Hydrogels based on ionically and covalently crosslinked alginates

• Autorzy: Walczak J. , Marchewka J. , Laska J.
• Konferencja: 24th Conference on Biomaterials in medicine and veterinary medicine : 9--12 October 2014, Rytro, Poland
• Języki publikacji: EN

Abstrakty

EN

In the presented research sodium alginate modified by ionic and covalent crosslinking in the form of hydrogel beads was examined. In the first step, sodium alginate was ionically crosslinked by treatment with calcium chloride. Different forms of crosslinked alginate were obtained depending on the calcium chloride concentration. The forms varied from shapeless gel to dense agglomerated spheres. The optimal structure were spherical beads separated from each other. Ionically crosslinked alginates were then subjected to covalent crosslinking with epichlorohydrin. For additional reinforcement the crosslinked beads of alginate were modified with cellulose nanofibers. The products were compared in terms of water absorption in the dry samples, their morphology was observed by scanning electron microscopy. Calcium ions distribution in the composites was evaluated by energy dispersive spectroscopy analysis. In vitro biodegradation of the crosslinked alginates was also investigated.

Słowa kluczowe

EN

hydrogels; alginate beads; crosslinking; cellulose

• Wydawca: Polish Society for Biomaterials in Cracow
• Czasopismo: Engineering of Biomaterials
• Rocznik: 2014
• Tom: Vol. 17, no. 128-129
• Strony: 109--110
• Opis fizyczny: Bibliogr. 3 poz.

Twórcy

autor

Walczak J.

• AGH University of Science and Technology, Faculty of Materials Science and Ceramics, 30 A.Mickiewicza Ave., 30-059 Krakow

autor

Marchewka J.

• AGH University of Science and Technology, Faculty of Materials Science and Ceramics, 30 A.Mickiewicza Ave., 30-059 Krakow

autor

Laska J.

• AGH University of Science and Technology, Faculty of Materials Science and Ceramics, 30 A.Mickiewicza Ave., 30-059 Krakow

Bibliografia

• [1] Jejurikar A., Lawrie G., Martin D, Grøndahl L.: A novel strategy for preparing mechanically robust ionically cross-linked alginate hydrogels. Biomedical Materials 6(2) (2011) 025010
• [2] Pal K., Banthia A.K., Majumdar D.K.: Polymeric Hydrogels: Characterization and Biomedical Applications - A mini review. Designed Monomers and Polymers 12 (2009) 197-220
• [3] Grasselli M., Diaz E.L., Cascone O.: Beaded matrices from cross-linked alginate for affinity and ion exchange chromatography of proteins. Biotechnology Techniques 7(10) (1993) 707-712

Uwagi

EN

The authors gratefully acknowledge the National Science Center (Poland) for financial support (grant no. 2011/01/B/STB8/07795).