Study of Anticonvulsant Clobazam Drug by Sophisticated Instrumentation

• Autorzy: Bhogayta J. , Khatri T. , Ram V. , Dave P.
• Języki publikacji: EN

Abstrakty

EN

Clobazam (7-Chloro-1-methyl-5-phenyl-1,5-benzodiazepine-2,4(3H)-dione) an anticonvulsant drug used since 1984, with molecular formula C16H13ClN2O2 and molecular mass 300, was characterized with sophisticated instruments like FTIR, UV-NIR, GC-MS, TGA-DTA-DSC and Nano particle size analyzer with zeta potential. The compound was confirmed with the help of GC-MS and the mass of sample was found aggregate with the standard values and mass spectra compare with NIST and WELEY library data. The UV-NIR analysis showed that the λmax was 231 nm with methanol as a diluent. FTIR analysis of the Clobazam gave the characteristics peaks of cyclic amide. HPTLC was used to determine the purity of the drug. Thermal behavior was studied with TGA-DTA-DSC analysis. The particle size of clobazam was measured with the Nano particle size analyzer and Zeta potential of drud found -77.0 mV. The purity of drug check with Preparative HPLC system.

Słowa kluczowe

EN

clobazam; anticonvulsant drug; cyclic amide; benzodiazepine

• Wydawca: Przedsiębiorstwo Wydawnictw Naukowych "DARWIN"
• Czasopismo: International Letters of Chemistry, Physics and Astronomy
• Rocznik: 2014
• Tom: Vol. 10
• Strony: 1--13
• Opis fizyczny: Bibliogr. 10 poz., rys., wz.

Twórcy

autor

Bhogayta J.

• Department of Chemistry, KSKV Kachchh University, Mundra Road, Bhuj - 370 001, India

autor

Khatri T.

• Department of Chemistry, KSKV Kachchh University, Mundra Road, Bhuj - 370 001, India

autor

Ram V.

• Department of Chemistry, KSKV Kachchh University, Mundra Road, Bhuj - 370 001, India

autor

Dave P.

• Department of Chemistry, KSKV Kachchh University, Mundra Road, Bhuj - 370 001, India

Bibliografia

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• [8] Epilepsy New Zealand (2000). "Antiepileptic Medication". Archived from the original on 24 April 2005. Retrieved 11 July 2005.
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• [10] FDA Approves ONFI™ (clobazam) for the Adjunctive Treatment of Seizures Associated with Lennox-Gastaut Syndrome in Patients Two Years and Older. Retrieved 2011-10-25.