgie, R. Virmani: Evaluation of Vulnerable Atherosclerotic Plaques. In: Coronary Artery Disease; Eds. T.J. Willerson, J.R.D. Holmes; Springer, London 2015.
• [3] B.J. Bachar, B. Manna: Coronary Artery Bypass Graft, National Library of Medicine, In: StatPearls. Treasure Island (FL): StatPearls Publishing 2023.
• [4] A. Guildford, M. Santin, G.J. Phillips: Cardiovascular stents. In: Biomaterials and Devices for the Circulatory System, University of Brighton, Woodhead Publishing Series in Biomaterials (2010) 173-216.
• [5] J. Marciniak: Stenty w chirurgii małoinwazyjnej, wyd. Politechniki Śląskiej, Gliwice 2006
• [6] M. Latos, A. Masek: Biodegradowalne poliestry. Instytut Technologii Polimerów i Barwników, Łódź 2017
• [7] I. Vroman, L. Tighzert: Biodegradable Polymers. Materials 2(2) (2009) 307-344.
• [8] H. Ding, Y. Zhang, Y. Liu, C. Shi, Z. Nie, H. Liu, Y. Gu: Analysis of Vascular Mechanical Characteristics after Coronary Degradable Stent Implantation. BioMed Research Interational (2019) 8265374.
• [9] R.C. Eberhart, S.-H. Su, K.T. Nguyen, M. Zilberman, L. Tang, K.D. Nelson, P. Frenkel: Bioresorbable polymeric stents: current status and future promise. Journal of Biomaterials Science, Polymer Edition 14(4) (2003) 299-312.
• [10] A. Foerster, M. Duda, H. Kraśkiewicz, M. Wawrzyńska, H. Podbielska, M. Kopaczyńska: Physico-chemical stent surface modifications. In: Functionalised Cardiovascular Stents, Eds. J.G. Wall, H. Podbielska, M. Wawrzyńska, Woodhead Publishing (2018) 137-148.
• [11] M.A. Sayed Patwary, S.M. Surid, M.A. Gafur: Properties and Applications of Biodegradable Polymers. Journal of Research Updates in Polymer Science 9 (2020) 32-41.
• [12] E. Vassallo, M. Pedroni, M. Aloisio, S.M. Pietralunga, R. Donnini, F. Saitta, D. Fessas: Plasma Treatment of Different Biodegradable Polymers: A Method to Enhanc Wettability and Adhesion Properties for Use in Industrial Packaging. Plasma 7(1) (2024) 91-105.

Uwagi

Opracowanie rekordu ze środków MNiSW, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2024).