Design of a dedicated circular coil for Magnetic Resonance Spectroscopy studies in small phantoms and animal acquisition with a 3 Tesla Magnetic Resonance clinical scanner

• Autorzy: Giovannetti Giulio , Flori Alessandra , Marchi De Daniele , Montanaro Domenico , Frijia Francesca

Identyfikatory

DOI

10.2478/pjmpe-2020-0032

• Języki publikacji: EN

Abstrakty

EN

Introduction: Magnetic Resonance Spectroscopy (MRS) is a very powerful tool to explore the tissue components, by allowing a selective identification of molecules and molecular distribution mapping. Due to intrinsic Signal-to-Noise Ratio limitations (SNR), MRS in small phantoms and animals with a clinical scanner requires the design and development of dedicated radiofrequency (RF) coils, a task of fundamental importance. In this article, the authors describe the simulation, design, and application of a ¹H transmit/receive circular coil suitable for MRS studies in small phantoms and small animal models with a clinical 3T scanner. In particular, the circular coil could be an improvement in animal experiments for tumor studies in which the lesions are localized in specific areas. Material and methods: The magnetic field pattern was calculated using the Biot–Savart law and the inductance was evaluated with analytical calculations. Finally, the coil sensitivity was measured with the perturbing sphere method. Successively, a prototype of the coil was built and tested on the workbench and by the acquisition of MRS data. Results: In this work, we demonstrate the design trade-offs for successfully developing a dedicated coil for MRS experiments in small phantoms and animals with a clinical scanner. The coil designed in the study offers the potential for obtaining MRS data with a high SNR and good spectral resolution. Conclusions: The paper provides details of the design, modelling, and construction of a dedicated circular coil, which represents a low cost and easy to build answer for MRS experiments in small samples with a clinical scanner.

Słowa kluczowe

EN

magnetic field; inductance; signal-to-noise ratio; Magnetic Resonance Spectroscopy; radiofrequency coils

• Wydawca: Polskie Towarzystwo Fizyki Medycznej ; De Gruyter
• Czasopismo: Polish Journal of Medical Physics and Engineering
• Rocznik: 2020
• Tom: Vol. 26, Iss. 4
• Strony: 269--276
• Opis fizyczny: Bibliogr. 30 poz., rys., tab.

Twórcy

autor

Giovannetti Giulio

• Institute of Clinical Physiology, National Research Council (CNR), Pisa, Italy
• Fondazione CNR/Regione Toscana G. Monasterio, Pisa, Italy

autor

Flori Alessandra

• Fondazione CNR/Regione Toscana G. Monasterio, Pisa, Italy
• Institute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy

autor

Marchi De Daniele

• Fondazione CNR/Regione Toscana G. Monasterio, Pisa, Italy

autor

Montanaro Domenico

• Fondazione CNR/Regione Toscana G. Monasterio, Pisa, Italy

autor

Frijia Francesca

• Fondazione CNR/Regione Toscana G. Monasterio, Pisa, Italy

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2021).