Substrate inhibition in lipase-catalysed transesterification of mandelic acid with vinyl acetate

• Autorzy: Dąbkowska K. , Pilarek M. , Szewczyk K. W.
• Języki publikacji: EN

Abstrakty

EN

Kinetic resolution of (R)- and (S)-mandelic acid by its transesterification with vinyl acetate catalysed by Burholderia cepacia lipase has been studied. The influence of the initial substrate concentration on the kinetics of process has been investigated. A modified ping-pong bi-bi model of enzymatic transesterification of (S)-mandelic acid including substrate inhibition has been developed. The values of kinetic parameters of the model have been estimated. We have shown that the inhibition effect revealed over a certain threshold limit value of the initial concentration of substrate.

Słowa kluczowe

EN

kinetic resolution; enantiomers; kinetic model; lipase; substrate inhibition

PL

rezolucja kinetyczna; enancjomery; model kinetyczny; lipazy; inhibicja substratem

• Wydawca: Komitet Inżynierii Chemicznej i Procesowej Polskiej Akademii Nauk
• Czasopismo: Chemical and Process Engineering
• Rocznik: 2012
• Tom: Vol. 33, nr 4
• Strony: 539--546
• Opis fizyczny: Bibliogr. 17 poz., tab., rys.

Twórcy

autor

Dąbkowska K.

• Warsaw University of Technology, Faculty of Chemical and Process Engineering, Department of Biotechnology and Bioprocess Engineering, Waryńskiego 1, 00-645 Warszawa, Poland

autor

Pilarek M.

• Warsaw University of Technology, Faculty of Chemical and Process Engineering, Department of Biotechnology and Bioprocess Engineering, Waryńskiego 1, 00-645 Warszawa, Poland

autor

Szewczyk K. W.

• Warsaw University of Technology, Faculty of Chemical and Process Engineering, Department of Biotechnology and Bioprocess Engineering, Waryńskiego 1, 00-645 Warszawa, Poland

Bibliografia

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