Symulacje numeryczne procesu desorpcji i dyfuzji leku w materiale z nanowłókien

Nakielski, P.

Artykuł - szczegóły

Tytuł artykułu

Symulacje numeryczne procesu desorpcji i dyfuzji leku w materiale z nanowłókien

Autorzy

Nakielski P.

Identyfikatory

Warianty tytułu

Numerical modeling of desorption-diffusion process of drug release system based on nanofibrous matrix

Języki publikacji

Abstrakty

W pracy przedstawiono symulacje metodą elementów skończonych procesu desorpcji leku z powierzchni nanowłókien oraz dyfuzji wewnątrz porowatego materiału w zależności od wzajemnej konfiguracji włókien. Zbadano uwalnianie leku w różnych typach ułożenia włókien w materiale od idealnie ukierunkowanych po włókna ułożone nieregularnie. Dodatkowo przeanalizowano wpływ lokalnego zagęszczenia włókien i porowatości materiału na proces dyfuzji w macie. Przedstawiony model porównano z wynikiem eksperymentalnym uwalniania Rodaminy B z elektroprzędzonych nanowłókien oraz rozwiązaniem analitycznym dyfuzji z płaskiej płyty z homogenicznie rozmieszczonym lekiem. Celem przeprowadzonych obliczeń jest znalezienie kluczowych parametrów materiału, stosowanego jako system uwalniania leków w zapobieganiu neurodegeneracji po operacjach neurochirurgicznych.

In the paper the finite element simulations of desorption of drug from the surface of the nanofibers and diffusion inside the porous material, depending on the configuration of the fibers are presented. Drug release was examined in various types of the fibers arrangement from perfectly oriented to irregularly arranged. In addition, the impact of the local compaction of fibers and porosity of mats on the process of diffusion in the material was analyzed. The presented model was compared with the experimental result of the release of Rhodamine B from electrospun nanofibers and with the analytical solution of diffusion from a flat plate with a homogeneously distributed drug. The aim of the work is to find the key parameters of the material, used as a drug delivery system for the prevention of neurodegeneration after neurosurgical procedures.

Słowa kluczowe

desorpcja dyfuzja FRAP nanowłókna uwalnianie leków

desorption drug release diffusion FRAP nanofibers

Wydawca

Polskie Towarzystwo Mechaniki Teoretycznej i Stosowanej. Oddział Gliwice

Czasopismo

Modelowanie Inżynierskie

Rocznik

2013

Tom

T. 17, nr 48

Strony

99--111

Opis fizyczny

Bibliogr. 37 poz.

Twórcy

autor

Nakielski P.

pnakiel@ippt.pan.pl

Zakład Mechaniki i Fizyki Płynów, Instytut Podstawowych Problemów Techniki PAN

Bibliografia

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Typ dokumentu

Bibliografia

Identyfikator YADDA

bwmeta1.element.baztech-8c274465-6b16-461c-9fce-dd7655041636