PEG mediated eco-friendly one pot sunthesis of benzylamine coumarin derivatives using multicomponent reactant

• Autorzy: Viradiya D. J. , Kotadiya V. C , Khunt M. D. , Baria B. H. , Bhoya U. C.
• Języki publikacji: EN

Abstrakty

EN

A green resourceful, eco-friendly and facile protocol was developed for the synthesis of benzylamine coumarin derivatives by the reaction of 4-hydroxy coumarin, secondary amine and aromatic aldehyde in the presence of PEG400 as a solvent as well as catalyst at room temperature. A wide range of functional groups were tolerated in the developed protocol. The structures of all the synthesized compounds were confirmed by 1H NMR, IR, MASS and Elemental Analysis. The target molecules were obtained in good to excellent yield applying this method.

Słowa kluczowe

EN

one pot reaction; benzylamine coumarin derivative; green synthesis; PEG-400

• Wydawca: Przedsiębiorstwo Wydawnictw Naukowych "DARWIN"
• Czasopismo: International Letters of Chemistry, Physics and Astronomy
• Rocznik: 2014
• Tom: Vol. 11, iss. 2
• Strony: 177--184
• Opis fizyczny: Bibliogr. 18 poz., wykr., wz.

Twórcy

autor

Viradiya D. J.

• Deparment of Chemistry, Saurashtra University, Rajkot-360005, Gujrat, India.
• National Facility for Drug Discovery through New Chemical Entities Development and Instrumentation Support to Small Pharma Enterprises, Saurashtra University Rajkot - 360005, India

autor

Kotadiya V. C

• Deparment of Chemistry, Saurashtra University, Rajkot-360005, Gujrat, India.

autor

Khunt M. D.

• Deparment of Chemistry, Saurashtra University, Rajkot-360005, Gujrat, India.

autor

Baria B. H.

• Deparment of Chemistry, Saurashtra University, Rajkot-360005, Gujrat, India.
• National Facility for Drug Discovery through New Chemical Entities Development and Instrumentation Support to Small Pharma Enterprises, Saurashtra University Rajkot - 360005, India

autor

Bhoya U. C.

• Deparment of Chemistry, Saurashtra University, Rajkot-360005, Gujrat, India.

Bibliografia

• [1] A. Domling, Chem. Rev. 17 (2006) 106
• [2] J. Zhu Bienayme, H. Ed., Multicomponent Reactions, Wiley-VCH: Weinheim, 2005.
• [3] D. Raman, M. Yus, Chem. Int. Ed. 44 (2005) 1602.
• [4] M. Khunt, V. Kotadiya, D. Viradiya, B. Baria, U. Bhoya, International Letters of Chemistry, Physics and Astronomy 6 (2014) 61-68.
• [5] M. Kidwai, D. Bhatnagar, N. Mishra, V. Bansal, Catal. Commun 9 (2008) 2547.
• [6] D. Heldebrant, P. Jessop, J. Am. Chem. Soc. 125 (2003) 5600.
• [7] L. Heiss, H. Gais, Tetrahedron Lett. 36 (1995) 3833.
• [8] J. Xu, B. Liu, W. Wu, C. Qian, Q. Wu, X. Lin, J. Org. Chem. 71 (2006) 3991.
• [9] S. Hesse, G. Kirsch, Tetrahedron Lett. 43 (2002) 1213.
• [10] B. Lee, M. Clothier, F. Dutton, G. Conder, S. Johnson, Bioorg. Med. Chem. Lett. 8 (1998) 3317.
• [11] J. Jung, Y. Jung, O. Park, Synth. Commun. 31 (2001) 1195.
• [12] G. Melagraki, A. Afantitis, O. Igglessi-Markopoulou, A. Detsi, M. Koufaki, C. Kontogiorgis, D. Hadjipavlou-Litina, Eur. J. Med. Chem. 44 (2009) 3020.
• [13] J. Jung, J. Lee, S. Oh, J. Lee, O. Park, Bioorg. Med. Chem. Lett. 14 (2004) 5527.
• [14] E. Ghabraiea, M. Bararjaniana, S. Balalaie, F. Rominger, H. Bijanzadeh, Helv. Chim. Acta 94 (2011) 1440.
• [15] N. Robertson, P. Link J.Am. Chem. Soc. 75 (1953) 1883.
• [16] A. Kumar, M. Gupta, M. Kumar, Tetrahedron Lett. 52 (2011) 4521.
• [17] N. Vukovic, S. Sukdolak, S. Solujic, N. Niciforovic, Arch. Pharmacol. Res. 33 (2010) 5.
• [18] G. Zhao, T. Jiang, H. Gao, B. Han, J. Huang, D. Sun, Green Chem. 6 (2004) 75.