Use of validated stability-indicating chromatographic methods for quantitative analysis of idrocilamide in a pharmaceutical formulation

• Autorzy: Salem M. Y , Din Salama N. N , Abd El-Halim L. M , El-Sayed Abdel Fattah L
• Języki publikacji: EN

Abstrakty

EN

Two sensitive and selective chromatographic methods have been developed and validated for analysis of idrocilamide in the presence of its degradation products. Forced degradation studies were performed using HCl, NaOH, and 3% H₂O₂. The first method is based on thin-layer chromatographic separation of the intact drug from its degradation products, followed by densitometric measurement. The second method is based on isocratic reversed phase high-performance liquid chromatographic separation of the drug from its degradation products on a C₁₈ column. The HPLC method was used to investigate the kinetics of alkaline degradation of the drug at different temperatures.

Słowa kluczowe

EN

idrocilamide; TLC-densitometry; HPLC; stability studies; kinetics

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2010
• Tom: Vol. 22, no. 4
• Strony: 569--579
• Opis fizyczny: Bibliogr. 12 poz., rys., tab.

Twórcy

autor

Salem M. Y

• Cairo University Analytical Chemistry Department, Faculty of Pharmacy Cairo Egypt

autor

Din Salama N. N

• National Organization for Drug Control and Research (NODCAR) 6 Abu Hazem Street, Pyramids P.O. Box 29 Cairo Egypt

autor

Abd El-Halim L. M

• National Organization for Drug Control and Research (NODCAR) 6 Abu Hazem Street, Pyramids P.O. Box 29 Cairo Egypt

autor

El-Sayed Abdel Fattah L

• Cairo University Analytical Chemistry Department, Faculty of Pharmacy Cairo Egypt

Bibliografia

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