Eco-friendly based stability-indicating HPTLC technique for the determination of Escitalopram and Etizolam by employing quality by design approach

• Autorzy: Perumal Durgadevi , Krishnan Manikandan , Lakshmi K.S.

Identyfikatory

DOI

10.1556/1326.2023.01117

• Języki publikacji: EN

Abstrakty

EN

The two chemical components Escitalopram (ESC) and Etizolam (ETZ) are beneficial for the health of individuals because it helps to treat anxiety. The study mainly illustrated that a green approach is essential in the medical sector with the help of “Green Analytical quality by design”. According to AQbD, the techniques of HPTLC have become eco-friendly, and decided to use “ESC” and “ETZ”. Hence, ethanol and phosphate buffer pH 3.5 adjusted with 1% “orthophosphoric acid”. After the retardation factor, the product ESC was found at 0.34 min and ETZ was found at 0.53 min. The linearity of ETZ the range varies from 300 to 1800 μg mL1 and for ESC it varies from 100 to 600 μg mL1. The validation parameter of R2 Values ranged from 0.9997 to 0.9994 for both ESC and ETZ. The study also demonstrated that different other methods were also useful for the medical sector to make it more convenient and eco-friendly. Some of those approaches are “GAPI”, “AGMS”, “NEMI”, and “AGREE”. The outcome of the study helped to find that the technique “HPTLC” is a green analytic design that helps to maintain the stability of the medicine and it was also approved as a quality design and also a novel approach in the pharmaceutical sector.

Słowa kluczowe

EN

anti-anxiety; Green Analytical quality by design; degradation; ESC; HPTLC; ETZ; evaluation

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2024
• Tom: Vol. 36, no. 2
• Strony: 156--167
• Opis fizyczny: Bibliogr. 35 poz., rys., wykr.

Twórcy

autor

Perumal Durgadevi

• Department of Pharmaceutical Analysis, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur – 603203, Tamil Nadu, India

• https://orcid.org/0000-0002-0426-2716

autor

Krishnan Manikandan

• Department of Pharmaceutical Analysis, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur – 603203, Tamil Nadu, India

• https://orcid.org/0000-0001-7434-8067

autor

Lakshmi K.S.

• Department of Pharmaceutical Analysis, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur – 603203, Tamil Nadu, India

• https://orcid.org/0000-0002-3137-0990

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