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The separation of microscale HA in aqueous solution by foam separation technique

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Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Hyaluronic acid (HA) has important applications in fields of health care products, cosmetics and clinical medical. However, the unique physiological properties of HA make cost of its traditional separation and extraction process relatively high. Foam separation technique has simple, gentle and efficient advantages on the separation of substances with surface activity by using bubbles as the separation medium. In this paper, natural surfactant CocamideBetaine (CAPB) was used as a foaming agent to explore the technology of microscale HA in aqueous solution by foam separation. The optimum process conditions were determined based on the recovery rate and enrichment ratio of HA by single factor and orthogonal experiment: at room temperature, pH = 7, separating air velocity (v) = 350 mL/min, HA concentration (CHA) = 50 mg/L, adding liquid volume (V) = 200 mL, collecting time (tcol) = 10 min, CAPB concentration (CCAPB) = 0.035 g/L. Under these conditions, HA enrichment ratio (E) equals 6.821 and HA recovery rate (R) equals 66.425%.
Rocznik
Strony
66--71
Opis fizyczny
Bibliogr. 18 poz., rys., tab.
Twórcy
autor
  • Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, P.R. China
autor
  • Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, P.R. China
autor
  • Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, P.R. China
autor
  • Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, P.R. China
autor
  • Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, P.R. China
autor
  • Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, P.R. China
Bibliografia
  • 1. Alcantara C.E.P. Castro M.A.A. De Noronha M.S. Martins P.A. Mendes R.D. Caliari M.V. Mesquita R.A. & Ferreira A.J.(2018). Hyaluronic acid accelerates bone repair in human dental sockets: a randomized triple-blind clinical trial. Brazilian Oral Research 32. DOI: 10.1590/1807-3107bor-2018.vol32.0084.
  • 2. Fondi K. Wozniak P.A. Schmidl D. Bata A.M. Witkowska K.J. Popa-Cherecheanu A. Schmetterer L. & Garhofer G.(2018). Effect of Hyaluronic Acid/Trehalose in Two Different Formulations on Signs and Symptoms in Patients with Moderate to Severe Dry Eye Disease. J. Ophthalmology. DOI: 10.1155/2018/4691417.
  • 3. Zhang B. Thayaparan A. Horner N. Bedi A. Alolabi B. & Khan M.(2019). Outcomes of hyaluronic acid injections for glenohumeral osteoarthritis: a systematic review and meta-analysi. J. Shoulder Elbow Surgery 28 596–606. DOI: 10.1016/j.jse.2018.09.011.
  • 4. Lu L. Zhang C.W. Li L.H. & Zhou C.R. (2013). Reversible pH-responsive aggregates based on the self-assembly of functionalized POSS and hyaluronic acid. Carbohydrate Polymers 94 444–448. DOI: 10.1016/j.carbpol.2013.01.061.
  • 5. Silva E.C.E. Omonte S.V. Martins A.G.V. De Castro H.H.O. Gomes H.E. Zenobio E.G. De Oliveira P.A.D. Horta M.C.R. & Souza P.E.A.(2017). Hyaluronic acid on collagen membranes: An experimental study in rats Archives of Oral Biology 73 214–222. DOI: 10.1016/j.archoralbio.2016.10.016.
  • 6. Ryabina V.R. Vasyukov S.E. Panov V.P. & Starodybtsev S.G.(1987). OBTAINING PROPERTIES AND APPLICATION OF HYALURONIC-ACID (A REVIEW). Khimiko-Farmatsevticheskii Zhurnal 21 142–154. DOI: 10.1002/chin.198736384.
  • 7. Necas J.J. Bartosikova L. & Brauner P. (2008). Hyaluronic acid (hyaluronan):A review. Veterinární Medicína 53(8). DOI: 10.17221/1930-VETMED.
  • 8. Zhu Y.Q. Wang X.X. Chen J. Zhang J. Meng F.H. Deng C. Cheng R. Feijen J. & Zhong Z.Y. (2016). Bio-responsive and fluorescent hyaluronic acid-iodixanol nanogels for targeted X-ray computed tomography imaging and chemotherapy of breast tumors. J. Controlled Release 244, 229–239. DOI: 10.1016/j.jconrel.2016.08.027.
  • 9. Wan L. Jiao J. Cui Y. Guo J.W. Han N. Di D.H. Chang D. Wang P. Jiang T.Y. & Wang S.L.(2016). Hyaluronic acid modified mesoporous carbon nanoparticles for targeted drug delivery to CD44-overexpressing cancer cells. Nanotechnology 27. DOI: 10.1088/0957-4484/27/13/135102.
  • 10. Huber-Vorlander J. & Kurten M.(2015). Correction of tear trough deformity with a cohesive polydensified matrix hyaluronic acid: a case series. Clini. Cosmetic and Investigational Dermatology 8 307–312. DOI: 10.2147/CCID.S84117.
  • 11. Xu K. Lee F. & Gao S.J.(2013). Injectable hyaluronic acidtyramine hydrogels incorporating interferon-α2a for liver-cancer therapy. J. Control Release 166, 203–210. DOI: 10.1016/j.jconrel.2013.01.008.
  • 12. Fan Y. Yao J. & Du R.(2013). Ternary complexes with core-shellbilayer for double level targeted gene delivery: in vitro andin vivo evaluation. Pharm. Res. 30 1215–1227. DOI: 10.1007/s11095-012-0960-9.
  • 13. Li B.B. Xu Q.N. Li X.F. Zhang P. Zhao X. & Wang Y.X.(2019). Redox-responsive hyaluronic acid nanogels for hyperthermia-assisted chemotherapy to overcome multi-drug resistance. Carbohydrate Polymers 203 378–385. DOI: 10.1016/j.carbpol.2018.09.076.
  • 14. Choi K.Y. Saravanakumar G. & Park J.H.(2012). Hyaluronicacid-based nanocarriers for intracellular targeting: interfacialinteractions with proteins in cancer. Colloids Surf BBiointerfaces 99: 82–94. DOI: 10.1016/j.colsurfb.2011.10.029.
  • 15. Ouasti S. Kingham P.J. & Terenghi G.(2012). The CD44/integrinsinterplay and the significance of receptor binding and representation in the uptake of RGD-functionalized hyaluronicacid. Biomaterials 33 1120–1134. DOI: 10.1016/j.biomaterials.2011.10.009.
  • 16. Cifonelli J.A. & Mayeda M.(1957). The purification of hyaluronic acid by the use of charcol. Biochim Biophys Acta 24(2), 397–400. DOI: 10.1016/0006-3002(57)90211-1.
  • 17. Choi K.Y. Jeon E.J. & Yoon H.Y.(2012). Theranostic nanoparticlesbased on PEGylated hyaluronic acid for the diagnosis therapyand monitoring of colon cancer. Biomaterials 33 6186–6193. DOI: 10.1016/j.biomaterials.2012.05.029.
  • 18. Li J. Huo M. & Wang J.(2012). Redox-sensitive micelles selfassembled from amphiphilic hyaluronic acid-deoxycholic acidconjugates for targeted intracellular delivery of paclitaxel. Biomaterials 33 2310–2320. DOI: 10.1016/j.biomaterials.2011.11.022.
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-959b6d74-6b8d-4e32-9185-f5c8230b8aaa
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