Antiradical properties of chemo drug, carboplatin, in cooperation with ZnO nanoparticles under UV irradiation in putative model of cancer cells

• Autorzy: Pairoj Suttirak , Damrongsak Pattareeya , Damrongsak Badin , Jinawath Natini , Kaewkhaw Rossukon , Leelawattananon Tanaporn , Ruttanasirawit Chinnapat , Locharoenrat Kitsakorn

Identyfikatory

DOI

10.1016/j.bbe.2019.08.004

• Języki publikacji: EN

Abstrakty

EN

The main objective of this study was to assess the antiradical properties of zinc oxide (ZnO) nanoparticles upon exposure to ultraviolet radiation with carboplatin, an anti-proliferative drug used in the treatment of retinoblastoma. For the purpose of this study, the decomposition of 2,2(diphenyl-1-picryhydrazyl) radical (DPPH*) was used to assess the free radical capacity of antioxidants and was followed by MTT measurements. To test the antiradical capacity, the effective concentration, antiradical power, stoichiometry, and number of reduced DPPH* were investigated. DPPH* has a peak absorbance at a wavelength of 515 nm, which disappears upon the introduction of the antiradical agents. Four agents were reacted with DPPH* and represented the possible reaction kinetic categories. ZnO nanoparticles and carboplatin-loaded ZnO nanoparticles reacted more strongly with DPPH* and approached a saturation state at 420 min. The remaining two antiradical agents, ZnO nanoparticles under UV radiation and carboplatin-loaded ZnO nanoparticles under UV radiation, reacted a bit slower with DPPH* and approached a steady state at 1440 min. Among the different four antiradical agents, carboplatin-loaded ZnO nanoparticles under UV light had the highest antiradical response with the lowest effective concentration value to the reduced DPPH* molecules. ZnO nanoparticles alone were found to be poor antiradical agent. Possible mechanisms were attributed to the number of hydroxyl groups available to decrease the number of DPPH*.

Słowa kluczowe

EN

antioxidant; chemotherapy; DPPH; nanoparticle; tumor

PL

antyoksydant; chemioterapia; DPPH; nanocząstka; nowotwór

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2019
• Tom: Vol. 39, no. 3
• Strony: 893--901
• Opis fizyczny: Bibliogr. 31 poz., rys., tab., wykr.

Twórcy

autor

Pairoj Suttirak

• Biomedical Physics Research Unit, Department of Physics, Faculty of Science, King Mongkut's Institute of Technology Ladkrabang, Bangkok, Thailand

autor

Damrongsak Pattareeya

• Biomedical Physics Research Unit, Department of Physics, Faculty of Science, King Mongkut's Institute of Technology Ladkrabang, Bangkok, Thailand

autor

Damrongsak Badin

• Department of Physics, Faculty of Science, Silpakorn University, Nakornpathom, Thailand

autor

Jinawath Natini

• Program in Translational Medicine, Faculty of Medicine Ramathibodi Hospital, Bangkok, Thailand

autor

Kaewkhaw Rossukon

• Program in Translational Medicine, Faculty of Medicine Ramathibodi Hospital, Bangkok, Thailand

autor

Leelawattananon Tanaporn

• Biomedical Physics Research Unit, Department of Physics, Faculty of Science, King Mongkut's Institute of Technology Ladkrabang, Bangkok, Thailand

autor

Ruttanasirawit Chinnapat

• Biomedical Physics Research Unit, Department of Physics, Faculty of Science, King Mongkut's Institute of Technology Ladkrabang, Bangkok, Thailand

autor

Locharoenrat Kitsakorn

• Biomedical Physics Research Unit, Department of Physics, Faculty of Science, King Mongkut's Institute of Technology Ladkrabang, Bangkok 10520, Thailand

Bibliografia

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Uwagi

PL

Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2019).