New instrumental criterion for evaluating the potential of injectable scaffolds for biomedical engineering applications

• Autorzy: Rył Anna , Owczarz Piotr

Identyfikatory

DOI

10.24425/cpe.2023.144695

• Języki publikacji: EN

Abstrakty

EN

When designing injectable scaffolds for biomedical applications, it is crucial to determine the conditions for the formation of unlimited structures, in particular the kinetics at constant temperature. Despite many studies, these conditions have not been characterized so far after injection, which is such an important application aspect. The aim of the research is to discuss the impact of the injection application on the polymer structure and to propose new criteria for assessing the potential of thermosensitive biopolymer sols, considering the flow under high shear rates during the administration. Based on the analysis of the obtained results of rheological tests, it was shown that the flow through the needles causes a significant change in the elastic properties that define the polymer structure, with almost unchanged viscous properties. As a consequence, the parameters characterizing the polymer coil change, which, combined with the quantitatively proven fragmentation, indicates that injection application may affect the size of the coils that will not reach the critical size of the aggregating nucleus. Finally, extended research procedures for the conscious design of injectable scaffolds are proposed as well as key rheological parameters to ensure thermoinduced aggregation preceded by shear during injection are provided.

Słowa kluczowe

EN

injectable scaffolds; hydrogels; sol-gel phase transition

PL

hydrożel

• Wydawca: Komitet Inżynierii Chemicznej i Procesowej Polskiej Akademii Nauk
• Czasopismo: Chemical and Process Engineering : New Frontiers
• Rocznik: 2023
• Tom: Vol. 44, nr 2
• Strony: art. no. e9
• Opis fizyczny: Bibliogr. 20 poz., rys., tab.

Twórcy

autor

Rył Anna

• Lodz University of Technology, Department of Chemical Engineering, Wolczanska 213, 93-005 Lodz, Poland

• https://orcid.org/0000-0003-1741-7905

autor

Owczarz Piotr

• Lodz University of Technology, Department of Chemical Engineering, Wolczanska 213, 93-005 Lodz, Poland

• https://orcid.org/0000-0002-3754-3899

Bibliografia

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Uwagi

Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023).