Pharmacokinetics of ligustroflavone in rats and tissue distribution in mice by UPLC–MS/MS

• Autorzy: Zhou Quan , Zhang Zhiguang , Geng Peiwu , Huang Bingge , Wang Xianqin , Yu Xiaomin

Identyfikatory

DOI

10.1556/1326.2019.00586

• Języki publikacji: EN

Abstrakty

EN

An ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method was developed and validated for quantification of ligustroflavone, which was then applied in pharmacokinetics study in rat and tissue distribution in mouse. Twelve male Sprague Dawley rats were used for pharmacokinetics after intravenous (2 or 8 mg/kg) administration of ligustroflavone, six rats for each dose. Twenty-five mice were randomly divided into 5 groups (5 mice for each group, 1 group for each time point) and received 16 mg/kg ligustroflavone via intraperitoneal administration. The linear range of the calibration curve was over 2–2000 ng/mL for ligustroflavone in rat plasma and mouse tissues. The intra-day and inter-day precision expressed in % RSD were less than 14%, and the accuracy was between 88.5% and 108.4%.

Słowa kluczowe

EN

mouse; rat; UPLC/MS/MS; ligustroflavone; tissue distribution

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2020
• Tom: Vol. 32, no. 2
• Strony: 102--106
• Opis fizyczny: Bibliogr. 27 poz., rys.

Twórcy

autor

Zhou Quan

• Laboratory of Clinical Pharmacy, The People's Hospital of Lishui, Lishui 323000, China

autor

Zhang Zhiguang

• Wenzhou Medical University, Wenzhou 325035, China

autor

Geng Peiwu

• Laboratory of Clinical Pharmacy, The People's Hospital of Lishui, Lishui 323000, China

autor

Huang Bingge

• Wenzhou Medical University, Wenzhou 325035, China

autor

Wang Xianqin

• Wenzhou Medical University, Wenzhou 325035, China

autor

Yu Xiaomin

• Wenzhou Medical University, Wenzhou 325035, China

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Uwagi

PL

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2020).