Liquid chromatographic enantioseparation, determination, bioassay and isolation of enantiomers of Ketorolac : a review

Bhushan, Ravi

doi:10.1556/1326.2021.00945

Artykuł - szczegóły

Tytuł artykułu

Liquid chromatographic enantioseparation, determination, bioassay and isolation of enantiomers of Ketorolac : a review

Autorzy

Bhushan Ravi

Wybrane pełne teksty z tego czasopisma

Identyfikatory

DOI

10.1556/1326.2021.00945

Warianty tytułu

Języki publikacji

Abstrakty

Ketorolac (Ket) is a potent non-narcotic analgesic drug (among the nonsteroidal anti-inflammatory drugs). The physiological activity of Ket resides with (S)-(-)-Ket while the drug is marketed and administered as a racemic mixture. Therefore, it is desirable that the pharmacokinetics is measured and quantified for enantiomers individually and not as a total drug. The present paper is focused on relevant literature on LC enantioseparation of (RS)-Ket along with bioassay, pharmacokinetic and clinical studiem within the discipline of analytical chemistry. HPLC and Thin layer chromatography (TLC) methods using both direct and indirect approaches are discussed. The methods provide chirality recognition even in the absence of pure enantiomers. Besides, a brief discussion on resolution by crystallization and enzymatic methods is included. The most interesting aspects include establishment of structure and molecular asymmetry of diastereomeric derivatives using LC-MS, proton nuclear magnetic resonance spectrometry, and by drawing conformations in three dimensional views by using certain software. A brief discussion has also been provided on the recovery of native enantiomers by TLC.

Słowa kluczowe

(RS)-Ketorolac enantioresolution bioassay liquid chromatography enzymatic method isolation of enantiomers

Wydawca

University of Silesia in Katowice
Akademiai Kiado

Czasopismo

Acta Chromatographica

Rocznik

2022

Tom

Vol. 34, no. 3

Strony

220--236

Opis fizyczny

Bibliogr. 75 poz., rys., wykr.

Twórcy

autor

Bhushan Ravi

rbushfcy54@gmail.com

Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, 247667, India

https://orcid.org/0000-0001-5098-9759

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Typ dokumentu

Bibliografia

Identyfikator YADDA

bwmeta1.element.baztech-85e7baa2-a03b-4801-993f-51efba1f1d48