Phenolic constituents, antimicrobial, antioxidant, and anticancer activities of ethyl acetate and n-butanol extracts of Senna italica

Khalaf, Omar M.; Ghareeb, Mosad A.; Saad, Amal M.; Madkour, Hassan M. F.; El-Ziaty, Ahmed K.; Abdel-Aziz, Mohamed S.

doi:10.1556/1326.2018.00412

Artykuł - szczegóły

Tytuł artykułu

Phenolic constituents, antimicrobial, antioxidant, and anticancer activities of ethyl acetate and n-butanol extracts of Senna italica

Autorzy

Khalaf Omar M. , Ghareeb Mosad A. , Saad Amal M. , Madkour Hassan M. F. , El-Ziaty Ahmed K. , Abdel-Aziz Mohamed S.

Wybrane pełne teksty z tego czasopisma

Identyfikatory

DOI

10.1556/1326.2018.00412

Warianty tytułu

Języki publikacji

Abstrakty

Different solvent extracts of the aerial parts of Senna italica (Mill.) were investigated for their chemical constituents and biological activities. Moreover, bio-guided fractionation led to isolation and identification of six compounds, namely: physcion (1), emodin (2), 2-methoxy-emodin-6-O-β-d-glucopyranoside (3), 1-hydroxy-2-acetyl-3-methyl-6-hydroxy-8-methoxynaphthalene (tinnevellin) (4), quercetin 3-O-α-l-rhamnopyranosyl-(1→6)-β-d-glucopyranoside (rutin) (5), and 1,6,8-trihydroxy-3-methoxy-9,10-dioxo-9,10-dihydroanthracene (6). The chemical structures of these compounds were established via 1D and 2D ¹H- and ¹³C-NMR spectroscopy. Ethyl acetate and n-butanol extracts as well as compound 3 were evaluated for their anticancer activity against tumor cell lines. The tested extracts showed a moderate to weak activity, while compound 3 showed a moderate activity against human liver cancer (Hep G2) and breast cancer (MCF-7) cell lines with IC₅₀ values of 57.5 and 42.3 μg/mL, respectively. Both ethyl acetate and n-butanol extracts exhibited antimicrobial activities with different strengths, i.e., ethyl acetate exhibited antimicrobial activity against seven test microbes while n-butanol extract showed antimicrobial activity against all tested microbes. This is the first report for the isolation of compound 3 as a new compound from S. italica growing in Egypt.

Słowa kluczowe

Senna italica antimicrobial anticancer ABTS anthraquinone

Wydawca

University of Silesia in Katowice
Akademiai Kiado

Czasopismo

Acta Chromatographica

Rocznik

2019

Tom

Vol. 31, no. 2

Strony

138--145

Opis fizyczny

Bibliogr. 50 poz., rys., tab.

Twórcy

autor

Khalaf Omar M.

Chemistry Department, Faculty of Science, Ain Shams University, El-Khalifa El-Mamoun, 11566 Abbassia, Cairo, Egypt

autor

Ghareeb Mosad A.

m.ghareeb@tbri.gov.eg

Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornaish El-Nile, 12411 Warrak El-Hadar, Imbaba (P.O. 30), Giza, Egypt

autor

Saad Amal M.

Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornaish El-Nile, 12411 Warrak El-Hadar, Imbaba (P.O. 30), Giza, Egypt

autor

Madkour Hassan M. F.

Chemistry Department, Faculty of Science, Ain Shams University, El-Khalifa El-Mamoun, 11566 Abbassia, Cairo, Egypt

autor

El-Ziaty Ahmed K.

Chemistry Department, Faculty of Science, Ain Shams University, El-Khalifa El-Mamoun, 11566 Abbassia, Cairo, Egypt

autor

Abdel-Aziz Mohamed S.

Microbial Chemistry Department, Genetic Engineering and Biotechnology Division, National Research Centre, El Behoos Street 33, Dokki-Giza 12622, Egypt

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Typ dokumentu

Bibliografia

Identyfikator YADDA

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