Mathematic Simulating of Levofloxacin Release from Chitosan Nano/Microparticles

• Autorzy: Guan J. , Cheng P. , Huang S. , Li Z. , Wu J. , Gao P. , Wang X. , Zhang H.

Warianty tytułu

PL

Matematyczna symulacja lekarstwa levofloaxin w postaci nano- i mikroelementów

• Języki publikacji: EN

Abstrakty

EN

Chitosan based levofloxacin nano/microparticles were prepared by ionotropic gelatin and emulsion crosslinking technique. Their in vitro release profiles showed that microparticles had better sustaining delivery property than nanoparticles. The best fitting kinetics for nanoparticles and microparticles were First Order and Diffusion-Relaxation model respectively. The result suggests that levofloxacin delivery from nanoparticles was mainly controlled by diffusion process only, and that from microparticles was dominated by both diffusion and relaxation process.

PL

Mikro- i nanoelementy lekarstwa levofloaxin były wytwarzane techniką sieciowania emulsji. Dla lepszego dopasowania kinematyki opracowano model matematyczny. Stwierdzono że nanocząstki dostarczają materiał przez dyfuzję podczas gdy mikrocząstki wykorzystują też relaksację.

Słowa kluczowe

EN

chitosan; levofloxacin; nano/microparticles; mathematic simulating

PL

nanoelementy; mikroelementy; model matematyczny

• Wydawca: Wydawnictwo SIGMA-NOT
• Czasopismo: Przegląd Elektrotechniczny
• Rocznik: 2012
• Tom: R. 88, nr 7b
• Strony: 345--349
• Opis fizyczny: Bibliogr. 11 poz., tab., wykr.

Twórcy

autor

Guan J.

• Academy of Military Medical Sciences, No.106, WanDong Road, HeDong District, Tianjin, China, 300161

autor

Cheng P.

• Academy of Military Medical Sciences, No.106, WanDong Road, HeDong District, Tianjin, China, 300161

autor

Huang S.

• Academy of Military Medical Sciences, No.106, WanDong Road, HeDong District, Tianjin, China, 300161

autor

Li Z.

• Academy of Military Medical Sciences, No.106, WanDong Road, HeDong District, Tianjin, China, 300161

autor

Wu J.

• Academy of Military Medical Sciences, No.106, WanDong Road, HeDong District, Tianjin, China, 300161

autor

Gao P.

• Tianjin Institute of Medical and Pharmaceutical Sciences

autor

Wang X.

• Tianjin Institute of Medical and Pharmaceutical Sciences

autor

Zhang H.

• Tianjin Polytechnic University

Bibliografia

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• [2] Agnihotri S., Mallikarjuna N.N., Aminabhavi T.M., Recent advances on chitosan-based micro- and nanoparticles in drug delivery, Journal of Controlled Release, 100 (2004) , No. 1, 5-28
• [3] Wimer S.M., Schoonover L., Garrison M.W., Levofloxacin: a therapeutic review, Clinical Therapeutics, 20 (1998), No. 6, 1049-1070
• [4] Qian J.Q., Ma Y.Z., Preparation of levofloxacin-chitosan sustained-release microsphere, Journal of Zhejiang University of Technology, 32 (2004), No. 1, 20-24
• [5] Shen H.L., Wang Q., Qian F., Liu A.L., Li Y., Preparation and in vitro release of levofloxacin carboxymethyl chitosan sustained-releasing microsphere, Academic Journal of Second Military Medical University, 25 (2004), No. 5, 482-484
• [6] Li Y., Wang Q., Qian F., Shen H.. Preparation and controlled release of colon-targeted carboxymethyl chitosan microspheres containing levofloxacin: an in vivo study, Academic Journal of Second Military Medical University, 27 (2006), 517-520
• [7] Peng X.H., Zhang L., Kennedy J. F., Release behavior of microspheres from cross-linked N-methylated chitosan encapsulated ofloxacin, Carbohydrate Polymers, 65 (2006), No. 3, 288–295
• [8] Soppimath K.S., Aminabhavi T.M., Kulkarni A.R., Rudzinski W.E., Biodegradable polymeric nanoparticles as drug delivery devices, Journal of Controlled Release, 70 (2001), No. 1-2, 1-20
• [9] Guan J., Cheng P., Huang S.J., Wu J.M., Li Z.H., You X.D., Hao L.M., Guo Y., Li R.X., Zhang H., Optimized preparation of levofloxacin-loaded chitosan nanoparticles by ionotropic gelatin, Physics Procedia, 22 (2011), 163-169
• [10] Sahoo S., Sasmal A., Nanda R., Phani A.R., Nayak P.L., Synthesis of chitosan–polycaprolactone blend for control delivery of ofloxacin drug, Carbohydrate Polymers, 79 (2010), No. 1, 106–113
• [11] Papadimitriou S., Bikiaris D., Avgoustakis K., Karavas E., Georgarakis M., Preparation and in vivo characterization of chitosan nanoaprticles of dorzolamide and pramipexole, Carbohydrate Polymers, 73 (2008), No. 1, 44-54