Development of graphene-based biosensor for medical diagnostics

• Autorzy: Sobolewski P. , Penkala K. , Podolski J. , Mijowska E. , El Fray M.
• Konferencja: 24th Conference on Biomaterials in medicine and veterinary medicine : 9--12 October 2014, Rytro, Poland
• Języki publikacji: EN

Abstrakty

EN

The explosion of information provided by the “-omics,” (genomics, proteomics, etc.) has resulted in a pressing need to develop matching diagnostic technologies, so-called biosensors. Rapid, sensitive, selective, and cost-effective analysis of different biomolecules and microorganisms is crucial in clinical diagnosis and efficient treatment of patients. Further, there is a growing demand for decentralized laboratory methodologies that can be implemented in doctor’s office, emergency room or in the field for the analysis of such analytes as DNA, RNA, proteins, antibodies, bacteria, viruses, small compounds etc. Lab-on-a-chip platforms and miniaturized point-of-care devices based on biosensors fulfill these demands and are foreseen to revolutionize the future of medical diagnostics. Because of excellent electric and optical properties, graphene has recently found to be highly attractive in biosensing applications and may thrust new possibilities into the field of miniaturized medical diagnostic devices. The main objective of this project is to develop a multifunctional grapheme biosensor for effective electrochemical detection of specific DNA microbial targets in biological samples. Novel nanocomposites consisting of chitosan and nanoparticle-modified graphene will be combined with locked nucleic acid molecular beacons with the goal of producing “ink” for ultrasonic non-contact printing of electrical circuits. The developed technology will allow fabrication of low cost, highly sensitive biosensors for point-of-care diagnosis.

Słowa kluczowe

EN

biosensors; medical diagnosis; biomaterials

• Wydawca: Polish Society for Biomaterials in Cracow
• Czasopismo: Engineering of Biomaterials
• Rocznik: 2014
• Tom: Vol. 17, no. 128-129
• Strony: 83

Twórcy

autor

Sobolewski P.

• Polymer Institute, Department of Biomaterials and Microbiological Technologies, West Pomeranian University of Technology, Szczecin, Poland

autor

Penkala K.

• Faculty of Systems, Signals and Electronics Engineering, Department of Electrical Engineering, West Pomeranian University of Technology, Szczecin, Poland

autor

Podolski J.

• NZOZ Meditest Diagnostic Medicine, 14D Bronisławy Street, Szczecin, Poland

autor

Mijowska E.

• Division of Nanotechnology, Department of Chemical Engineering, West Pomeranian University of Technology, Szczecin, Poland

autor

El Fray M.

• Polymer Institute, Department of Biomaterials and Microbiological Technologies, West Pomeranian University of Technology, Szczecin, Poland