Simultaneous quantification of five lignans from Schisandra chinensis in various tissues of rats

• Autorzy: Su Lian-Lin , Cheng Xue , Ding Xi-Yan , Mao Chun-Qin , Lu Tu-Lin , Hao Min , Li B.-W. , Qin Sirui

Identyfikatory

DOI

10.1556/1326.2018.00387

• Języki publikacji: EN

Abstrakty

EN

In this research study, a rapid, sensitive, and specific high-performance liquid chromatography–electrospray ionization–tandem mass spectrometry (HPLC–ESI–MS/MS) method was established and validated, in regard to the simultaneous quantification of five sedative and hypnotic lignans (schisandrin, schisandrol B, schisantherin A, deoxyschisandrin, and schisandrin B) in various tissues of rats (including heart, liver, spleen, lung, and kidney). The purpose of the study was to clarify the tissue distribution of the total lignans extract of Schisandra chinensis (SC). Then, the analytes were separated on a MERCK Purospher STAR LP C₁₈ column (250 mm × 4.6 mm, 5 μm), with a mobile phase consisting of 0.05% (v/v) formic acid acetonitrile, and 0.05% (v/v) formic acid water, and a flow rate of 1 mL/min. All of the calibration curves of the five components showed good linearity (r > 0.9950), with ranges of 4.8 to 1920 ng/mL for analytes. The intra-day and inter-day precisions (relative standard deviation [RSD] %) were within 13.76% for all of the analytes. The average recoveries of the five analytes were greater than 85.23%, and the mean value of the matrix effect ranged from 82.3% to 93.4%. The five analytes were confirmed to be stable during the storage, preparation, and analytic procedures. The major target tissues of the total lignans extract of the SC in the rats were the livers and kidneys.

Słowa kluczowe

EN

Schisandra chinensis; lignans; tissue distribution; HPLC-ESI-MS/MS

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2019
• Tom: Vol. 31, no. 2
• Strony: 113--119
• Opis fizyczny: Bibliogr. 34 poz., rys., tab.

Twórcy

autor

Su Lian-Lin

• College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China

autor

Cheng Xue

• College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China

autor

Ding Xi-Yan

• College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China

autor

Mao Chun-Qin

• College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
• Jiangsu Key Laboratory of Chinese Medicine Processing, Nanjing University of Chinese Medicine, 210023 Nanjing, China

autor

Lu Tu-Lin

• College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
• Jiangsu Key Laboratory of Chinese Medicine Processing, Nanjing University of Chinese Medicine, 210023 Nanjing, China

autor

Hao Min

• College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China

autor

Li B.-W.

• College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China

autor

Qin Sirui

• Wuhan University, Wuhan 430072, China

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Uwagi

PL

Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2019).