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Monitorowanie aktywności proteolitycznej jako element diagnostyki chorób cywilizacyjnych

Treść / Zawartość
Identyfikatory
Warianty tytułu
EN
Proteolityc activity monitoring as an element of diagnostics of civilization diseases
Języki publikacji
PL
Abstrakty
EN
Proteolytic enzymes are essential for the proper functioning of every living cell. Due to their great importance in controlling metabolic changes in living organisms, they could be used in the diagnosis of civilization diseases. Hence, the search for new methods of determining and controlling their activity is extremely important. Our team, has been studying substrates of proteases and their potential use in detection of biomarkers activity for many years.
Rocznik
Strony
335--347
Opis fizyczny
Bibliogr. 44 poz., rys.
Twórcy
  • Wydział Chemii Uniwersytetu Gdańskiego, Ul. Wita Stwosza 63 80-308 Gdańsk
  • Wydział Chemii Uniwersytetu Gdańskiego, Ul. Wita Stwosza 63 80-308 Gdańsk
  • studentka Wydziału Chemii Uniwersytetu Gdańskiego, Ul. Wita Stwosza 63 80-308 Gdańsk
  • studentka Wydziału Chemii Uniwersytetu Gdańskiego, Ul. Wita Stwosza 63 80-308 Gdańsk
  • Wydział Chemii Uniwersytetu Gdańskiego, Ul. Wita Stwosza 63 80-308 Gdańsk
autor
  • Wydział Chemii Uniwersytetu Gdańskiego, Ul. Wita Stwosza 63 80-308 Gdańsk
Bibliografia
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  • [22] X. Tian, L.C. Murfin, L. Wu, S.E. Lewis, T.D. James, Fluorescent small organic probes for biosensing. Chem. Sci., 2021, 12, 3406.
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  • [26] S.S. Cotrin, L. Puzer, W.A. de Souza Judice, L. Juliano, A.K. Carmona, M.A. Juliano, Positional-scanning combinatorial libraries of fluorescence resonance energy transfer peptides to define substrate specificity of carboxydipeptidases: assays with human cathepsin B. Anal. Biochem., 2004, 335, 244.
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  • [29] J. Popow-Stellmaszyk, M. Wysocka, A. Lesner, B. Korkmaz, K. Rolka, A new proteinase 3 substrate with improved selectivity over human neutrophil elastase. Anal. Biochem., 2013, 442, 75.
  • [30] M. Łęgowska, Y. Hamon, A. Wojtysiak, R. Grzywa, M. Sieńczyk, T. Burster, B. Korkmaz, A. Lesner, Development of the first internally-quenched fluorescent substrates of human cathepsin C: The application in the enzyme detection in biological samples. Arch. Biochem. Biophys., 2016, 612, 91.
  • [31] N. Gruba, M. Wysocka, M. Brzezińska, D. Debowski, K. Rolka, N. I. Martin, A. Lesner, Novel internally quenched substrate of the trypsin-like subunit of 20S eukaryotic proteasome. Anal. Biochem., 2016, 508, 38.
  • [32] M. Wysocka, N. Gruba, R. Grzywa, A. Giełdoń, R. Bąchor, K. Brzozowski, M. Sieńczyk, J. Dieter, Z. Szewczuk, K. Rolka, A. Lesner, PEGylated substrates of NSP4 protease: A tool to study protease specificity. Sci. Rep., 2016, 6, 22856.
  • [33] M. Maślanka, A. Mucha, Recent Developments in Peptidyl Diaryl Phoshonates as Inhibitors and Activity-Based Probes for Serine Proteases. Pharmaceuticals (Basel, Switzerland), 2019, 12, 86.
  • [34] H. Fang, B. Peng, S. \Y. Ong, Q. Wu, L. Li, S.Q. Yao, Recent advances in activity-based probes (ABPs) and affinity-based probes (AfBPs) for profiling of enzymes. Chem. Sci., 2021, 12, 8288.
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  • [36] F. McNab, K. Mayer-Barber, A. Sher, A. Wack, A. O'Garra, Type I interferons in infectious disease. Nat. Rev. Immunol., 2015, 15, 87.
  • [37] N. Gruba, J. I. Rodriguez Martinez, R. Grzywa, M. Wysocka, M. Skoreński, M. Burmistrz, M. Łęcka, A. Lesner, M. Sieńczyk, K. Pyrć, Substrate profiling of Zika virus NS2B-NS3 protease. FEBS Lett., 2016, 590, 3459.
  • [38] N. Gruba, J. Martinez, R. Grzywa, M. Wysocka, M. Skoreński, A. Dabrowska, M. Łęcka, P. Suder, M. Sieńczyk, K. Pyrc, A. Lesner, One Step Beyond: Design of Substrates Spanning Primed Positions of Zika Virus NS2B-NS3 Protease. ACS Med. Chem. Lett., 2018, 9, 1025.
  • [39] N. Gruba, M. Wysocka, M. Brzezińska, D. Dębowski, M. Sieńczyk, E. Gorodkiewicz, T. Guszcz, C. Czaplewski, K. Rolka, A. Lesner, Bladder cancer detection using a peptide substrate of the 20S proteasome. FEBS J., 2016, 283, 2929.
  • [40] M. Wysocka, A. Romanowska, N. Gruba, M. Michalska, A. Giełdoń, A. Lesner, A Peptidomimetic Fluorescent Probe to Detect the Trypsin β2 Subunit of the Human 20S Proteasome. Int. J. Mol. Sci., 2020, 21, 2396.
  • [41] N. Gruba, P. Rachubik, A. Piwkowska, A. Lesner, Analysis of urinary kallikrein-related peptidase 13 for monitoring bladder cancer. Biomarkers., 2021, 26, 770.
  • [42] N. Gruba, L. Stachurski, A. Lesner, Elastolytic activity is associated with inflammation in bladder cancer. J. Biochem., 2021, 170, 547.
  • [43] N. Gruba, L. Stachurski, A. Lesner, Chemical tools to monitor bladder cancer progression. Biomarkers., 2022, 1. Advance online publication
  • [44] I. Audzeyenka, P. Rachubik, D. Rogacka, M. Typiak, T. Kulesza, S. Angielski, M. Rychłowski, M. Wysocka, N. Gruba, A. Lesner, M. A. Saleem, A. Piwkowska, Cathepsin C is a novel mediator of podocyte and renal injury induced by hyperglycemia. Biochim. Biophys. Acta Mol. Cell Res., 2020, 1867, 118723.
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-9da551ea-cb71-4256-9577-0ea4631a3eed
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