Hydrogel coatings for artificial heart implants

• Autorzy: Trzaskowski M. , Butruk B. , Ciach T.
• Języki publikacji: EN

Abstrakty

EN

Polyurethanes (PU) are nowadays one of the most widely used types of polymers for biomedical applications. The segmented nature of these materials enables to obtain both flexibility and mechanical strength within the same material. However, there is a need to modify a surface of PU in order to produce highly hemocompatible materials that can be used in fabrication of permanent blood-contacting devices such as vascular implants, valves or hearts. Among many types of modifications, hydrogel coating appears to be very promising. Such modification increases the hydrophilicity of PU which in turn causes an increase in the bio- and hemocompatibility of the material. The aim of presented study was to create a polyvinylpyrrolidone (PVP) hydrogel coating onto a surface of polyurethane. A possibility of using a free radical polymerization reaction was investigated. The obtained materials were analyzed in terms of durability, swelling ratio and contact angle. The FTIR-ATR analysis confirmed that polyurethane surfaces have been successfully coated with PVP.

Słowa kluczowe

EN

polyurethane; polyvinylpyrrolidone; hydrogel coatings; artificial heart

• Wydawca: Foundation for Young Scientists
• Czasopismo: Challenges of Modern Technology
• Rocznik: 2011
• Tom: Vol. 2, no. 1
• Strony: 19--22
• Opis fizyczny: Bibliogr. 7 poz., wykr., rys.

Twórcy

autor

Trzaskowski M.

• Warsaw University of Technology, Faculty of Chemical Process and Engineering, Warynskiego 1, 00-645 Warsaw, Poland

autor

Butruk B.

autor

Ciach T.

Bibliografia

• [1] Aksoy, A.E., V. Hasirci, and N. Hasirci. “Surface modification of polyurethanes with covalent immobilization of heparin”. Macro molecular Symposia 269(1), 2008: 145–153.
• [2] Stryer, L. Biochemistry. 2003.
• [3] Pelis, K. “Blood clots: The nineteenthcentury debate over the substance and means of transfusion in Britain”. Annals of Science 54(4), 1997: 331–360.
• [4] Resiak, I., and G. Rokicki. “Modyfikowane poliuretany do zastosowań biomedycznych”. Polimery 45(9), 2000: 592–602 [In Polish].
• [5] Brzeska, J. „Nowe poliuretany do celów medycznych”. Forum Akademickie 4 (2009).
• [6] Jordan, S.W., and E.L. Chaikof. “Novel thromboresistant materials”. Journal of Vascular Surgery 45(6 SUPPL.), 2007: 104–115.
• [7] Sperling, K.S., U. Streller, and C. Werner. “Covalently immobilized thrombomodulin inhibits coagulation and complement activation of artificial surfaces in vitro”. Biomaterials 25 (2004): 5101–5113.