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Tytuł artykułu

Evaluation of PCL and PCL/HAp scaffolds processed by electrospinning and porogen leaching techniques

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Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
In order to improve the pore size of the polycapro-lactone (PCL) and polycaprolactone/hydroxyapatite (PCL/HAp) nanofibrous scaffolds, salt-leaching technique together with electrospinning method were applied. Salt particles were incorporated within the polymer nanofibrous matrix and then were leached out to generate some macropores. Microstructure, pore size distribution and average fibre diameter of the scaffold were investigated by scanning electron microscopy and PMI capillary flow porometer. Mechanical properties were determined by means of tensile test. Presence of hydroxyapatite and chemical characterization of the scaffold were done by FTIR analysis.
Słowa kluczowe
Rocznik
Strony
4--7
Opis fizyczny
Bibliogr. 10 poz., wykr., zdj.
Twórcy
autor
  • ATH, University of Bielsko-Biala, Faculty of Materials and Environmental Sciences, Institute of Textile Engineering and Polymer Materials, Department of Polymer Materials, Willowa 2, 43-309 Bielsko-Biała, Poland
Bibliografia
  • [1] Zhang L., Webster T.J.: Nanotechnology and nanomaterials: Promises for improved tissue regeneration. Nano Today 4 (2009) 66-80.
  • [2] Sill T.J., von Recum H.A.: Electrospinning: Applications in drug delivery and tissue engineering. Biomaterials 29 (2008) 1989-2006.
  • [3] Woodruff M.A., HutmacherD.W.: The return of a forgotten polymer - Polycaprolactone in the 21st century. Progress in Polymer Science 35 (2010) 1217–1256.
  • [4] Sravanthi R.: Preparation and characterization of poly (ε-caprolactone) PCL scaffolds for tissue engineering applications. National Institute of Technology Rourkela (ORISSA). Thesis 2009.
  • [5] Fabbri P., Bondioli F., Messori M., Bartoli C., Dinucci D., Chiellini F.: Porous scaffolds of polycaprolactone reinforced with in situ generated hydroxyapatite for bone tissue engineering. Journal of Materials Science: Materials in Medicine 21 (2010) 343-351.
  • [6] LeeH.J., Kim S.E., Choi H.W., Kim C.W., Kim K.J., Lee S.C.: The effect of surface-modified nano-hydroxyapatite on biocompatibility of poly(ε-caprolactone)/hydroxyapatite nanocomposites.
  • [7] Liu X., Smith L.A., Hu J., Ma P.X.: Biomimetic nanofibrous gelatin/apatite composite scaffolds for bone tissue engineering. Biomaterials 30 (2009) 2252-2258.
  • [8] Bianco A., Federico E.D., Moscatelli I., Camaioni A., Armentano I., Campagnolo L., Dottori M., Kenny J.M., Siracusa G., Gusmano G.: Electrospun poly(ε-caprolactone)/Ca-deficient hydroxyapatite nanohybrids: Microstructure, mechanical properties and cell response by murine embryonic stem cells. Materials Science and Engineering C 29 (2009) 2063-2071.
  • [9] Agarwal S., Wendorff J.H., Greiner A.: Use of electrospinning technique for biomedical applications. Polymer 49 (2008) 5603-5621.
  • [10] Jang J.H., Castano O., Kim H.W.: Electrospun materials as potential platforms for bone tissue engineering. Advanced Drug Delivery Reviews 61(12) (2009) 1065-1083.
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-987d2a54-d0e2-4336-a399-c1db08d7d7dc
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