The effect of stenosis rate and Reynolds number on local flow characteristics and plaque formation around the atherosclerotic stenosis

• Autorzy: Chen Xueping , Zhan Yiyi , Fu Yi , Lin Jiangguo , Ji Yanru , Zhao Chengbi , Fang Ying , Wu Jianhua

Identyfikatory

DOI

10.37190/ABB-01717-2020-04

• Języki publikacji: EN

Abstrakty

EN

Purpose: Atherosclerosis causes plaque to build-up in arteries. Effect of the specific local hemodynamic environment around an atherosclerotic plaque on the thrombosis formation does not remain quite clear but is believed to be crucial. The aim of this study is to uncover the flow effects on plaques formation. Methods: To study the mechanically regulated plaque formation, the flow fields in artery blood vessels with different stenosis rates at various Reynolds numbers were simulated numerically with the two-dimensional axisymmetric models, and the hemodynamic characteristics around the plaque were scaled with stenosis rate and Reynolds number. Results: The results showed that increases of both Reynolds number and stenosis rate facilitated the occurrence of flow separation phenomenon, extended recirculation zone, and upregulated the maximum normalized wall shear stress near the plaque throat section while downregulated the minimal normalized wall shear stress at the front shoulder of plaque, as it should be; in the atherosclerotic plaque leeside of the recirculation zone, an obvious catch bond region of wall shear stress might exist especially under low Reynolds number with stenosis rate smaller than 30%. This catch bond region in the plaque leeside might be responsible for the LBF (low blood flow)-enhanced formation of the atherosclerotic plaque. Conclusions: This work may provide a novel insight into understanding the biomechanical effects behind the formation and damage of atherosclerotic plaques and propose a new strategy for preventing atherosclerotic diseases.

Słowa kluczowe

EN

stenosis rate; Reynolds number; atherosclerotic plaque; hemodynamics

PL

stopień zwężenia; liczba Reynoldsa; blaszka miażdżycowa; hemodynamika

• Wydawca: Oficyna Wydawnicza Politechniki Wrocławskiej
• Czasopismo: Acta of Bioengineering and Biomechanics
• Rocznik: 2021
• Tom: Vol. 23, no. 1
• Strony: 135--147
• Opis fizyczny: Bibliogr. 30 poz., rys.

Twórcy

autor

Chen Xueping

• Institute of Biomechanics, School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China

autor

Zhan Yiyi

• Institute of Biomechanics, School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China
• Department of Electrical Engineering, School of Naval Architecture and Ocean Engineering, Guangzhou Maritime University, Guangzhou, China

autor

Fu Yi

• Collaborative Innovation Center for Biomedicines and School of Medical Instruments, Shanghai University of Medicine and Health Sciences, Shanghai, China

autor

Lin Jiangguo

• Institute of Biomechanics, School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China

autor

Ji Yanru

• Institute of Biomechanics, School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China

autor

Zhao Chengbi

• Department of Naval Architecture and Ocean Engineering, School of Civil Engineering and Transportation, South China University of Technology, Guangzhou, China

autor

Fang Ying

• Institute of Biomechanics, School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China

autor

Wu Jianhua

• Institute of Biomechanics, School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China

Bibliografia

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2024).