Synteza i aktywność biologiczna pochodnych pirolo [3,4-c]pirydyny

• Autorzy: Wójcicka A.

Warianty tytułu

EN

Synthesis and biological activity of pyrrolo[3,4-c]pyridine derivatives

• Języki publikacji: PL

Abstrakty

EN

Pyrrolo[3,4-c]pyridine is one of the six structural isomers of the bicyclic ring system containing pyrrole moiety condensed with a pyridine nucleus. This review presents most of the literature data about synthetic pyrrolo[3,4-c]pyridine derivatives and their biological activity. S. Gabriel and J. Colman [4] discovered this isomer for the first time and named it “merimine” [Fig. 3]. The main goal of this study is the presentation of various methods for the preparation of pyrrolo[3,4-c]pyridine derivatives. Compounds containing the pyrrolo[3,4-c]pyridine scaffold can be synthesized from different substrates, but the syntheses may be classified into two main categories: annulation of pyrrole ring onto pyridine derivatives or annulation of pyridine ring onto pyrrole derivatives. Biological investigations have shown that pyrrolo[3,4-c]pyridine derivatives have a wide spectrum of actions. Most of them have been studied as analgesic and sedative agents [35–40]. Antitumor [19, 42, 45], antiviral [27], antituberculostatic [43] activities have been found. Pyrrolo[3,4-c]pyridine derivatives can also be used in the treatment of nervous [20, 41] and immune [19, 42] system diseases.

Słowa kluczowe

PL

pochodne pirolo[3,4-c]pirydyny; synteza; aktywność biologiczna

EN

pyrrolo[3,4-c]pyridine derivatives; synthesis; biological activity

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Wiadomości Chemiczne
• Rocznik: 2013
• Tom: [Z] 67, 3-4
• Strony: 251--276
• Opis fizyczny: Bibliogr. 45 poz., schem.

Twórcy

autor

Wójcicka A.

• Katedra i Zakład Technologii Leków, Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, pl. Nankiera 1, 50-140 Wrocław

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