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Abstrakty
In this research study, a rapid, sensitive, and specific high-performance liquid chromatography–electrospray ionization–tandem mass spectrometry (HPLC–ESI–MS/MS) method was established and validated, in regard to the simultaneous quantification of five sedative and hypnotic lignans (schisandrin, schisandrol B, schisantherin A, deoxyschisandrin, and schisandrin B) in various tissues of rats (including heart, liver, spleen, lung, and kidney). The purpose of the study was to clarify the tissue distribution of the total lignans extract of Schisandra chinensis (SC). Then, the analytes were separated on a MERCK Purospher STAR LP C18 column (250 mm × 4.6 mm, 5 μm), with a mobile phase consisting of 0.05% (v/v) formic acid acetonitrile, and 0.05% (v/v) formic acid water, and a flow rate of 1 mL/min. All of the calibration curves of the five components showed good linearity (r > 0.9950), with ranges of 4.8 to 1920 ng/mL for analytes. The intra-day and inter-day precisions (relative standard deviation [RSD] %) were within 13.76% for all of the analytes. The average recoveries of the five analytes were greater than 85.23%, and the mean value of the matrix effect ranged from 82.3% to 93.4%. The five analytes were confirmed to be stable during the storage, preparation, and analytic procedures. The major target tissues of the total lignans extract of the SC in the rats were the livers and kidneys.
Słowa kluczowe
Czasopismo
Rocznik
Tom
Strony
113--119
Opis fizyczny
Bibliogr. 34 poz., rys., tab.
Twórcy
autor
- College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
autor
- College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
autor
- College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
autor
- College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
- Jiangsu Key Laboratory of Chinese Medicine Processing, Nanjing University of Chinese Medicine, 210023 Nanjing, China
autor
- College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
- Jiangsu Key Laboratory of Chinese Medicine Processing, Nanjing University of Chinese Medicine, 210023 Nanjing, China
autor
- College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
autor
- College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
autor
- Wuhan University, Wuhan 430072, China
Bibliografia
- [1] State Pharmacopoeia Commission. Ch. P[S] China Medical Science and Technology Press: Beijing, 2010, 61.
- [2] Caichompoo, W.; Zhang, Q. Y.; Hou, T. T.; Gao, H. J.; Qin, L. P.; Zhou, X. J. Phytother. Res. Ptr. 2009, 23, 289–292.
- [3] Huang, X.; Song, F.; Liu, Z.; Liu, S. Anal. Chim. Acta 2008, 615, 124–135.
- [4] Opletal, L.; Sovová, H.; Bártlová, M. J. Chromatogr. B 2004, 812, 357–371.
- [5] Chen, M.; Kilgore, N.; Lee, K. H.; Chen, D. F. J. Nat. Prod. 2006, 69, 1697–1701.
- [6] Jiang, S. L.; Zhang, Y. Y.; Chen, D. F. J. Shanghai Med. 2005, 32, 467–471.
- [7] Kuo, Y. H.; Kuo, L. M.; Chen, C. F. J. Org. Chem. 1997, 28, 3242.
- [8] Liang, Y.; Hao, H. P.; Xie, L.; Kang, A.; Xie, T.; Zheng, X.; Dai, C.; Hao, K.; Sheng, L. S.; Wang, G. J. Drug Metab. Dispos. 2010, 38, 1747–1759.
- [9] Lou, Z. Y.; Zhang, H.; Gong, C. G.; Zhu, Z. Y.; Zhao, L.; Xu, Y. J.; Wang, B.; Zhang, G. Q. Rapid Commun. Mass Spectrom. 2009, 23, 831–842.
- [10] Mao, S. L.; Zhang, H.; Lv, L.; Zhu, Z. Y.; Zhao, L.; Zhang, G. Q.; Chai, Y. F. Biomed. Chromatogr. 2011, 25, 808–815.
- [11] Tang, J. L.; Shao, B.; Liu, Y.; Liu, H. M.; Ji, H. Y.; Zhu, D. L.; Wu, L. H. Biomed. Chromatogr. 2010, 24, 675–681.
- [12] Wang, B. L.; Hu, J. P.; Tan, W.; Sheng, L.; Chen, H.; Li, Y. J. Chromatogr. B 2008, 865, 114–120.
- [13] Jiang, Y. M.; Fan, X. M.; Wang, Y.; Tan, H. S.; Chen, P.; Zeng, H.; Huang, M.; Bi, H. C. Chem.-Biol. Interact. 2015, 231, 83–89.
- [14] Xie, Y.; Hao, H. P.; Wang, H.; Guo, C.; Kang, A.; Wang, G. J. J. Ethnopharmacol. 2014, 155, 213–221.
- [15] Wu, X. Y.; Zhou, Y.; Yin, F. Z.; Dai, G. L.; Li, L.; Xu, B.; Ji, D.; Sun, Y.; Mao, C. Q.; Lu, T. L. Biomed. Chromatogr. 2014, 28, 1075–1083.
- [16] Guo, W. J.; Shao, Q.; Zhang, Y. F.; Fan, X. H. Zhejiang Daxue Xuebao, Yixueban. 2012, 41, 6–12.
- [17] Zhu, H. Y.; Zhang, X. R.; Guan, J.; Cui, B. J.; Zhao, L. S.; Zhao, X. J. Pharm. Biomed. Anal. 2013, 78, 136–140.
- [18] Qin, X. L.; Bi, H. C.; Wang, C. X.; Li, J. L.; Wang, X. D.; Liu, L. S.; Chen, X.; Huang, M. Biomed. Chromatogr. 2010, 24, 399–405.
- [19] Lu, T. L.; Wu, X. Y.; Song, Y.; Chen, H.; Xu, B.; Zhou, Y.; Huang, Z. J.; Sun, Y.; Mao, C. Q. Acupunct. Med. 2013, 31, 207–213.
- [20] Li, H. L.; Ji, D.; Mao, C. Q.; Tao, Y.; Lu, T. L.; Liu, H. Z. Lat. Am. J. Pharm. 2014, 33, 315–25.
- [21] Chun, J. N.; Cho, M.; So, I.; Jeon, J. H. Fitoterapia 2014, 97, 224–233.
- [22] Jiang, Y. M.; Fan, X. M.; Wang, Y.; Tan, H. S.; Chen, P.; Zeng, H.; Huang, M.; Bi, H. C. Chem.-Biol. Interact. 2015, 231, 83–89.
- [23] Zhai, J. X.; Zhang, F.; Gao, S. H.; Chen, L.; Feng, G.; Yin, J.; Chen, W. S. J. Ethnopharmacol. 2017, 210, 223–231.
- [24] Lu, T. L.; Hu, J. Y.; Mao, C. Q.; Wu, Y.; Yin, F. Z.; Cai, B. C. J. Food Drug Anal. 2012, 20, 561–568.
- [25] Ceslová, L.; Holcapek, M.; Nobilis, M. J. Pharm. Biomed. Anal. 2014, 88, 221–224.
- [26] Yang, J. M.; Siu-po, P. I. P.; Yeung, H.-k. J.; Che, C. T. Acta Pharm. Sin. B 2011, 1, 46–55.
- [27] Lafaille, F.; Solassol, I.; Enjalbal, C.; Bertrand, B.; Doulain, P. E.; Vappiani, J.; Bonnet, P. A.; Carine, D. M.; Bressolle, F. J. Pharm. Biomed. Anal. 2014, 88, 429–440.
- [28] Chambers, E. E.; Woodcock, M. J.; Wheaton, J. P.; Pekol, T. M.; Diehl, D. M. J. Pharm. Biomed. Anal. 2014, 88, 660–665.
- [29] Seip, K. F.; Bjerknes, K. C.; Johansen, H. T.; Nielsen, E. W.; Landrø, L.; Reubsaet, L. J. Chromatogr. B 2014, 947–948, 139–144.
- [30] Wei, B. B; Li, Q.; Su, D.; Fan, R. H.; Zhao, L. S.; Geng, L. L.; He, B. S.; Chen, X. H.; Jia, Y.; Bi, K. S. J. Pharm. Biomed. Anal. 2013, 77, 120–127.
- [31] Guo, W.; Shi, X. W.; Wang, W.; Xiong, C.; Li, J. X. J. Chromatogr. B 2014, 947–948, 151–155.
- [32] Zhang, J.; Zhang, M.; Fu, S.; Li, T.; Wang, S.; Zhao, M. M.; Ding, W. J.; Wang, C. Y.; Wang, Q. J. Chromatogr. B 2014, 945–946, 185–192.
- [33] Wu, H. F.; Guo, J.; Chen, S. L.; Liu c, X.; Zhou, Y.; Zhang, X. P.; Xu, X. D. J. Pharm. Biomed. Anal. 2013, 72, 267–291.
- [34] Liang, J.; Xu, F.; Zhang, Y. z.; Huang, S.; Zang, X. Y.; Zhao, X.; Zhang, L.; Shang, M. Y.; Yang, D. H.; Wang, X.; Cai, S. Q. J. Pharm. Biomed. Anal. 2013, 83, 108–121.
Uwagi
PL
Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2019).
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-8cf74dee-110b-4f54-a397-7f2c24ef0e28