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Lactoferrin, a glycoprotein found in milk, has stimulated osteoblast proliferation and differentiation, but has remained relatively unexplored as a biomaterial component. In this study, artificial extracellular matrices consisting of fibrils of collagen type I containing lactoferrin were used as coatings for the biocompatible polymer poly(lactic-co-glycolic acid) (PLGA). The numbers of cells, their viability and proliferation rate were evaluated in various time intervals. Additionally, cell initial spreading area on day 1 was measured. The results show that lactoferrin accelerates fibril-logenesis, leads to increased osteoblast cell numbers 1 and 3 days post-seeding, and encourages their proliferation in each of the tested time intervals.
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132--134
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Bibliogr. 10 poz., rys., wykr.
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autor
- Institute of Physiology, Academy of Sciences of the Czech Republic, Dept. of Biomaterials and Tissue Engineering, Prague, Czech Republic
autor
- Institute of Physiology, Academy of Sciences of the Czech Republic, Dept. of Biomaterials and Tissue Engineering, Prague, Czech Republic
autor
- Polymer Chemistry and Biomaterials (PBM) Group, Ghent University, Belgium
autor
- Polymer Chemistry and Biomaterials (PBM) Group, Ghent University, Belgium
Bibliografia
- [1] NOAT, D., et al. (2005) Clinical Medicine & Research 3, 93-101.
- [2] TAKAYAMA, Y., et al. (2008) Bioscience Biotechnology and Biochemistry. 72, 226-230.
- [3] TAKAYAMA, Y., et al. (2009) Journal of Bioscience and Bioengineering 107, 191-195.
- [4] VANDROVCOVA, M., et al. (2011) Physiological Research 60, 797-813.
- [5] KARAMICHOS, D., et al. (2006) Journal of Biomedical Materials Research Part A 78, 407-415.
- [6] CORNISH, J., et al. (2004) Endocrinology 149: 4366-4374.
- [7] CORNISH, J. NAOT, D. (2010) Biometals 23: 425-430.
- [8] GREY, A., et al. (2004) Molecular Endocrinology 18: 2268¬2278.
- [9] NAOT, D., et al. (2011) Bone 49: 217-224.
- [10] GREY, A., et al. (2006) Molecular and Cellular Endocrinology 251: 96-102.
Uwagi
EN
The authors acknowledge Research Foundation Flanders (FWO) for its support. Further support was provided by the by the Grant Agency of the Ministry of Health of the Czech Republic (Project No. NT 13297). We also thank Mr. Robin Healey (Czech Technical University, Prague) for his language revision of the text.
Typ dokumentu
Bibliografia
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