Biological Dressings Based on Natural Polymers

• Autorzy: Kucharska M. , Brzoza-Malczewska K. , Wiśniewska-Wrona M. , Pałys B. , Struszczyk M. H. , Cichecka M. , Wilbik-Hałgas B. , Karuga-Kuźniewska E. , Paluch D. , Rybak Z.

Identyfikatory

DOI

10.5604/12303666.1221753

Warianty tytułu

PL

Opatrunki biologiczne oparte na polimerach naturalnych

• Języki publikacji: EN

Abstrakty

EN

The article presents a method for producing a IV generation hemostatic dressing in the form of powder consisted of fibrous, which ensures a high level of security in application. The dressing material was developed on the basis of natural polymers of the polysaccharide group such as chitosan and calcium sodium alginate in the form of micro- and nanofibrids. The dressing structure, utility properties and biocompatibility (cytotoxicity, irritation and sensitization) were studied.

PL

W artykule przedstawiono metodę wytwarzania hemostatycznego opatrunku IV generacji, który gwarantuje wysoki stopień bezpieczeństwa przy aplikacji. Opatrunek posiada formę proszku fibrydowego. Do opracowania materiału opatrunkowego wykorzystane zostały polimery naturalne z grupy polisacharydów takie jak chitozan i alginian sodowo-wapniowy. Opatrunek został poddany badaniom strukturalnym, właściwościom użytkowym oraz ocenie biozgodności (cytotoksyczność, właściwości drażniące i uczulające).

Słowa kluczowe

EN

wound dressing; polysaccharides; microfibrids; nanofibrids; biocompatibility

PL

opatrunek; polisacharydy; proszek fibrydowy; biozgodność

• Wydawca: Sieć Badawcza Łukasiewicz - Łódzki Instytut Technologiczny
• Czasopismo: Fibres & Textiles in Eastern Europe
• Rocznik: 2016
• Tom: Vol. 24, no. 6 (120)
• Strony: 170--174
• Opis fizyczny: Bibliogr. 24 poz., rys., tab.

Twórcy

autor

Kucharska M.

• Institute of Biopolymers and Chemical Fibres, ul. M. Skłodowskiej19/27, 90-570 Łódź, Poland

autor

Brzoza-Malczewska K.

• Institute of Biopolymers and Chemical Fibres, ul. M. Skłodowskiej19/27, 90-570 Łódź, Poland

autor

Wiśniewska-Wrona M.

• Institute of Biopolymers and Chemical Fibres, ul. M. Skłodowskiej19/27, 90-570 Łódź, Poland

autor

Pałys B.

• Institute of Biopolymers and Chemical Fibres, ul. M. Skłodowskiej19/27, 90-570 Łódź, Poland

autor

Struszczyk M. H.

• Institute of Security Technology MORATEX, ul. M. Skłodowskiej-Curie 3, 90-505 Łódź, Poland

autor

Cichecka M.

• Institute of Security Technology MORATEX, ul. M. Skłodowskiej-Curie 3, 90-505 Łódź, Poland

autor

Wilbik-Hałgas B.

• Institute of Security Technology MORATEX, ul. M. Skłodowskiej-Curie 3, 90-505 Łódź, Poland

autor

Karuga-Kuźniewska E.

• Department of Experimental Surgery and Biomaterials Examination Research, Medical University of Wroclaw, Wroclaw, Poland

autor

Paluch D.

• Department of Experimental Surgery and Biomaterials Examination Research, Medical University of Wroclaw, Wroclaw, Poland

autor

Rybak Z.

• Department of Experimental Surgery and Biomaterials Examination Research, Medical University of Wroclaw, Wroclaw, Poland

Bibliografia

• 1. Committee on fluid resuscitation for combat casualties. Fluid resuscitation: state of the science for treating combat casualties and civilian injuries. Report of the Institute of Medicine. National Academy Press; Washington, DC, 1999, pp 1–7.
• 2. Wedmore JG, McManus A E, Pusateri J B. Holcomb: A special report on the chitosan based hemostatic dressing: experience in current combat operations. J Trauma 2006;60(3): 655-8.
• 3. Evans J A, Wessem K J P, McDougall D, Lee K A, Lyons T, Balogh Z J. Epidemiology of Traumatic Deaths: Comprehensive Population-Based Assessment. World Journal of Surgery 2009; 34, 1: 158-163.
• 4. Bellamy RF. The cause of death in conventional land warfare: implications for combat casualty care research. Milit Med 1984; 149: 55–62.
• 5. Alam H B, Burris D, DaCorta J A and Rhee P. Hemorrhage Control in the Battlefield: Role of New Hemostatic Agents. Military Medicine 2005; 170, 1: 63 - 69.
• 6. Samudrala S. Topical Hemostatic Agents in Surgery: A Surgeon’s Perspective. AORN 2008; 88, 3: S2-S11.
• 7. Struszczyk M H and Olejnik M. Obecne i przyszłe zapotrzebowanie rynku na włókiennicze wyroby medyczne. TechniczneWyrobyWłókiennicze 2010; 19-25.
• 8. The EU market for wound care and wound closure products, CBI Market Survey, 2009, http://www.icci.com.pk/data/downloads/10/1169838317_1.pdf [2012-03-02].
• 9. US Markets for Wound Management Products, Medtech Insight, RP-181303.
• 10. All Change in the Advanced Wound CareMarket 2009. A complete guide to this dynamic market sector, Espicom Business Intelligence Ltd, May 2009.
• 11. Budynek M and Nowacki C. Wiedza o opatrunkach, Łódź, 1999.
• 12. Willi P and Sharma Ch P. Chitosan and Alginate Wound Dressings: A Short Review. Trends Biomater. Artif. Organs 2004; 18(1): pp 18-23.
• 13. Dai T, Tanaka M and Huang YY R. Hamblin Chitosan preparations for wounds and burns: antimicrobial and woundhealing effects. Expert Rev Anti Infect Ther 2011; 9(7): 857–79.
• 14. Stephen-Haynes J, Gibson E, Greenwood M. Chitosan: a natural solution for wound healing. JCN 2014, 28, 1: 50-53.
• 15. Anitha A S. Sowmya P T, Sudheesh Kumar S, Deepthi K P, Chennazhi H, Ehrlich M, Tsurkan R. Jayakumar Chitin and chitosan in selected biomedical applications.Progress in Polymer Science2014; 39, 9: 1644–1667.
• 16. Muzzarelli R A A. Chitins and chitosans for the repair of wounded skin, nerve, cartilage and bone. Carbohydrate Polymers 2009; 76: 167–182.
• 17. http://www.trends-in-medicine.com/Oct2003/Closure103p.pdf, Hemorrhage Control in the Battlefield: Role of New Hemostatic Agents. MILITARY MEDICINE 2005; 170, 1:63.
• 18. Fischer T H, Connolly R, Thatte H S, Schwaitzberg S S. Comparison of Structural and Hemostatic Properties of the poly-N-acetylglucosamineSyvek Patch with Products Containing Chitosan. Microscopy Research and Technique 2004; 63(3): 168-174.
• 19. Millner R W J, Lockhart A S, Alexiou Ch. A New hemostatic agent:initial Life-saving experience with Celox (chitosan) In cardiothoracic surgery. Ann. Thorac. Surg. 2009; 87, 13-14.
• 20. Gegel B, Burgert J, Cooley B, et. All. The effects of bleed-arrest, Celox, and trauma-dex on haemorrhage control in a porcine model. J. of Surgical Research 2010; 164: 125-129.
• 21. http://kopalniawiedzy.pl/opatrunek-chitosan-rana-krew-wypadek-ofiara-zolnierz- 9127.html
• 22. A method for producing fibrids containing chitosan. PL 214 380, 2008.
• 23. Kucharska M, Wiśniewska-Wrona M, Brzoza-Malczewska K, Struszczyk M H, Cichecka M, Wilbik-Hałgas B, Rybak Z, Szymonowicz M, Paluch D, Guzińska K, Kaźmierczak D. Haemostatic, resorbable dressing of natural polymers- HEMOGUARD, In: Progress on Chemistry and Application of Chitin and Its Derivatives, edited by M. Jaworska, vol. XX, Polish Chitin Society, 2015, p.130, DOI: 10.15259/PCACD.20.28.
• 24. Szymonowicz M, Kucharska M, Wiśniewska-Wrona M, Rybak Z. Evaluation of the hemostatic properties of the resorbable wound dressings in contact with blood in vitro. Acta of Bioengineering and Biomechanics DOI 10.5277/abb, ISSN: 1509-409X

Uwagi

Opracowanie ze środków MNiSW w ramach umowy 812/P-DUN/2016 na działalność upowszechniającą naukę (zadania 2017).