Determination of diosmetin-7-o-β-d-glucoside in rat plasma by UPLC–MS/MS

• Autorzy: Li Jianbo , Yu Zheng , Han Cheng , Wang Zhening , Hu Yujie , Wen Congcong , Lin Chongliang

Identyfikatory

DOI

10.1556/1326.2019.00720

• Języki publikacji: EN

Abstrakty

EN

In this study, we used UPLC–MS/MS to determine diosmetin-7-o-β-d-glucoside in rat plasma and investigated its pharmacokinetics in rats. Six rats were given diosmetin-7-o-β-d-glucoside (5 mg/kg) by intravenous (i.v.) administration. The blood (150 μL) was withdrawn from the caudal vein after administration. Diazepam was used as an internal standard (IS), and a one-step acetonitrile precipitation method was used to process the plasma samples. Chromatographic separation was achieved using a UPLC BEH C18 column using a mobile phase of acetonitrile–0.1% formic acid with gradient elution. Electrospray ionization (ESI) tandem mass spectrometry in multiple reaction monitoring (MRM) mode with positive ionization was applied, 463.1 → 301.0 for diosmetin-7-o-β-d-glucoside, m/z 285.1 → 193.0 for diazepam (IS). Intra-day and inter-day precision of diosmetin-7-o-β-d-glucoside in rat plasma were less than 14%. The method was successfully applied in the pharmacokinetics of diosmetin-7-o-β-d-glucoside in rats after intravenous administration. The t1/2 of diosmetin-7-o-β-d-glucoside is 1.4 ± 0.4 h, which indicates the quick elimination.

Słowa kluczowe

EN

diosmetin-7-o-β-d-glucoside; pharmacokinetics; rat

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2020
• Tom: Vol. 32, no. 4
• Strony: 264--268
• Opis fizyczny: Bibliogr. 33 poz., rys.

Twórcy

autor

Li Jianbo

• The Second Affiliated Hospital Zhejiang University School of Medicine Yuhang Campus, Hangzhou, China

autor

Yu Zheng

• Wenzhou Medical University, Wenzhou, China

autor

Han Cheng

• Wenzhou Medical University, Wenzhou, China

autor

Wang Zhening

• Wenzhou Medical University, Wenzhou, China

autor

Hu Yujie

• Wenzhou Medical University, Wenzhou, China

autor

Wen Congcong

• Wenzhou Medical University, Wenzhou, China

autor

Lin Chongliang

• The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

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Uwagi

PL

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2020).