Fractional order based velocity control system for a nanorobot in non-Newtonian fluids

• Autorzy: Muresan C. I. , Birs I. R. , Folea S. , Ionescu C.

Identyfikatory

DOI

10.24425/bpas.2018.125946

• Języki publikacji: EN

Abstrakty

EN

Customized patient drug delivery overcomes classic medicine setbacks such as side effects, improper drug absorption or slow action. Nanorobots can be successfully used for targeted patient-specific drug administration, but they must be reliable in the entire circulatory system environment. This paper analyzes the possibility of fractional order control applied to the nanomedicine field. The parameters of a fractional order proportional integral controller are determined with the purpose of controlling the velocity of the nanorobot in non-Newtonian fluids envisioning the blood flow in the circulatory system.

Słowa kluczowe

EN

non-Newtonian fluids; drag force; velocity control; fractional calculus

PL

płyny nienewtonowskie; kontrola prędkości; rachunek ułamkowy

• Wydawca: Polska Akademia Nauk, Wydział IV Nauk Technicznych
• Czasopismo: Bulletin of the Polish Academy of Sciences. Technical Sciences
• Rocznik: 2018
• Tom: Vol. 66, nr 6
• Strony: 991--997
• Opis fizyczny: Bibliogr. 18 poz., rys., wykr.

Twórcy

autor

Muresan C. I.

• Technical University of Cluj-Napoca, Romania

autor

Birs I. R.

• Technical University of Cluj-Napoca, Romania

autor

Folea S.

• Technical University of Cluj-Napoca, Romania

autor

Ionescu C.

• Technical University of Cluj-Napoca, Romania
• Ghent University, Belgium

Bibliografia

• [1] C. Ionescu, P. Segers, and R. De Keyser, “Mechanical properties of the respiratory system derived from morphologic insight”, IEEE Trans. Biomed. Eng. 56, 949‒959 (2009).
• [2] C. Ionescu and R. De Keyser, “Relations between fractional order model parameters and lung pathology in chronic obstructive pulmonary disease”, IEEE Trans. Biomed. Eng. 56, 978‒987 (2009).
• [3] F. Mainardi, “Fractional calculus and waves in linear viscoelasticity: An introduction to mathematical models”, Imperial College Press, London, 2010.
• [4] C.A. Monje, Y. Chen, B.M. Vinagre, D. Xue, and V. Feliu, “Fractional-order systems and controls: Fundamentals and applications”, Springer, London, 2010.
• [5] C.I. Pop, C.M. Ionescu, R. De Keyser, E.H. Dulf, and E.-H, “Robustness evaluation of Fractional Order Control for Varying Time Delay Processes”, Signal, Image and Video Processing. 6, 453‒461 (2012).
• [6] A. Oustaloup, “La commande CRONE: commande robust d’ordre non entiere”, Hermes, Paris, France, 1991.
• [7] C.A. Monje, B. Vinagre, Y. Chen, and V. Feliu, “On fractional PIλ controllers: some tuning rules for robustness to plant uncertainties”, Nonlinear Dyn. 38, 369–381 (2004).
• [8] C.M. Ionescu, “A memory-based model for blood viscozity”, Commun. Nonlinear Sci. Numer. Simul. 45, 29‒34 (2017).
• [9] P. Perdikaris and G.E. Karniadakis, “Fractional-order viscoelasticity in one-dimensional blood flow models”. Annals of Biomedical Engineering 42 (5), 1012‒1023 (2012).
• [10] Y. Liu, H. Miyoshi, and M. Nakamura, “Nanomedicine for drug delivery and imaging: a promising avenue for cancer therapy and diagnosis using targeted functional nanoparticles”. Int. J. Cancer 120, 2527–2537 (2007).
• [11] V. Jain, S. Jain, and S.C. Mahajan, “Nanomedicines based drug delivery systems for anti-cancer targeting and treatment”. Curr Drug Deliv. 12(2), 177–91 (2015).
• [12] P. Debbage, “Targeted drugs and nanomedicine: present and future”, CurrPharm Des 2009; 15:153–72.
• [13] V.K. Khanna, “Targeted delivery of nanomedicines”. ISRN Pharmacology, 2012, 2012, 1–9.
• [14] J.A.T. Machado, A. Galhano, and J.J. Trujillo, “On development of fractional calculus during the last fifty years.” Scientometrics 98, 577‒582 (2013).
• [15] W. Jifeng and L. Yuankai, “Frequency domain anal- ysis and applications for fractional-order control systems”, Journal of Physics: Conference Series 13 (1), 2005.
• [16] I. Birs, C. Muresan, S. Folea, and O. Prodan, “An Experimental Nanomedical Platform for Controller Validation on Targeted Drug Delivery”, Australian and New Zealand Control Conference (ANZCC), 17‒20 December 2017, Gold Coast, Australia. [17] S.N. Doost, L. Zhong, B. Su, and Y.S. Morsi, “The numerical analysis of non-Newtonian blood flow in human patient-specific left ventricle”, Comput. Methods Programs Biomed. 127, 232‒247 (2016).
• [18] M. Sanak, B. Jakiela, and W. Wegrzyn, “Assessment of hemocompatibility of materials with arterial blood ow by platelet functional”, Bull. Pol. Ac:. Tech. 58(2), 317‒322 (2010).

Uwagi

PL

Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2019).