Physicochemical characterization of ionically cross-linked hydrogel matrices with incorporated fananserin derivative

• Autorzy: Komaniecka Sandra , Odziomek Kacper , Zaręba Przemysław , Bialik-Wąs Katarzyna

Identyfikatory

DOI

10.34821/eng.biomat.173.2025.05

• Języki publikacji: EN

Abstrakty

EN

The fananserin derivative, such as 1-{6-[4-(2-fluorophenyl)piperazin-1-yl]hexyl}-benzo[cd]indol-2(1H)-one (compound FL-4), represents an interesting biologically active substance that can be incorporated into polymeric carriers. Due to its highly hydrophobic nature and poor solubility in conventional solvents, FL-4 was incorporated into a delivery system to improve its solubility, stability, and bioavailability. Based on preliminary studies and DLS analysis, an optimal concentration of FL-4 (10 mg) was selected, ensuring system stability. This system was incorporated into polymer matrices, resulting in two hydrogel delivery systems: M10-J, containing FL-4, and M10-T-J, which combines a thermosensitive nanocarrier with FL-4, both ionically cross-linked. The systems were evaluated for their physicochemical properties, including swelling abilities, degradation, chemical structure (based on FTIR spectra analysis), morphology (based on SEM images), and substance release profiles. The M10-T-J samples showed a swelling ratio of 0.27 g/g in PBS and 0.35 g/g in water, while M10-J exhibited 0.16 g/g in PBS and 0.2 g/g in water. The pH and conductivity analysis suggested a faster degradation process for M10-T-J hydrogel compared to M10-J. FT-IR analysis confirmed the chemical structure of the materials, revealing significant changes in M10-T-J samples, indicating interactions between FL-4 and CaCl₂ used during cross-linking. SEM and EDS analysis showed a uniform distribution of FL-4 on the matrix surface in both hydrogel variants, with the addition of the thermosensitive nanocarrier not significantly affecting the morphology. The M10-J hydrogel exhibited rapid release of FL-4 within the first 4 h, while M10-T-J showed limited release.

Słowa kluczowe

EN

drug delivery system; fananserin derivative; hydrogel; thermoresponsive nanocarrier; transdermal systems

PL

system dostarczania leków; pochodna fananseryny; hydrożel; nanonośnik termoreaktywny; systemy transdermalne

• Wydawca: Polish Society for Biomaterials in Cracow
• Czasopismo: Engineering of Biomaterials
• Rocznik: 2025
• Tom: vol. 28, no. 173
• Strony: art. no. 5
• Opis fizyczny: Bibliogr. 38 poz., tab., wykr., zdj.

Twórcy

autor

Komaniecka Sandra

• Cracow University of Technology, Faculty of Chemical Engineering and Technology, 24 Warszawska St., 31-155 Cracow, Poland

autor

Odziomek Kacper

• Cracow University of Technology, Faculty of Chemical Engineering and Technology, 24 Warszawska St., 31-155 Cracow, Poland

autor

Zaręba Przemysław

• Cracow University of Technology, Faculty of Chemical Engineering and Technology, Department of Chemical Technology and Environmental Analytics, 24 Warszawska St., 31-155 Cracow, Poland

autor

Bialik-Wąs Katarzyna

• Cracow University of Technology, Faculty of Chemical Engineering and Technology, Department of Chemistry and Technology of Polymers, 24 Warszawska St., 31-155 Cracow, Poland

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa nr POPUL/SP/0154/2024/02 w ramach programu "Społeczna odpowiedzialność nauki II" - moduł: Popularyzacja nauki i promocja sportu (2025).