Nanofibrous membranes loaded with bupivacaine and carica papaya extract for pain management and wound healing in postoperative wounds

• Autorzy: Zhang Aiqin , Hussain Shaik Althaf , Alrubie Turki Mayudh , Jiang Rong

Identyfikatory

DOI

10.2478/msp-2024-0019

• Języki publikacji: EN

Abstrakty

EN

The pursuit of effective paint management and would healing strategies within modern medicine remains a challenge. Postoperative skin injuries arising from surgeries and traumatic incidents often bring substantial discomfort, necessitating interventions that combine optimal pain relief with accelerated wound recovery. In this research, bupivacaine and carica papaya extract were loaded into polycaprolactone/polyvinyl alcohol membranes in order to develop a pain-relieving wound dressing material for pain management and skin wound healing after surgeries. The in vitro experiments were used to characterize the pain-relieving scaffold. An in vivo study of the excisional wound was carried out in a rat model. Histopathological examinations, wound closure studies, and pain-related behavioral factors were utilized to assess the in vivo pain management and wound healing efficacy of the dressings. Results showed that our developed constructs were not toxic and modulated inflammatory responses. In vivo study showed that this system could successfully close wounds and decrease the sensitivity of animals to painful stimuli. These wound dressings may potentially be considered dual function wound dressings to treat skin injuries.

Słowa kluczowe

EN

bupivacaine; carica papaya extract; wound dressing; drug delivery; nanofibers

• Wydawca: De Gruyter
• Czasopismo: Materials Science Poland
• Rocznik: 2024
• Tom: Vol. 42, No. 2
• Strony: 143--159
• Opis fizyczny: Bibliogr. 42 poz., rys.

Twórcy

autor

Zhang Aiqin

• Department of Anesthesiology, Gansu Third People’s Hospital Lanzhou, China

autor

Hussain Shaik Althaf

• Department of Zoology, College of Science, King Saud University Riyadh, Saudi Arabia

autor

Alrubie Turki Mayudh

• Department of Zoology, College of Science, King Saud University Riyadh, Saudi Arabia

autor

Jiang Rong

• Department of Anesthesiology, Ankang Central Hospital Ankang, China

Bibliografia

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