Bioaktywne peptydy z białek mleka ®

• Autorzy: Pluta Antoni Stanisław , Garbowska Monika , Stasiak-Różańska Lidia , Berthold-Pluta Anna

Warianty tytułu

EN

Bioactive peptides from milk proteins®

• Języki publikacji: PL

Abstrakty

PL

Najliczniejszymi białkami mleka są α-kazeina, β-kazeina, κ-kazeina, β-laktoglobulina i α-laktoalbumina. Poza wysoką wartością odżywczą, białka mleka mają ogromny wpływ na właściwości technologiczne mleka, takie jak między innymi: stabilność cieplną, podatność na koagulację pod wpływem podpuszczki, zdolności emulgujące czy pianotwórcze. Białka te są także głównym źródłem składników bioaktywnych w mleku. Bioaktywne peptydy pochodzące z białek mleka cieszą się dużym zainteresowaniem naukowym i aplikacyjnym ze względu na ich różnorodność i potencjalne korzyści zdrowotne. Peptydy te wykazują m.in. aktywność przeciwnadciśnieniową, immunomodulującą, przeciwnowotworową, przeciwzakrzepową, przeciwbakteryjną i cytotoksyczną. Ze względu na wiele znanych i domniemanych korzyści dla zdrowia ludzkiego, bioaktywne peptydy z mleka są stosowane jako składniki nutraceutyków.

EN

The most abundant milk proteins are α-casein, β-casein, κ-casein, β-lactoglobulin and α-lactalbumin. In addition to the high nutritional value, milk proteins have a huge impact on the technological properties of milk, such as, among others, heat stability, susceptibility to rennet coagulation, emulsifying and foaming abilities. These proteins are also the main source of bioactive ingredients in milk. Bioactive peptides derived from milk proteins are of great scientific and application interest due to their diversity and potential health benefits. These peptides show, inter alia, antihypertensive, immunomodulating, antitumor, anticoagulant, antibacterial and cytotoxic activity. Due to many known and alleged benefits to human health, bioactive milk peptides are used as ingredients in nutraceuticals.

Słowa kluczowe

PL

mleko; peptydy; bioaktywność; właściwości prozdrowotne

EN

milk; peptides; bioactivity; health-promoting properties

• Wydawca: Wyższa Szkoła Menadżerska
• Czasopismo: Postępy Techniki Przetwórstwa Spożywczego
• Rocznik: 2022
• Tom: nr 1
• Strony: 207--216
• Opis fizyczny: Bibliogr. 49 poz., fig., rys., tab.

Twórcy

autor

Pluta Antoni Stanisław

• Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Polska

• https://orcid.org/0000-0002-4405-6263

autor

Garbowska Monika

• Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Polska

• https://orcid.org/0000-0002-0827-8897

autor

Stasiak-Różańska Lidia

• Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Polska

• https://orcid.org/0000-0002-9682-3639

autor

Berthold-Pluta Anna

• Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Polska

• https://orcid.org/0000-0002-0822-2885

Bibliografia

• [1] ABD EL-SALAM M. H., S. EL-SHIBINY. 2013. “Bioactive Peptides of Buffalo, Camel, Goat, Sheep, Mare, and Yak Milks and Milk Products.” Food Reviews International 29: 1–23.
• [2] AHMED A. S., T. EL-BASSIONY, L. M. ELMALT, H. R. IBRAHIM. 2015. “Identification of potent antioxidant bioactive peptides from goat milk proteins.” Food Research International 74: 80–88.
• [3] AIHARA K., H. ISHII, M. YOSHIDA. 2009. “Casein-derived tripeptide, Val-Pro-Pro (VPP), modulates monocyte adhesion to vascular endothelium.” Journal of Atherosclerosis and Thrombosis 16: 594–603.
• [4] BELL S. J., G. T. GROCHOSKI, A. J. CLARKE. 2006. “Health implications of milk containing β-casein with the A2 genetic variant.” Critical Reviews in Food Science and Nutrition 46: 93–100.
• [5] BELTRÁN-BARRIENTOS L.M., A. HERNÁNDEZ-MENDOZA, M.J. TORRES LLANEZ, A. F. GONZÁLEZ-CÓRDOVA, B. VALLEJO-CÓRDOBA. 2016. “Fermented milk as antihypertensive functional food.” Journal of Dairy Science 99: 4099–4110.
• [6] BOUGLÉ D., S. BOUHALLAB. 2017. “Dietary bioactive peptides: Human studies.” Critical Reviews in Food Science and Nutrition 57: 335–343.
• [7] BRANTL V., H. TESCHEMACHER, J. BLÄSIG, A. HENSCHEN, F. LOTTSPEICH. 1981. “Opioid activities of β-casomorphins.” Life Sciences 28: 1903–1909.
• [8] CASTRO G. M. D., S. BOUHALLAB, V. SGARBIERI. 2009. “In vitro impact of a whey protein isolate (WPI) and collagen hydrolysates (CHs) on B16F10 melanoma cells proliferation.” Journal of Dermatological Science 56: 51–57.
• [9] CICERO A., F. AUBIN, V. AZAIS-BRAESCO, C. BORGHI. 2013. “Do the lactotripeptides isoleucineproline- proline and valine-proline-proline reduce systolic blood pressure in European subjects? A metaanalysis of randomized controlled trials.” American Journal of Hypertension 26: 442–449.
• [10] CLARE D., H. SWAISGOOD. 2000. „Bioactive milk peptides: a prospectus.” Journal of Dairy Science 83: 1187–1195.
• [11] DE NONI I., R. J. FITZGERALD, H. J. KORHONEN, Y. LE ROUX, C. T. LIVESEY, I. THORSDOTTIR, D. TOMÉ, R. WITKAMP. 2009. “Review of the potential health impact of β-casomorphins and related peptides.” EFSA Science Report 231: 1–107.
• [12] FAO 2013. FOOD AND AGRICULTURE ORGANIZATION OF THE UNITED NATIONS. “Milk and dairy product composition.” [In] Milk and dairy products on human nutrition. Rome, Italy.
• [13] FAOSTAT 2020. https://www.fao.org/faostat/ en/#data/QCL dostęp w dniu: 09.03.2022
• [14] GARBOWSKA M., A. PLUTA, A. BERTHOLDPLUTA. 2020. “Contents of functionally bioactive peptides, free amino acids, and biogenic amines in Dutch-Type cheese models produced with different lactobacilli.” Molecules 25: 5465.
• [15] GARBOWSKA M., A. PLUTA, A. BERTHOLDPLUTA. 2020. “Impact of nisin-producing strains of Lactococcus lactis on the contents of bioactive dipeptides, free amino acids, and biogenic amines in Dutch-Type cheese models.” Materials 13(8): 1–17.
• [16] GARG S., K. NURGALI, V. KUMAR MISHRA. 2016. “Food proteins as source of opioid peptides – a review.” Current Medicinal Chemistry 23: 893–910.
• [17] GAUTHIER S. F., Y. POULIOT, D. SAINTSAUVEUR. 2006. “Immunomodulatory peptides obtained by the enzymatic hydrolysis of whey proteins.” International Dairy Journal 16: 1315–1323.
• [18] GIACOMETTI J., A. BURETIĆ- TOMLJANOVIĆ. 2017. “Peptidomics as a tool for characterizing bioactive milk peptides.” Food Chemistry 230: 91–98.
• [19] HECK J., A. SCHENNINK, H. VAN VALENBERG, H. BOVENHUIS, M. VISKER, J. VAN ARENDONK, A. VAN HOOIJDONK. 2009. “Effects of milk protein variants on the protein composition of bovine milk.” Journal of Dairy Science 92: 1192–1202.
• [20] HERNÁNDEZ-CASTELLANO L. E., A. M. ALMEIDA, N. CASTRO, A. ARGÜELLO. 2014. “The colostrum proteome, ruminant nutrition and immunity: a review.” Current Protein and Peptide Science 15: 64–74.
• [21] IWANIAK A., D. MOGUT, P. MINKIEWICZ, J. ŻULEWSKA, M. DAREWICZ. 2021. “Gouda Cheese with Modified Content of β-Casein as a Source of Peptides with ACE – and DPP-IVInhibiting Bioactivity: A Study Based on In Silico and In Vitro Protocol.” International Journal of Molecular Sciences 22: 2949. doi.org/10.3390/ijms22062949.
• [22] LEE M., H. LEE, J. KIM. 2018. “Dairy food consumption is associated with a lower risk of the metabolic syndrome and its components: a systematic review and meta-analysis.” British Journal of Nutrition 120: 373–384.
• [23] LI Z., A. JIANG, T. YUE, J. WANG, Y. WANG, J. SU. 2013. “Purification and identification of five novel antioxidant peptides from goat milk casein hydrolysates.” Journal of Dairy Science 96(7): 4242– 4251.
• [24] LIU Z., C. C. UDENIGWE. 2019. “Role of foodderived opioid peptides in the central nervous and gastrointestinal systems.” Journal of Food Biochemistry 43: e12629.
• [25] MADUREIRA A. R., T. TAVARES, A. M. P. GOMES, M. E. PINTADO, F. X. MALCATA. 2010. “Invited review: physiological properties of bioactive peptides obtained from whey proteins.” Journal of Dairy Science 93: 437–455.
• [26] MARCONE S., O. BELTON, D. FITZGERALD. 2017. “Milk derived bioactive peptides and their health promoting effects: a potential role in atherosclerosis.” British Journal of Clinical Pharmacology 83: 152– 162.
• [27] MATHER I. H. 2000. “A review and proposed nomenclature for major proteins of the milk-fat globule membrane.” Journal of Dairy Science 83: 203–247.
• [28] MCGREGOR R. A., S. D. POPPITT. 2013. “Milk protein for improved metabolic health: a review of the evidence.” Nutrition and Metabolism 10: 46–59.
• [29] MENDIS S. 2017. “Global progress in prevention of cardiovascular disease.” Cardiovascular Diagnosis and Therapy 7: 32–38.
• [30] MURGIANO L., A. M. TIMPERIO, L. ZOLLA, S. BONGIORNI, A. VALENTINI, L. PARISET. 2009. “Comparison of milk fat globule membranę (MFGM) proteins of Chianina and Holstein cattle breed milk samples through proteomics methods.” Nutrients 1: 302–315.
• [31] MZ i NFZ 2018. SERWIS MINISTERSTWA ZDROWIA I NARODOWEGO FUNDUSZU ZDROWIA. https://pacjent.gov.pl/artykul/cukrzycaw- liczbach (dostęp w dniu 20.03.2022).
• [32] NEELIMA S. R., Y. RAJPUT, B. MANN. 2013. “Chemical and functional properties of glycomacropeptide (GMP) and its role in the detection of cheesewhey adulteration in milk: a review.” Dairy Science and Technology 93: 21–43.
• [33] NGUYEN D. D., F. BUSETTI, S. K. JOHNSON, V. A. SOLAH. 2015. “Identification and quantification of native beta-casomorphins in Australian milk by LC–MS/MS and LC–HRMS.” Journal of Food Composition and Analysis 44: 102–110.
• [34] NGUYEN D. D., S. K. JOHNSON, F. BUSETTI, V. A. SOLAH. 2015. “Formation and degradation of beta-casomorphins in dairy processing.” Critical Reviews in Food Science and Nutrition 55: 1955–1967.
• [35] ONG L., N. P. SHAH. 2008. “Release and identification of angiotensyn-converting enzyme-inhibitory peptides as influenced by ripening temperatures and probiotic adjuncts in Cheddar cheeses.” Journal of Food Science and Technology 41: 1555–1566.
• [36] PARK Y. W., M. S. NAM. 2015. “Bioactive peptides in milk and dairy products: a review.” Korean Journal of Food Science and Technology 35(6): 831–840.
• [37] PASIN G., K. B. COMERFORD. 2015. “Dairy foods and dairy proteins in the management of type 2 diabetes: a systematic review of the clinical evidence.” Advances in Nutrition 6: 245–259.
• [38] RICCI-CABELLO I., M. OLALLA HERRERA, R. ARTACHO. 2012. “Possible role of milk-derived bioactive peptides in the treatment and prevention of metabolic syndrome.” Nutrition Reviews 70: 241– 255.
• [39] RIVAL S. G., C. G. BOERIU, H. J. WICHERS. 2001. “Caseins and casein hydrolysates. 2. Antioxidative properties and relevance to lipoxygenase inhibition.” Journal of Agricultural and Food Chemistry 4: 295– 302.
• [40] RYAN J., R. ROSS, D. BOLTON, G. FITZGERALD, C. STANTON. 2011. “Bioactive peptides from muscle sources: meat and fish.” Nutrients 3: 765–791.
• [41] SAH B. N. P., T. VASILJEVIC, S. MCKECHNIE, O. N. DONKOR. 2015. “Identification of anticancer peptides from bovine milk proteins and their potential roles in management of cancer: a critical review”. Comprehensive Reviews in Food Science and Food Safety 14: 123–138.
• [42] SAHINGIL D., A. HAYALOGLU, H. KIRMACI, B. ÖZER, O. SIMSEK. 2014. “Changes of proteolysis and Angiotensin-I converting enzymeinhibitory activity in white-brined cheese as affected by adjunct culture and ripening temperature.” Journal of Dairy Research 81: 394–402.
• [43] SUMMER A., F. DI FRANGIA, P. A. MARSAN, I. DE NONI, M. MALACARNE. 2020. “Occurrence, biological properties and potential effects on human health of β-casomorphin 7: Current knowledge and concerns.” Critical Reviews in Food Science and Nutrition 60(21): 3705–3723.
• [44] SZERSZUNOWICZ I. 2014. “Wpływ peptydów bioaktywnych uwalnianych z białek mleka krowiego na układ krwionośny.” Innowacyjne Mleczarstwo 2(1): 4–12.
• [45] TIDONA F., A. CRISCIONE, A. M. GUASTELLA, A. ZUCCARO, S. BORDONARO, D. MARLETTA. 2009. “Bioactive peptides in dairy products.” Italian Journal of Animal Science 8: 315–340.
• [46] TYAGI A., E. BANAN-MWINE DALIRI, F. KWAMI OFOSU, Y. SU-JUNG, O. DEOGHWAN. 2020. “Food-Derived Opioid Peptides in Human Health: A Review.” International Journal of Molecular Science 21: 8825.
• [47] UCHIDA M., Y. OHSHIBA, O. MOGAMI. 2011. “Novel dipeptidyl peptidase-4-inhibiting peptide derived from β-lactoglobulin.” Journal of Pharmacology Science 117(1): 63–66.
• [48] UENISHI H., T. KABUKI, Y. SETO, Y. SERIZAWA, D. NAKAJIMA. 2012. “Isolation and identification of casein‐derived dipeptidyl‐peptidase 4 (DPP‐4)‐inhibitory peptide LPQNIPPL from goudatype cheese and its effect on plasma glucose in rats.” International Dairy Journal 22: 24–30.
• [49] VARGAS-BELLO-PÉREZ E., R. I. MÁRQUEZHERNÁNDEZ, L. E. HERNÁNDEZCASTELLANO. 2019. “Bioactive peptides from milk: animal determinants and their implications in human health.” Journal of Dairy Research 86: 136– 144.

Uwagi

Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023).