Effectiveness of Serial Casting Alone and in Combination with Botulinum Neurotoxin in Pediatric Spastic Cerebral Palsy Patients

• Autorzy: Argunsah Hande , Bentley Katherine , Androwis Ghaith , Higgins Laura , Nolan Karen

Identyfikatory

DOI

10.37190/ ABB-02310-2023-02

• Języki publikacji: EN

Abstrakty

EN

Purpose: This study evaluated the changes in gait of pediatric cerebral palsy patients after serial casting alone and serial casting in conjunction with botulinum neurotoxin treatments. Methods: Retrospective data of 31 children were investigated. Sixteen children were treated with serial casting combined with BoNT injection and 15 children were treated only with serial casting treatment. GAITRite was used to collect velocity, cadence, swing %, stance %, step length, stride length, and step time parameters to compare the outcomes of the treatments. Results: Combined treatment group unaffected side swing % showed a statistically significant difference at completion (M = 35.16 ±1.21; M = 32.46 ± 1.38; t (15) = 2.12, p = 0.049). Unaffected side stance % at pre-intervention was statistically different for serial casting only and the combined treatment groups (M = 61.69± 0.73; M = 64.88±1.20; t (14) = -2.273, p = 0.039). Pre- and post-intervention hemiplegic side swing % comparison was statistically significant for the serial casting only group (M = 40.87± 0.57; M = 42.39±0.79, t (14) = - 0.151, p = 0.032). The baseline velocity of the combined treatment group was slower than the serial casting-only group (88±11.2 vs. 107±14.4 (cm/s), p=0.007). Conclusions: This investigation suggests that for patients, who have poor ambulation quality, abnormal spatiotemporal gait parameters, and significant spasticity at pre-intervention, BoNT in conjunction with serial casting is more effective for improving ambulation quality. Serial casting can be used in conjunction with botulinum neurotoxin, which is efficient in muscle morphology and function regulation by reducing spasticity.

Słowa kluczowe

EN

botulinum neurotoxin; cerebral palsy; gross motor functional classification; serial casting; spasticity

• Wydawca: Oficyna Wydawnicza Politechniki Wrocławskiej
• Czasopismo: Acta of Bioengineering and Biomechanics
• Rocznik: 2023
• Tom: Vol. 25, no. 3
• Opis fizyczny: Bibliogr. 30 poz., tab.

Twórcy

autor

Argunsah Hande

• Acıbadem Mehmet Ali Aydınlar University, Istanbul, Turkey
• Kessler Foundation, Human Performance and Engineering Research, West Orange, New York, USA

autor

Bentley Katherine

• Children’s Specialized Hospital, Mountainside, New York, USA

autor

Androwis Ghaith

• Kessler Foundation, Human Performance and Engineering Research, West Orange, New York, USA

autor

Higgins Laura

• Children’s Specialized Hospital, Mountainside, New York, USA

autor

Nolan Karen

• Kessler Foundation, Human Performance and Engineering Research, West Orange, New York, USA

Bibliografia

• [1]. Ackman JD, Russman BS, Thomas SS, Buckon CE, Sussman MD, Masso P, Sanders J, D'Astous J, Aiona MD; Shriners Hospitals BTX-A Study Group. Comparing botulinum toxin A with casting for treatment of dynamic equinus in children with cerebral palsy. Dev Med Child Neurol. 2005 Sep;47(9):620-7. PMID: 16138670.
• [2]. Almina S, Karile Y, Audrone P, Indre B. Analgesic effect of botulinum toxin in children with cerebral palsy: A systematic review. Toxicon. 2021 Aug;199:60-67. doi: 10.1016/j.toxicon.2021.05.012.
• [3]. Blumetti FC, Belloti JC, Tamaoki MJ, Pinto JA. Botulinum toxin type A in the treatment of lower limb spasticity in children with cerebral palsy. Cochrane Database Syst Rev. 2019 Oct 8;10(10):CD001408. doi: 10.1002/14651858.CD001408.pub2.
• [4]. Blumetti FC, Belloti JC, Tamaoki MJ, Pinto JA. Botulinum toxin type A in the treatment of lower limb spasticity in children with cerebral palsy. Cochrane Database Syst Rev. 2019 Oct 8;10(10):CD001408. doi: 10.1002/14651858.CD001408.pub2.
• [5]. Bonikowski M, Sławek J. Safety and efficacy of Botulinum toxin type A preparations in cerebral palsy - an evidence-based review. Neurol Neurochir Pol. 2021;55(2):158- 164. doi: 10.5603/PJNNS.a2021.0032.
• [6]. Booth MY, Yates CC, Edgar TS, Bandy WD. Serial casting vs combined intervention with botulinum toxin A and serial casting in the treatment of spastic equinus in children. Pediatr Phys Ther. 2003 Winter;15(4):216-20. doi: 10.1097/01.PEP.0000096382.65499.E2.
• [7]. Cahlin BJ, Lindberg C, Dahlström L. Cerebral palsy and bruxism: Effects of botulinum toxin injections-A randomized controlled trial. Clin Exp Dent Res. 2019 Jun 29;5(5):460-468. doi: 10.1002/cre2.207.
• [8]. Dursun N, Gokbel T, Akarsu M, Bonikowski M, Pyrzanowska W, Dursun E. Intermittent serial casting for wrist flexion deformity in children with spastic cerebral palsy: a randomized controlled trial. Dev Med Child Neurol. 2021 Jun;63(6):743-747. doi: 10.1111/dmcn.14765.
• [9]. Farag SM, Mohammed MO, El-Sobky TA, ElKadery NA, ElZohiery AK. Botulinum Toxin A Injection in Treatment of Upper Limb Spasticity in Children with Cerebral Palsy: A Systematic Review of Randomized Controlled Trials. JBJS Rev. 2020 Mar;8(3):e0119. doi: 10.2106/JBJS.RVW.19.00119.
• [10]. Fathi M, Hussein AS, M Elghazaly S, Al-Kinawy AM, Abdeltawab AK, Mansour YM, Elbehbeh NA, Sherif A, Afifi AM. Effect of Botulinum Toxin on Equinus Foot Deformity in Cerebral Palsy Patients: A Systematic Review and Network Metaanalysis. Curr Pharm Des. 2020;26(37):4796-4807. doi: 10.2174/1381612826666200518105633.
• [11]. Franzén M, Hägglund G, Alriksson-Schmidt A. Treatment with Botulinum toxin A in a total population of children with cerebral palsy - a retrospective cohort registry study. BMC Musculoskelet Disord. 2017 Dec 11;18(1):520. doi: 10.1186/s12891-017- 1880-y.
• [12]. Gulati S, Sondhi V. Cerebral Palsy: An Overview. Indian J Pediatr. 2018 Nov;85(11):1006-1016. doi: 10.1007/s12098-017-2475-1.
• [13]. Hägglund G, Hollung SJ, Ahonen M, Andersen GL, Eggertsdóttir G, Gaston MS, Jahnsen R, Jeglinsky-Kankainen I, Nordbye-Nielsen K, Tresoldi I, Alriksson-Schmidt AI. Treatment of spasticity in children and adolescents with cerebral palsy in Northern Europe: a CP-North registry study. BMC Neurol. 2021 Jul 12;21(1):276. doi: 10.1186/s12883-021-02289-3.
• [14]. Lee SJ, Sung IY, Jang DH, Yi JH, Lee JH, Ryu JS. The effect and complication of botulinum toxin type a injection with serial casting for the treatment of spastic equinus foot. Ann Rehabil Med. 2011 Jun;35(3):344-53. doi: 10.5535/arm.2011.35.3.344.
• [15]. Mathevon L, Bonan I, Barnais JL, Boyer F, Dinomais M. Adjunct therapies to improve outcomes after botulinum toxin injection in children: A systematic review. Ann Phys Rehabil Med. 2019 Jul;62(4):283-290. doi: 10.1016/j.rehab.2018.06.010.
• [16]. Milne N, Miao M, Beattie E. The effects of serial casting on lower limb function for children with Cerebral Palsy: a systematic review with meta-analysis. BMC Pediatr. 2020 Jul 2;20(1):324. doi: 10.1186/s12887-020-02122-9.
• [17]. Multani I, Manji J, Hastings-Ison T, Khot A, Graham K. Botulinum Toxin in the Management of Children with Cerebral Palsy. Paediatr Drugs. 2019 Aug;21(4):261- 281. doi: 10.1007/s40272-019-00344-8.
• [18]. Multani I, Manji J, Tang MJ, Herzog W, Howard JJ, Graham HK. Sarcopenia, Cerebral Palsy, and Botulinum Toxin Type A. JBJS Rev. 2019 Aug;7(8):e4. doi: 10.2106/JBJS.RVW.18.00153.
• [19]. Nicolini-Panisson RD, Tedesco AP, Folle MR, Donadio MVF. Selective Dorsal Rhizotomy in Cerebral Palsy: Selection Criteria and Postoperative Physical Therapy Protocols. Rev Paul Pediatr. 2018 Jan 15;36(1):9. doi: 10.1590/1984- 0462/;2018;36;1;00005.
• [20]. Park ES, Rha DW, Yoo JK, Kim SM, Chang WH, Song SH. Short-term effects of combined serial casting and botulinum toxin injection for spastic equinus in ambulatory children with cerebral palsy. Yonsei Med J. 2010 Jul;51(4):579-84. doi: 10.3349/ymj.2010.51.4.579.
• [21]. Pérez-de la Cruz S. Childhood cerebral palsy and the use of positioning systems to control body posture: Current practices. Neurologia. 2017 Nov-Dec;32(9):610-615. English, Spanish. doi: 10.1016/j.nrl.2015.05.008.
• [22]. Rosenbaum P, Paneth N, Leviton A, Goldstein M, Bax M, Damiano D, Dan B, Jacobsson B. A report: the definition and classification of cerebral palsy April 2006. Dev Med Child Neurol Suppl. 2007 Feb;109:8-14. Erratum in: Dev Med Child Neurol. 2007 Jun;49(6):480. PMID: 17370477.
• [23]. Sadowska M, Sarecka-Hujar B, Kopyta I. Cerebral Palsy: Current Opinions on Definition, Epidemiology, Risk Factors, Classification and Treatment Options. Neuropsychiatr Dis Treat. 2020 Jun 12;16:1505-1518. doi: 10.2147/NDT.S235165.
• [24]. Schweizer M, Eylon S, Katz-Leurer M. The correlation between rhythm perception and gait characteristics at different rhythms among children with cerebral palsy and typically developing children. Gait Posture. 2020 Oct;82:83-89. doi: 10.1016/j.gaitpost.2020.08.120.
• [25]. Shoval H, Friel K, Levin J, Kim H. Cumulative Efficacy of Longitudinal Repeat Salivary Gland OnabotulinumtoxinA Injection: A Retrospective Study. Am J Phys Med Rehabil. 2021 Aug 1;100(8):798-802. doi: 10.1097/PHM.0000000000001675.
• [26]. Shoval H, Levin J, Friel K, Kim H. Safety of combined salivary gland and multilevel intramuscular onabotulinumtoxinA injections with and without ethanol in pediatric patients with cerebral palsy: A retrospective study. J Pediatr Rehabil Med. 2019;12(2):189-196. doi: 10.3233/PRM-180552.
• [27]. Thorley M, Donaghey S, Edwards P, Copeland L, Kentish M, McLennan K, Lindsley J, Gascoigne-Pees L, Sakzewski L, Boyd RN. Evaluation of the effects of botulinum toxin A injections when used to improve ease of care and comfort in children with cerebral palsy whom are non-ambulant: a double blind randomized controlled trial. BMC Pediatr. 2012 Aug 9;12:120. doi: 10.1186/1471-2431-12-120.
• [28]. Wesseling M, Kainz H, Hoekstra T, Van Rossom S, Desloovere K, De Groote F, Jonkers I. Botulinum toxin injections minimally affect modelled muscle forces during gait in children with cerebral palsy. Gait Posture. 2020 Oct;82:54-60. doi: 10.1016/j.gaitpost.2020.08.122.
• [29]. Yadav S, Chand S, Majumdar R, Sud A. Effect of botulinum toxin type-A in spasticity and functional outcome of upper limbs in cerebral palsy. J Clin Orthop Trauma. 2020 Mar-Apr;11(2):208-212. doi: 10.1016/j.jcot.2020.01.002.
• [30]. Yiğitoğlu P, Kozanoğlu E. Effectiveness of electrical stimulation after administration of botulinum toxin in children with spastic diplegic cerebral palsy: A prospective, randomized clinical study. Turk J Phys Med Rehabil. 2019 Feb 4;65(1):16-23. doi: 10.5606/tftrd.2019.2236.

Uwagi

Opracowanie rekordu ze środków MNiSW, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2024).

Brak numeracji stron