Exploration of simultaneous dual-isotope imaging with multiphoton modular J-PET scanner

• Autorzy: Beyene Ermias Y. , Das Manish , Durak-Kozica Martyna , Korcyl Grzegorz , Mryka Wiktor , Niedźwiecki Szymon , Parzych Szymon , Tayefi Keyvan , Walczak Rafał , Wawrowicz Kamil , Stępien Ewa , Moskal Pawel

Identyfikatory

DOI

10.5604/01.3001.0054.1940

• Języki publikacji: EN

Abstrakty

EN

The modular J-PET scanner, comprising 24 compact and versatile modules, each consisting of 13 plastic strips with four SiPM detectors at the ends, represents a powerful tool for clinical applications in nuclear medical imaging. This study presents preliminary results from the exploration of simultaneous dual-isotope imaging using the modular J-PET system. Our approach involved two isotopes: ⁶⁸Ge, characterized by a ringlike shape, and ²²Na, exhibiting a point-like shape. The imaging was based on double-coincidence and triple-coincidence events. In the double coincidence case, both isotopes contributed comparably, whereas in the triple coincidence case ²²Na dominated due to the prompt gamma being emitted with 100% of positron emissions, unlike ⁶⁸Ga, where the prompt gamma was emitted in only 1.3% of cases after positron emission. In this work we present direct 2γ images determined for two-signal events and images for three-signal events, with two signals from annihilation photons and one from a prompt gamma. These results showcase the preliminary findings from simultaneous dual-isotope imaging of ⁶⁸Ga and ²²Na isotopes using the modular J-PET scanner, which will be presented and discussed.

Słowa kluczowe

EN

dual isotope imaging; β+ imaging; γ imaging; 2γ imaging; medical imaging; J-PET; PET; multiphoton PET

• Wydawca: Uniwersytet Jagielloński - Collegium Medicum ; Index Copernicus Sp. z o.o.
• Czasopismo: Bio-Algorithms and Med-Systems
• Rocznik: 2023
• Tom: Vol. 19, no. 1
• Strony: 101--108
• Opis fizyczny: Bibliogr. 33 poz., rys.

Twórcy

autor

Beyene Ermias Y.

• Doctoral School of Exact and Natural Science, Jagiellonian University, Krakow, Poland
• Department of Experimental Particle Physics and Applications, Jagiellonian University in Krakow, Krakow, Poland
• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Krakow, Poland
• Centre for Theranostics, Jagiellonian University, Krakow, Poland

• https://orcid.org/0009-0002-8757-2169

autor

Das Manish

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Krakow, Poland
• Centre for Theranostics, Jagiellonian University, Krakow, Poland

• https://orcid.org/0009-0001-2901-1745

autor

Durak-Kozica Martyna

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Krakow, Poland
• Centre for Theranostics, Jagiellonian University, Krakow, Poland

• https://orcid.org/0000-0002-5275-6462

autor

Korcyl Grzegorz

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Krakow, Poland
• Centre for Theranostics, Jagiellonian University, Krakow, Poland

• https://orcid.org/0000-0001-6244-7287

autor

Mryka Wiktor

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Krakow, Poland
• Centre for Theranostics, Jagiellonian University, Krakow, Poland

• https://orcid.org/0009-0006-7616-8290

autor

Niedźwiecki Szymon

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Krakow, Poland
• Centre for Theranostics, Jagiellonian University, Krakow, Poland

• https://orcid.org/0000-0002-5953-9479

autor

Parzych Szymon

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Krakow, Poland
• Centre for Theranostics, Jagiellonian University, Krakow, Poland

autor

Tayefi Keyvan

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Krakow, Poland
• Centre for Theranostics, Jagiellonian University, Krakow, Poland

• https://orcid.org/0000-0001-8764-1588

autor

Walczak Rafał

• Institute of Nuclear Chemistry and Technology, Centre of Radiochemistry and Nuclear Chemistry, Warsaw, Poland

• https://orcid.org/0000-0002-0308-7223

autor

Wawrowicz Kamil

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Krakow, Poland
• Centre for Theranostics, Jagiellonian University, Krakow, Poland

• https://orcid.org/0000-0003-3818-5840

autor

Stępien Ewa

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Krakow, Poland
• Centre for Theranostics, Jagiellonian University, Krakow, Poland

• https://orcid.org/0000-0003-3589-1715

autor

Moskal Pawel

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Krakow, Poland
• Centre for Theranostics, Jagiellonian University, Krakow, Poland

• https://orcid.org/0000-0002-4229-3548

Bibliografia

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• 2. Moskal P, Niedźwiecki S, Bednarski T, Czerwiński E, Kubicz E, Moskal I, et al. Test of a single module of the J-PET scanner based on plastic scintillators. Nucl Instrum Methods Phys Res A. 2014;764:317-21.
• 3. Moskal P, Kowalski P, Shopa RY, Raczyński L, Baran J, Chug N, et al. Simulating NEMA characteristics of the modular total-body J-PET scanner-an economic total-body PET from plastic scintillators. Phys Med Biol. 2021;66(17):175015.
• 4. Niedźwiecki S, Białas P, Curceanu C, Czerwiński E, Dulski K, Gajos A, et al. J-PET: a new technology for whole-body PET imaging. Acta Phys Pol B. 2017;48:1567.
• 5. Korcyl G, Białas P, Curceanu C, Czerwiński E, Dulski K, Flak B, et al. Evaluation of single-chip, real-time tomographic data processing on FPGA SoC devices. IEEE Trans Med Imaging. 2018;37(11):2526-35.
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• 7. Moskal P, Dulski K, Chug N, Curceanu C, Czerwiński E, Dadgar M, et al. Positronium imaging with the novel multiphoton PET scanner. Sci. Adv. 2021;7(42):eabh4394.
• 8. Moskal P, Kisielewska D, Curceanu C, Czerwiński E, Dulski K, Gajos A, et al. Feasibility study of positronium imaging with the J-PET tomograph. Phys Med Biol. 2019;64(5):055017.
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• 16. Shimazoe K, Uenomachi M. Multi-molecule imaging and inter-molecular imaging in nuclear medicine. Bio-Algorithms Med Systems.2022;18(1):127-34.
• 17. Uenomachi M, Shimazoe K, Takahashi H. A double photon coincidence detection method for medical gamma-ray imaging. Bio-Algorithms Med-Systems. 2022;18(1):120-6.
• 18. Moskal P, Alfs D, Bednarski T, Białas P, Czerwiński E, Curceanu C, et al. Potential of the J-PET detector for studies of discrete symmetries in decays of positronium atom-a purely leptonic system. Acta Physica Polonica B. 2016;47(2): 509-35.
• 19. Brzezinski KW, Baran J, Borys D, Gajewski J, Chug N, Coussat A, et al. Detection of range shifts in proton beam therapy using the J-PET scanner: a patient simulation study. Phys Med Biol. 2023;68:145016.
• 20. Sharma S, Kacprzak K, Dulski K, Niedźwiecki S, Moskal P. Potential of modular J-PET for applications in the field of particle and medical physics. J Phys Conf Ser. 2022;2374(1):012040.
• 21. Sitarz M, Cussonneau JP, Matulewicz T, Haddad F. Radionuclide candidates for β+ + γ coincidence PET: an overview. Appl Radiat Isot. 2020;155:108898.
• 22. Matulewicz T. Radioactive nuclei for β+ + γ PET and theranostics: selected candidates. Bio-Algorithms Med-Systems. 2021;17(4):235-9.
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Uwagi

Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023).