Hyperpolarized ¹³C tracers: Technical advancements and perspectives for clinical applications

• Autorzy: Fiedorowicz Michal , Wieteska Michal , Rylewicz Katarzyna , Kossowski Bartosz , Piątkowska-Janko Ewa , Czarnecka Anna M. , Toczylowska Beata , Bogorodzki Piotr

Identyfikatory

DOI

10.1016/j.bbe.2021.03.010

• Języki publikacji: EN

Abstrakty

EN

Hyperpolarized ¹³C tracers offer a radiation-free option for metabolic imaging. Signal enhancement of an order of several thousand times with the dynamic nuclear polarization (DNP) technique allows the detection of these tracers and their immediate metabolites in living organisms with MRI/MRSI (magnetic resonance imaging/magnetic resonance spectroscopy imaging) methods in real time and with high temporal resolution. The initial ‘target’ application for DNP hyperpolarized tracers was prostate cancer, a condition that could hardly be diagnosed with the FDG PET. However, several Phase 2 clinical trials currently involve not only patients with prostate cancer but also pancreatic cancer, amyotrophic lateral sclerosis, transient ischemic attack, glioblastoma multiforme, mycosis fungiodes (skin cancer), and chronic heart failure. A large number of trials that started in the last three years indicate that there could be a potential for the application of hyperpolarized ¹³C labeled pyruvate in the diagnosis of several conditions other than prostate cancer. One limitation for the hyperpolarized ¹³C-labelled tracers is their relatively short half-life. In this review, we discuss several emerging strategies for increasing tracer’s lifetime that could allow either their transportation between facilities or improve the signal-to-noise ratio in the final acquisition. We also discuss some promising diagnostic applications.

Słowa kluczowe

EN

dynamic nuclear polarization; metabolic imaging; DNP; MRI; MRSI; magnetic resonance imaging

PL

dynamiczna polaryzacja jądrowa; obrazowanie metaboliczne; DNP; MRI; MRSI; rezonans magnetyczny

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2021
• Tom: Vol. 41, no. 4
• Strony: 1466--1485
• Opis fizyczny: Bibliogr. 153 poz., rys., tab., wykr.

Twórcy

autor

Fiedorowicz Michal

• Small Animal Magnetic Resonance Imaging Laboratory, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland; Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland

autor

Wieteska Michal

• Small Animal Magnetic Resonance Imaging Laboratory, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland; Faculty of Electronics and Information Technology, Warsaw University of Technology, Warsaw, Poland

autor

Rylewicz Katarzyna

• Faculty of Medicine, Medical University of Warsaw, Warsaw, Poland

autor

Kossowski Bartosz

• Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland; Faculty of Electronics and Information Technology, Warsaw University of Technology, Warsaw, Poland; Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland

autor

Piątkowska-Janko Ewa

• Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland; Faculty of Electronics and Information Technology, Warsaw University of Technology, Warsaw, Poland

autor

Czarnecka Anna M.

• Department of Experimental Pharmacology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland; Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland

autor

Toczylowska Beata

• Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland

autor

Bogorodzki Piotr

• Small Animal Magnetic Resonance Imaging Laboratory, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland; Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland; Faculty of Electronics and Information Technology, Warsaw University of Technology, Warsaw, Poland

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