HPLC monitoring of the microsomal stability of rutin and quercetin

• Autorzy: Szőke É , Petroianu G. , Tekes K. , Benkő B , Szegi P. , Laufer R. , Veress G
• Języki publikacji: EN

Abstrakty

EN

Reversed-phase HPLC has been used to monitor the concentration of the two major Chamomile components rutin and quercetin during rat liver microsomal treatment. The possibility of microsomal oxidative metabolism or stability of these two components was examined using a guard-column without any clean-up. The concentration of quercetin decreased when exposed to rat liver microsomal media whereas the rutin concentration did not change significantly over one hour of treatment.

Słowa kluczowe

EN

HPLC; rutin; quercetin; rat liver microsomes; UV detection

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2009
• Tom: Vol. 21, no. 3
• Strony: 399--410
• Opis fizyczny: Bibliogr. 18 poz., rys., tab.

Twórcy

autor

Szőke É

• Semmelweis University Department of Pharmacognosy Budapest Hungary

autor

Petroianu G.

• Florida International University Department of Cell Biology Miami FL USA

autor

Tekes K.

• Semmelweis University Department of Pharmacodynamics Nagyvárad tér 4 1089 Budapest Hungary

autor

Benkő B

• Division of Pharmacology and Drug Safety Richter Gedeon Rt. Budapest Hungary

autor

Szegi P.

• Semmelweis University Department of Pharmacodynamics Nagyvárad tér 4 1089 Budapest Hungary

autor

Laufer R.

• Semmelweis University Department of Pharmacology and Pharmacotherapy Budapest Hungary

autor

Veress G

• State Cardiology Hospital Balatonfüred Hungary

Bibliografia

• [1] R.P. Webster, M.D. Gawde, and R.K. Bhattacharya, Cancer Lett., 109 , 185 (1996)
• [2] K. Ishizawa, Y. Izawa-Ishizawa, S. Ohnishi, Y. Motobayashi, K. Kawazoe, S. Hamano, K. Tsuchiya, S. Tomita, K. Minakuchi, and T. Tamaki, J. Pharm. Sci., 109 , 257 (2009)
• [3] J.S. Choi, S.W. Kang, J.L. Kim, J.Y. Bae, D.S. Kim, S.Y. Shin, J.G. Jun, M.H. Wang, and Y.H. Kang, J. Agric. Food Chem., PMID 19196000, Epub 2009
• [4] D.L. Attarde, V.M. Aurangabadkar, D.P. Belsare, and S.C. Pal, Pak. J. Pharm. Sci., 21 , 316 (2008)
• [5] E. Mincsovics, E. Tyihák, J. Nagy, and H. Kalász, Acta Hortic., 96 , 181 (1980)
• [6] E. Tyihák, E. Mincsovics, P. Tétényi, I. Zámbó, and H. Kalász, Acta Hortic., 96 , 113 (1980)
• [7] K. Keppler, E.M. Hein, and H.U. Humpf, Mol. Nutr. Food Res., 50 , 686 (2006)
• [8] X.J. Tan, Q. Li, X.H. Chen, Z.W. Wang, Z.Y. Shi, K.S. Bi, and Y. Jia., J. Pharm. Biomed. Anal., 47 , 847 (2008)
• [9] I. Novak, P. Janeiro, M. Seruga, and A.M. Oliveira-Brett, Anal. Chim. Acta, 630 , 107 (2008)
• [10] F. Zhang, Y. Yang, P. Su, and Z. Guo, Phytochem. Anal., 20 , 33 (2009)
• [11] R. Haruenkit, S. Poovarodom, H. Leontowicz, M. Leontowicz, M. Sajewicz, T. Kowalska, E. Delgado-Licon, N.E. Rocha-Guzmán, J.A. Gallegos-Infante, S. Trakhtenberg, and S. Gorinstein, J. Agric. Food Chem., 55 , 5842 (2007)
• [12] R. Chirinos, I. Betalleluz-Pallardel, A. Huamán, C. Arbizu, R. Pedreschi, and D. Campos, Food Chem., 113 , 1243, (2009)
• [13] H.Y. Cheung and Q.F. Zhang, J. Chromatogr. A, 1213 , 231 (2008)
• [14] M. Polásek, I. Petriska, M. Pospísilová, and L. Jahodár, Talanta, 69 , 192 (2006)
• [15] R. Veberic, J. Jakopic, F. Stampar, and V. Schmitzer, Food Chem., 114 , 511 (2009)
• [16] V.M. Savov, A.S. Galabov, L.P. Tantcheva, M.M. Mileva, L.L. Pavlova, E.S. Stoeva, and A.A. Braykova, Exp. Toxicol. Pathol., 58 , 59 (2006)
• [17] I.B. Afanas’eva, E.A. Ostrakhovitch, E.V. Mikhal’chik, G.A. Ibragimova, and L.G. Korkina, Biochem. Pharmacol., 61 , 677 (2001)
• [18] W.L. Bear and R.W. Teel, Anticancer Res., 20 , 3323 (2000)