Surfaktyna w technologii enkapsulacji : zastosowania farmaceutyczne i kosmetyczne

• Autorzy: Lewińska Agnieszka

Identyfikatory

DOI

10.53584/WIADCHEM.2025.11.10

Warianty tytułu

EN

Surfactin in encapsulation technology : pharmaceutical and cosmetic applications

• Języki publikacji: PL

Abstrakty

EN

The increasing demands for the efficacy, safety, and stability of biologically active compounds are driving the development of modern, targeted delivery systems. Traditional administration routes are increasingly being replaced by encapsulation technologies due to the pharmacokinetic limitations of active substances, such as low bioavailability, lack of selectivity, or toxicity. Encapsulating an active compound within an appropriate carrier protects it from degradation, enables selective action, and allows for the use of lower doses, which translates into improved safety profiles and economic benefits. These delivery strategies are widely applied not only in pharmaceuticals but also in cosmetology, where new formulations can be tested more easily and quickly. Of particular importance are colloidal carriers of nanometric size, whose stability largely depends on the presence of surfactants, amphiphilic compounds capable of stabilizing phase boundaries. Special attention is given to microbiologically derived biosurfactants, which, in addition to favorable physicochemical properties, also exhibit therapeutic activities, including antimicrobial and anticancer effects. The selected carrier systems presented: micelles, liposomes, polymer-based carriers, and nanoemulsions stabilized with surfactin offer promising solutions for the effective delivery of active compounds in both pharmaceutical and cosmetic applications.

Słowa kluczowe

PL

surfaktyna; enkapsulacja; nośnik; kosmetologia; farmacja

EN

surfactin; encapsulation; carrier; cosmetology; pharmacy

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Wiadomości Chemiczne
• Rocznik: 2025
• Tom: [Z] 79, 11-12
• Strony: 1097--1125
• Opis fizyczny: Bibliogr. 81 poz., rys., wykr.

Twórcy

autor

Lewińska Agnieszka

• Faculty University of Wrocław, Faculty of Chemistry, 14 Jolliot-Curie St., Wrocław PL-50-383, Poland

Bibliografia

• [1] N. V. Rao, J. G. Rho, W. Um, P. K. EK, V. Q. Nguyen, B. H. Oh, W. Kim and J. H. Park, Pharmaceutics, 2020, 12, 931.
• [2] S. A. Yousef, Y. H. Mohammed, S. Namjoshi, J. E. Grice, H. A. E. Benson, W. Sakran and M. S. Roberts, Pharmaceutics, 2019, 11, 639.
• [3] K.-A. Ryu, P. J. Park, S.-B. Kim, B.-H. Bin, D.-J. Jang and S. T. Kim, Pharmaceutics, 2020, 12, 332.
• [4] W. T. Ferreira, H. A. Hong, M. Hess, J. R. G. Adams, H. Wood, K. Bakun, S. Tan, L. Baccigalupi, E. Ferrari, A. Brisson, E. Ricca, M. Teresa Rejas, W. J. J. Meijer, M. Soloviev and S. M. Cutting, Pharmaceutics, 2021, 13, 1296.
• [5] I. M. Banat, A. Franzetti, I. Gandolfi, G. Bestetti, M. G. Martinotti, L. Fracchia, T. J. Smyth and R. Marchant, Appl Microbiol Biotechnol, 2010, 87, 427.
• [6] I. A. Phulpoto, Z. Yu, B. Hu, Y. Wang, F. Ndayisenga, J. Li, H. Liang and M. A. Qazi, Microb Cell Fact, 2020, 19, 1.
• [7] S. Shekhar, A. Sundaramanickam and T. Balasubramanian, Crit Rev Environ Sci Technol, 2015, 45, 1522.
• [8] S. Joshi, C. Bharucha and A. J. Desai, Bioresour Technol, 2008, 99, 4603.
• [9] M. Kowall, J. Vater, B. Kluge, T. Stein, P. Franke and D. Ziessow, J Colloid Interface Sci, 1998, 204, 1.
• [10] A. Bartal, A. Vigneshwari, B. Bóka, M. Vörös, I. Takács, L. Kredics, L. Manczinger, M. Varga, C. Vágvölgyi and A. Szekeres, Molecules, 2018, 23, 2675.
• [11] W.-Q. Qin, D. Fei, L. Zhou, Y.-J. Guo, S. An, O.-H. Gong, Y.-Y. Wu, J.-F. Liu, S.-Z. Yang and B.-Z. Mu, New Journal of Chemistry, 2023, 47, 7604.
• [12] J. ‐M Bonmatin, M. Genest, H. Labbé and M. Ptak, Biopolymers, 1994, 34, 975.
• [13] J.-M. Bonmatin, H. Labbé, I. Grangemard, F. Peypoux, R. Maget-Dana, M. Ptak and G. Michel, Letters in Peptide Science, 1995, 2, 41.
• [14] P. Tsan, L. Volpon, F. Besson and J. M. Lancelin, J Am Chem Soc, 2007, 129, 1968.
• [15] G. Seydlová and J. Svobodová, Cent Eur J Med, 2008, 3, 123.
• [16] H. Heerklotz and J. Seelig, Biophys J, 2001, 81, 1547.
• [17] C. M. Drouin and D. G. Cooper, Biotechnol Bioeng, 1992, 40, 86.
• [18] C. N. Mulligan and B. F. Gibbs, Journal of Chemical Technology & Biotechnology, 1990, 47, 23.
• [19] H. Razafindralambo, M. Paquot, C. Hbid, P. Jacques, J. Destain and P. Thonart, J Chromatogr A, 1993, 639, 81.
• [20] D. G. Cooper, C. R. Macdonald, S. J. B. Duff and N. Kosaric, Appl Environ Microbiol, 1981, 42, 408.
• [21] G. Viniegra-Gonzàlez, Advances in Solid State Fermentation, 1997, 5.
• [22] A. Berthod, T. Maryutina, B. Spivakov, O. Shpigun and I. A. Sutherland, Pure and Applied Chemistry, 2009, 81, 355.
• [23] I. A. Sutherland, J Chromatogr A, 2007, 1151, 6.
• [24] J. S. Jeon and C. Y. Kim, Sep Purif Technol, 2013, 105, 1.
• [25] M. Bochynek, P. Hodurek, M. Łukaszewicz and A. Lewińska, Biomass Convers Biorefin, 2023, 13, 16333.
• [26] J. D. Desai and I. M. Banat, Microbiology and Molecular Biology Reviews, 1997, 61, 47.
• [27] L. Thimon, F. Peypoux, R. Maget-Dana, B. Roux and G. Michel, Biotechnol Appl Biochem, 1992, 16, 144.
• [28] M. Kracht, H. Rokos, M. Özel, M. Kowall, G. Pauli and J. Vater, J Antibiot (Tokyo), 1999, 52, 613.
• [29] Y. Kameda, S. Ouhira, K. Matsui, S. Kanatomo, T. Hase and T. Atsusaka, Chem Pharm Bull (Tokyo), 1974, 22, 938.
• [30] J. D. Sheppard, C. Jumarie, D. G. Cooper and R. Laprade, Biochimica et Biophysica Acta (BBA) - Biomembranes, 1991, 1064, 13.
• [31] K. S. Rotondi and L. M. Gierasch, Peptide Science, 2005, 80, 374.
• [32] H. Heerklotz and J. Seelig, European Biophysics Journal, 2007, 36, 305.
• [33] Y. Liu, G. Yang, T. Baby, Tengjisi, D. Chen, D. A. Weitz and C. Zhao, Angewandte Chemie International Edition, 2020, 59, 4720.
• [34] M. Bochynek, A. Lewińska, M. Witwicki, A. Dębczak and M. Łukaszewicz, Front Bioeng Biotechnol. 2023, 11,1211319.
• [35] V. P. Torchilin, Pharm Res, 2006, 24, 1.
• [36] L. Sercombe, T. Veerati, F. Moheimani, S. Y. Wu, A. K. Sood and S. Hua, Front Pharmacol, 2015 6, 286
• [37] D. Velluto, C. Gasbarri, G. Angelini and A. Fontana, J Phys Chem B, 2011, 115, 8130.
• [38] Y. Nagawa and S. L. Regen, J Am Chem Soc, 1992, 114, 1668.
• [39] N. Anton, J.-P. Benoit and P. Saulnier, Journal of Controlled Release, 2008, 128, 185.
• [40] T. L. Moore, L. Rodriguez-Lorenzo, V. Hirsch, S. Balog, D. Urban, C. Jud, B. Rothen-Rutishauser, M. Lattuada and A. Petri-Fink, Chem Soc Rev, 2015, 44, 6287.
• [41] M. J. Santander-Ortega, A. B. Jódar-Reyes, N. Csaba, D. Bastos-González and J. L. Ortega-Vinuesa, J Colloid Interface Sci, 2006, 302, 522.
• [42] O. Sonneville-Aubrun, J.-T. Simonnet and F. L’Alloret, Adv Colloid Interface Sci, 2004, 108- 109, 145.
• [43] N. Usón, M. J. Garcia and C. Solans, Colloids Surf A Physicochem Eng Asp, 2004, 250, 415.
• [44] Mohamed S., El-Aasser; E. and David Sudol, JCT research, 2004, 1, 21.
• [45] Nakajima H., Industrial aplications of microemulsions: Microemulsions in cosmetics, 1997.
• [46] Solans C., Esquena J., Forgiarini A., Morales D., Usón N. and Izquierdo P, Surfactants in solution: fundamentals and applications; Nanoemulsions: formation and properties, New York, 2002.
• [47] S. Amselem and D. Friedman, in Submicron Emulsions in Drug Targeting and Delivery, CRC Press, 2019, 153.
• [48] T. Tadros, P. Izquierdo, J. Esquena and C. Solans, Adv Colloid Interface Sci, 2004, 108–109, 303.
• [49] E. J. Acosta and A. S. Bhakta, J Surfactants Deterg, 2009, 12, 7.
• [50] D. J. McClements, Food Emulsions, CRC Press, 2015.
• [51] D. Vollenbroich, G. Pauli, M. Özel and J. Vater, Appl Environ Microbiol, 1997, 63, 44.
• [52] Y. Xiong, J. Kong, S. Yi, X. Feng, Y. Duan and X. Zhu, Mol Pharm, 2020, 17, 2125.
• [53] A. Sharifian, J. Varshosaz, M. Aliomrani and M. Kazemi, Int J Pharm, 2023, 638, 122936.
• [54] R. Maget-Dana and M. Ptak, Biophys J, 1995, 68, 1937.
• [55] W. C. Zamboni, S. Ramalingam, D. M. Friedland, R. P. Edwards, R. G. Stoller, S. Strychor, L. Maruca, B. A. Zamboni, C. P. Belani and R. K. Ramanathan, Clinical Cancer Research, 2009, 15, 1466.
• [56] H. Zhang, G. Wang and H. Yang, Expert Opin Drug Deliv, 2011, 8, 171.
• [57] W. I. Goldburg, Am J Phys, 1999, 67, 1152.
• [58] R. Pecora, Journal of Nanoparticle Research, 2000, 2, 123.
• [59] J. Liu, A. Zou and B. Mu, Colloids Surf A Physicochem Eng Asp, 2010, 361, 90.
• [60] O. Bouffioux, A. Berquand, M. Eeman, M. Paquot, Y. F. Dufrêne, R. Brasseur and M. Deleu, Biochimica et Biophysica Acta (BBA) - Biomembranes, 2007, 1768, 1758.
• [61] B. R. Kang, J. S. Park, G. R. Ryu, W.-J. Jung, J.-S. Choi and H.-M. Shin, Nanomaterials, 2022, 12, 4189.
• [62] W. Huang, Y. Lang, A. Hakeem, Y. Lei, L. Gan and X. Yang, Int J Nanomedicine, 2018, Volume 13, 1723.
• [63] S. Soussi, R. Essid, I. Karkouch, H. Saad, S. Bachkouel, E. Aouani, F. Limam and O. Tabbene, Appl Biochem Biotechnol, 2021, 193, 3732.
• [64] Z. Liao, H. Wang, X. Wang, C. Wang, X. Hu, X. Cao and J. Chang, Colloids Surf A Physicochem Eng Asp, 2010, 370, 1.
• [65] A. Johnson, F. Kong, S. Miao, S. Thomas, S. Ansar and Z.-L. Kong, Nanomaterials, 2021, 11, 356.
• [66] R. Fopase, S. R. Pathode, S. Sharma, P. Datta and L. M. Pandey, Polymer-Plastics Technology and Materials, 2020, 59, 2076.
• [67] S. Beg, O. Afzal, I. Kazmi, A. G. Alkhathami, S. N. Mir Najib Ullah, M. Y. Alshahrani, S. S. Almujri, W. H. Almalki, A. S. Alfawaz Altamimi, A. Alzahrani, F. A. Al-Abbasi and M. Rahman, J Drug Deliv Sci Technol, 2023, 90, 105105.
• [68] A. Lewińska, M. Domżał-Kędzia, E. Maciejczyk, M. Łukaszewicz and U. Bazylińska, Int J Mol Sci, 2021,22, 10091.
• [69] A. Lewińska, Processes, 2021,9, 1180.
• [70] A. Lewińska, M. Domżał-Kędzia, A. Jaromin and M. Łukaszewicz, Pharmaceutics, 2020, 12, 1.
• [71] PL 241264B1, 2020.
• [72] US 12357555, 2025.
• [73] A. Lewińska, M. Domżał-Kędzia, K. Kierul, M. Bochynek, D. Pannert, P. Nowaczyk and M. Łukaszewicz, Molecules, 2021, 26, 1.
• [74] N. G. Ganesan and V. Rangarajan, Biocatal Agric Biotechnol, 2021, 33, 102001.
• [75] N. G. Ganesan, M. A. Miastkowska, J. Pulit-Prociak, P. Dey and V. Rangarajan, J Dispers Sci Technol, 2023, 44, 2045.
• [76] N. G. Ganesan, R. D. Singh and V. Rangarajan, Biomass Convers Biorefin, 2023, 15, 23897
• [77] N. G. Ganesan, R. D. Singh, D. Dwivedi and V. Rangarajan, J Clean Prod, 2023, 400, 136735.
• [78] Rishi Devendra Singh, N. G. Ganesan and V. Rangarajan, Colloid Journal, 2023, 85, 442.
• [79] M. Shan, F. Meng, C. Tang, L. Zhou, Z. Lu and Y. Lu, Colloids Surf B Biointerfaces, 2022, 215, 112521.
• [80] A. Lewińska, M. Domżał-Kędzia, K. Wójtowicz and U. Bazylińska, Colloids Surf A Physicochem Eng Asp, 2022, 648, 129216.
• [81] PL 245026B1, 2021.