A tubular polycaprolactone/hyaluronic acid scaffolds for nasal cartilage tissue engineering

• Autorzy: Jatteau S. , Kurowska A. , Ziąbka M. , Rajzer I.
• Języki publikacji: EN

Abstrakty

EN

In this preliminary study, 3D nanofibrous porous scaffolds in the form of spiral tubes for future application as nasal cartilages implants were fabricated by combining polycaprolactone electrospun fibers with drug modified hyaluronic acid gel. It is expected that the spiral form of the scaffold with open geometries, large surface area, and distance between the scaffold walls will be helpful for improving future cell penetration into the scaffolds, nutrient transport and metabolic waste removal, which are otherwise limited in conventional electrospun tissue-engineered scaffolds. The tubular scaffolds structure, its porosity and fibers’ diameter were assessed via scanning electron microscopy, and biological properties of the scaffolds were evaluated in an in vitro study using Simulated Body Fluid (SBF). SEM results showed that apatite formed within a short period on tubular scaffolds after its immersion in SBF, demonstrating high in vitro bioactivity of the scaffolds.

Słowa kluczowe

EN

electrospinning; tissue engineering scaffolds; nasal cartilages; hyaluronic acid; PCL

• Wydawca: Polish Society for Biomaterials in Cracow
• Czasopismo: Engineering of Biomaterials
• Rocznik: 2017
• Tom: Vol. 20, no. 141
• Strony: 8--12
• Opis fizyczny: Bibliogr. 18 poz., rys., tab., zdj.

Twórcy

autor

Jatteau S.

• University of Lorraine, Polytech Nancy, Nancy 2 Rue Jean Lamour, 54519 Vandoeuvre-lès-Nancy, France

autor

Kurowska A.

• ATH University of Bielsko-Biala, Faculty of Mechanical Engineering and Computer Science, ul. Willowa 2, 43-309 Bielsko-Biała, Poland

autor

Ziąbka M.

• AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Ceramics and Refractories, Al. Mickiewicza 30, 30-059 Krakow, Poland

autor

Rajzer I.

• ATH University of Bielsko-Biala, Faculty of Mechanical Engineering and Computer Science, ul. Willowa 2, 43-309 Bielsko-Biała, Poland

Bibliografia

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Uwagi

Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2018).