Determination of the lipophilicity of new azaphenothiazines by reversed-phase thin-layer chromatography

• Autorzy: Zięba A. , Prus W.
• Języki publikacji: EN

Abstrakty

EN

The lipophilicity R M0 and log P TLC of thirteen novel, potentially biologically active, 12 H -quino[3,4- b] [1,4] benzothiazinium salts have been determined by reversed-phase thin-layer chromatography using RP-18 silica plates and methanol-aqueous Tris buffer solution mixtures as mobile phases. R M values of the compounds were linearly dependent on methanol concentration; extrapolation of these to 0% methanol gave the lipophilicity R M0 . log P TLC was obtained from R M0 by use of a calibration curve obtained for five standards of known experimental lipophilicity (log P). Lipophilicity log P calcd for the thirteen quinobenzothiazines was calculated by use of nine software products. The values determined were discussed in terms of structure-lipophilicity relationships. The results indicate that chromatographic lipophilicity R M0 can be used as a measure of the lipophilicity of the azaphenothiazine derivatives investigated.

Słowa kluczowe

EN

lipophilicity; azaphenothiazines; RP-TLC

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2009
• Tom: Vol. 21, no. 3
• Strony: 369--378
• Opis fizyczny: Bibliogr. 20 poz., rys., tab.

Twórcy

autor

Zięba A.

• The Medical University of Silesia Department of Organic Chemistry ul. Jagiellońska 4 41-200 Sosnowiec Poland

autor

Prus W.

• he University of Bielsko-Biała Institute of Environmental Protection and Engineering ul. Willowa 2 43-309 Bielsko-Biała Poland

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